MIR1913

Summary

MIR1913 (microRNA 1913, HGNC:35397) is a microRNA gene on chromosome 6q27.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302141 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35397
Approved symbol	MIR1913
Name	microRNA 1913
Location	6q27
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1913
Ensembl gene	ENSG00000222958
Ensembl biotype	miRNA
Entrez	100302141
RNAcentral	URS000075C72C — miRNA, 80 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000411026

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000411026 — 1 exons

Exon	Start	End
ENSE00001590844	166509354	166509433

Expression profiles

Bgee: expression breadth broad, 69 present calls, max score 82.81.

Top tissues by expression

69 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	82.81	gold quality
calcaneal tendon	UBERON:0003701	82.25	gold quality
placenta	UBERON:0001987	75.36	gold quality
gastrocnemius	UBERON:0001388	73.32	gold quality
blood	UBERON:0000178	72.90	gold quality
stomach	UBERON:0000945	71.70	gold quality
heart	UBERON:0000948	71.28	gold quality
liver	UBERON:0002107	71.25	gold quality
right atrium auricular region	UBERON:0006631	70.04	gold quality
heart left ventricle	UBERON:0002084	69.93	gold quality
prefrontal cortex	UBERON:0000451	68.90	gold quality
endometrium	UBERON:0001295	68.72	gold quality
left coronary artery	UBERON:0001626	68.26	gold quality
left adrenal gland	UBERON:0001234	67.44	gold quality
transverse colon	UBERON:0001157	67.12	gold quality
tibial artery	UBERON:0007610	67.00	gold quality
body of stomach	UBERON:0001161	66.22	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.17	gold quality
skin of leg	UBERON:0001511	66.14	gold quality
right adrenal gland	UBERON:0001233	66.01	gold quality
zone of skin	UBERON:0000014	65.98	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.52	gold quality
fallopian tube	UBERON:0003889	65.50	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.41	gold quality
body of pancreas	UBERON:0001150	65.40	gold quality
lung	UBERON:0002048	65.33	gold quality
skin of abdomen	UBERON:0001416	65.24	gold quality
ectocervix	UBERON:0012249	65.24	gold quality
thoracic aorta	UBERON:0001515	65.21	gold quality
putamen	UBERON:0001874	65.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.