MIR1914

Summary

MIR1914 (microRNA 1914, HGNC:35398) is a microRNA gene on chromosome 20q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302137 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35398
Approved symbol	MIR1914
Name	microRNA 1914
Location	20q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1914
Ensembl gene	ENSG00000284433
Ensembl biotype	miRNA
Entrez	100302137
RNAcentral	URS000075A6FE — miRNA, 80 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000607800

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000607800 — 1 exons

Exon	Start	End
ENSE00003702137	63941465	63941544

Expression profiles

Bgee: expression breadth broad, 22 present calls, max score 92.51.

Top tissues by expression

22 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	92.51	gold quality
anterior cingulate cortex	UBERON:0009835	85.23	gold quality
stomach	UBERON:0000945	82.11	gold quality
skeletal muscle tissue	UBERON:0001134	81.22	gold quality
myometrium	UBERON:0001296	76.81	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	76.04	gold quality
colon	UBERON:0001155	74.89	gold quality
hypothalamus	UBERON:0001898	73.16	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.33	gold quality
muscle of leg	UBERON:0001383	69.77	gold quality
nucleus accumbens	UBERON:0001882	69.29	gold quality
leukocyte	CL:0000738	68.37	gold quality
prostate gland	UBERON:0002367	68.16	gold quality
Ammon’s horn	UBERON:0001954	67.85	gold quality
blood	UBERON:0000178	67.73	gold quality
right atrium auricular region	UBERON:0006631	66.15	gold quality
gastrocnemius	UBERON:0001388	63.88	gold quality
skin of leg	UBERON:0001511	61.68	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	58.16	gold quality
small intestine	UBERON:0002108	56.13	gold quality
caudate nucleus	UBERON:0001873	54.36	gold quality
subcutaneous adipose tissue	UBERON:0002190	53.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• miR-647 and miR-1914 promote the proliferation and migration equivalently by downregulating NFIX in CRC cells in vitro. (PMID:28990086)
• microRNA-1914, which is regulated by lncRNA DUXAP10, inhibits cell proliferation by targeting the GPR39-mediated PI3K/AKT/mTOR pathway in HCC. (PMID:31576658)
• The functional activity of the miR-1914-5p in lipid metabolism of the hepatocarcinoma cell line HepG2: a potential molecular tool for controlling hepatic cellular migration. (PMID:33907947)
• Monocyte-Derived miRNA-1914-5p Attenuates IL-1beta-Induced Monocyte Adhesion and Transmigration. (PMID:36769149)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.