MIR193A

Summary

MIR193A (microRNA 193a, HGNC:31563) is a microRNA gene on chromosome 17q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406968 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31563
Approved symbol	MIR193A
Name	microRNA 193a
Location	17q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-193, hsa-mir-193a
Ensembl gene	ENSG00000207614
Ensembl biotype	miRNA
OMIM	614733
Entrez	406968
RNAcentral	URS000075EC4B — miRNA, 88 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384882

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384882 — 1 exons

Exon	Start	End
ENSE00001499889	31559996	31560083

Expression profiles

Bgee: expression breadth broad, 85 present calls, max score 78.66.

Top tissues by expression

85 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	78.66	gold quality
right coronary artery	UBERON:0001625	77.18	gold quality
omental fat pad	UBERON:0010414	76.72	gold quality
leukocyte	CL:0000738	75.96	gold quality
adipose tissue	UBERON:0001013	74.97	gold quality
placenta	UBERON:0001987	74.62	gold quality
right lobe of liver	UBERON:0001114	74.42	gold quality
liver	UBERON:0002107	74.00	gold quality
gastrocnemius	UBERON:0001388	73.74	gold quality
left coronary artery	UBERON:0001626	73.73	gold quality
subcutaneous adipose tissue	UBERON:0002190	73.24	gold quality
thoracic mammary gland	UBERON:0005200	73.16	gold quality
heart	UBERON:0000948	71.96	gold quality
heart left ventricle	UBERON:0002084	71.38	gold quality
body of pancreas	UBERON:0001150	71.15	gold quality
adult mammalian kidney	UBERON:0000082	71.07	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.52	gold quality
right atrium auricular region	UBERON:0006631	70.51	gold quality
left uterine tube	UBERON:0001303	70.48	gold quality
blood	UBERON:0000178	70.33	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.31	gold quality
body of stomach	UBERON:0001161	70.12	gold quality
stomach	UBERON:0000945	70.05	gold quality
nucleus accumbens	UBERON:0001882	70.05	gold quality
endometrium	UBERON:0001295	70.04	gold quality
left adrenal gland cortex	UBERON:0035825	70.00	gold quality
left adrenal gland	UBERON:0001234	69.86	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.67	gold quality
lower esophagus	UBERON:0013473	69.65	gold quality
ascending aorta	UBERON:0001496	69.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.51

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): TP63, TP73

Literature-anchored findings (GeneRIF, showing 40)

