MIR1912

Summary

MIR1912 (microRNA 1912, HGNC:35396) is a microRNA gene on chromosome Xq23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302144 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35396
Approved symbol	MIR1912
Name	microRNA 1912
Location	Xq23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1912
Ensembl gene	ENSG00000222321
Ensembl biotype	miRNA
Entrez	100302144
RNAcentral	URS0000638502 — miRNA, 80 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000410389

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000410389 — 1 exons

Exon	Start	End
ENSE00001590207	114651544	114651623

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 80.56.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.56	gold quality
corpus callosum	UBERON:0002336	76.34	gold quality
heart	UBERON:0000948	73.83	gold quality
hypothalamus	UBERON:0001898	65.25	gold quality
caudate nucleus	UBERON:0001873	61.77	gold quality
Ammon’s horn	UBERON:0001954	61.63	gold quality
nucleus accumbens	UBERON:0001882	60.44	gold quality
lung	UBERON:0002048	59.21	gold quality
right testis	UBERON:0004534	38.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	Mir1912	ENSRNOG00000046748

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.