MIR1915

Summary

MIR1915 (microRNA 1915, HGNC:35399) is a microRNA gene on chromosome 10p12.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302129 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35399
Approved symbol	MIR1915
Name	microRNA 1915
Location	10p12.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1915
Ensembl gene	ENSG00000222071
Ensembl biotype	miRNA
OMIM	615202
Entrez	100302129
RNAcentral	URS000075C681 — miRNA, 80 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000410139

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000410139 — 1 exons

Exon	Start	End
ENSE00001589957	21496562	21496641

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 75.70.

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	75.70	gold quality
right lobe of liver	UBERON:0001114	75.11	gold quality
fundus of stomach	UBERON:0001160	73.66	gold quality
heart left ventricle	UBERON:0002084	71.21	gold quality
blood	UBERON:0000178	69.90	gold quality
prefrontal cortex	UBERON:0000451	69.35	gold quality
ectocervix	UBERON:0012249	69.24	gold quality
substantia nigra	UBERON:0002038	69.10	gold quality
myometrium	UBERON:0001296	69.06	gold quality
left adrenal gland cortex	UBERON:0035825	68.97	gold quality
right lobe of thyroid gland	UBERON:0001119	68.59	gold quality
endometrium	UBERON:0001295	68.28	gold quality
stomach	UBERON:0000945	68.27	gold quality
adult mammalian kidney	UBERON:0000082	68.17	gold quality
right atrium auricular region	UBERON:0006631	68.04	gold quality
left adrenal gland	UBERON:0001234	67.97	gold quality
gastrocnemius	UBERON:0001388	67.38	gold quality
anterior cingulate cortex	UBERON:0009835	67.38	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.23	gold quality
amygdala	UBERON:0001876	67.22	gold quality
frontal cortex	UBERON:0001870	66.51	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.32	gold quality
transverse colon	UBERON:0001157	66.23	gold quality
Ammon’s horn	UBERON:0001954	66.17	gold quality
tibial nerve	UBERON:0001323	66.07	gold quality
body of stomach	UBERON:0001161	66.06	gold quality
right adrenal gland	UBERON:0001233	66.05	gold quality
left coronary artery	UBERON:0001626	65.99	gold quality
nucleus accumbens	UBERON:0001882	65.92	gold quality
left lobe of thyroid gland	UBERON:0001120	65.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.13

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• Short GC-rich RNA similar to miR 1909 and 1915 folds in silico with the 5’-UTR and ORF of Notch and responders. (PMID:21042738)
• Taken together, our findings suggest that miR-1915 could play a role in the development of MDR in colorectal carcinoma cells at least in part by modulation of apoptosis via targeting Bcl-2. (PMID:22121083)
• miR-1915 and miR-1225-5p regulated the expression of important markers of renal progenitors, such as CD133 and PAX2, and important genes involved in the repair mechanisms of adult renal progenitor cells, such as TLR2. (PMID:23861881)
• p53 negatively modulates Bcl-2 by controlling miR-1915. (PMID:24814047)
• miR19153p functions as a silencer of apoptosis, which regulates lung cancer apoptosis via targeting DRG2/PBX2. (PMID:26572100)
• Plasma miR-1914* and -1915 interact with NFIX RNA. (PMID:26695693)
• Study demonstrated that miR-1915-3p might promote the proliferation and metastasis of breast cancer by repression of DUSP3 and serum miR-1915-3p and miR-455-3p could serve as diagnostic and predictive biomarkers for breast cancer. (PMID:30048472)
• MiR-1915 exerted tumor-suppressive effects on cellular proliferation, invasion, and migration of helicobacter pylori-infected gastric cancer cells via targeting RAGE. (PMID:30554489)
• miR-1915-3p possibly contributes to the development and progression of gastric cancer by inhibiting the anti-apoptotic protein Bcl-2. The finding provides a potential therapeutic strategy for gastric cancer. (PMID:31036603)
• Serum Exosomal miRNA-1915-3p Is Correlated With Disease Activity of Korean Rheumatoid Arthritis. (PMID:32871836)
• Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p. (PMID:33009394)
• MicroRNA-1915-3p inhibits cell migration and invasion by targeting SET in non-small-cell lung cancer. (PMID:34774019)
• CircRNA-ABCB10 promotes gastric cancer progression by sponging miR-1915-3p to upregulate RaC1. (PMID:34987010)
• LncRNA TSPEAR-AS1 predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma and promotes metastasis via miR-1915-5p. (PMID:35477008)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.