• These data reveal a critical role for methylation-repressed miR-193a in myeloid leukemogenesis. (PMID:21399664)
• miR-193a inhibits cellular transformation by directly targeting the 3’ untranslated regions of PLAU & K-Ras. It controls anchorage-independent growth in soft agar through K-Ras, whereas it affects invasive growth through PLAU. (PMID:21670079)
• After epithelial-mesenchymal transition, miR-33a and mir-193a were downregulated in A549 cells. (PMID:22325218)
• Identification and validation of three miRNAs (miR-124, miR-147 and miR-193a-3p) as novel tumor suppressors that co-target EGFR-driven cell-cycle network proteins and inhibit cell-cycle progression and proliferation in breast cancer. (PMID:22333974)
• miR-193 plays a critical part in mesenchymal stem cell proliferation in response to low-level laser irradiation stimulation. (PMID:22384930)
• Our results therefore establish a novel miR-193a-5p-YY1-APC axis, which contributes to endometrioid endometrial carcinoma development (PMID:22907428)
• Data indicate that knockdown of interleukin enhancer-binding factor 3 (ILF3) leads to the increased levels of mature urokinase-type plasminogen activator (uPA) mRNA-targeting miRNAs miR-193a, miR-193b and miR-181a. (PMID:22986534)
• In human free tissue flaps, significant upregulation of miR-193-3p, miR-210, and miR-21 was detected at 72-hour reperfusion. (PMID:23097335)
• Our results indicated a feedback circuitry involving miR-193a and AML1/ETO/DNMTs/HDACs, cooperating with the PTEN/PI3K signaling pathway and contributing to leukemogenesis. (PMID:23223432)
• miR-193a-3p induces apoptosis in cancer cells by directly targeting Mcl-1. (PMID:23546867)
• miR-193a regulates proliferation and apoptosis in epithelial ovarian cancer cells (PMID:23588298)
• The triple miRNA classifier of miR-193a-3p, miR-23a and miR-338-5p appears to be a potential blood biomarker for early detection of colorectal cancer (PMID:23758639)
• miR193a-5p may have an important role in the inhibition of SMARCB1 mRNA expression. (PMID:24287458)
• Demethylation of miR-913a gene may produce proliferation-inhibiting and apoptosis-promoting effects due to repression of NF-kappaB and MCL1. (PMID:24356455)
• observed that miR-193a-3p/5p could inactivate the AKT/mTOR signaling pathway (PMID:24469061)
• MiR-193a-3p is direct targets to SRSF2, plasminogen activator and HIC2 genes in BCa cells. (PMID:25188512)
• Downregulation of miR-193a-5p correlates with lymph node metastasis and poor survival of colorectal carcinoma. (PMID:25232258)
• These results provide a set of the essential genes in this newly identified miR-193a-3p/LOXL4/Oxidative Stress axis. (PMID:25311867)
• Taken together, our findings provide the first clues regarding the role of miR-193a-3p as a tumor suppressor in lung cancer through the inhibition of ERBB4 translation. (PMID:25391651)
• PSEN1 acts as an important executor for the microRNA-193a-3p’s positive impact on the multi-chemoresistance of bladder cancer (PMID:25542424)
• Estrogen-mediated up-regulation of target of miR-193a, E2F6, can attenuate the function of miR-193a. (PMID:25545504)
• The results of the present study demonstrated that normalization of miRNA data, using a combination of hsa-miR-193a-5p and hsa-miR-16-5p as reference genes, may produce reliable and accurate results for the detection of serum miRNAs in bladder cancer (PMID:25738263)
• MiR-193a-3p inhibited the metastasis of lung cancer cells by deregulating the expression of tumor-related proteins. (PMID:25833338)
• miRNA-193a-3p can target colonic PepT1 and reduce intestinal inflammation. (PMID:25931122)
• HOTAIR modulated c-KIT expression by competitively binding miR-193a (PMID:25979172)
• High MIR 193a is associated with muscle-invasive bladder cancer. (PMID:25990459)
• Results showed that ING5 gene expression is inhibited by miR-193a-3p and is instrumental in miR-193a-3p’s role in activating BCa chemoresistance. (PMID:25991669)
• miR-193a-3p appears to have importance in the biology of malignant pleural mesothelioma and may represent a target for therapeutic intervention (PMID:26125439)
• our data demonstrate that miR-193b targets cyclin D1 in prostate cancer. (PMID:26129688)
• MIR193a-3p is upregulated in schizophrenia, but not in non-schizophrenia mental disorders. (PMID:26183697)
• MiR-193a-3p may be a tumor-suppressive miRNA which is down-regulated in hepatocellular carcinoma. (PMID:26263159)
• Downregulation of miR-193a-3p promoted loss of type II collagen by directly targeting MMP14 in IDD. miR-193a-3p inhibited IDD in vitro and in vivo. miR-193a-3p may be a promising candidate for prevention of degenerative disc disease. (PMID:26620678)
• Data indicate that serum microRNAs miR-141, miR-214, miR-146b-5p, and miR-193a-3p were decreased significantly in Parkinson’s disease (PD) patients compared with controls. (PMID:26631297)
• Conclude that UCA1 functions as an oncogene in non-small cell lung carcinoma, acting mechanistically by upregulating ERBB4 in part through ‘spongeing’ miR-193a-3p. (PMID:26655272)
• These findings suggest that miR-193a-3p contributes to the radiation and chemotherapy resistance of oesophageal carcinoma by down-regulating PSEN1. Thus, miR-193a-3p and PSEN1 might be potential biomarkers for chemoradiation resistant cancers. (PMID:26743123)
• MiR-193a-3p and miR-193a-5p play important roles in osteosarcoma metastasis through down-regulation of the Rab27B and SRR genes and therefore may serve as useful biomarkers for the diagnosis of osteosarcoma (PMID:26913720)
• MiR-193a-5p/ERBB2 have roles in response to chemoradiation therapy of esophageal squamous cell carcinoma (PMID:27203740)
• The authors found significant decreases in the expression levels of miR-193a-5p but no significant differences in those of miR-193a-3p in breast cancer. MiR-193a-3p suppressed breast cancer cell growth and migration and invasion abilities, whereas miR-193a-5p suppressed cell growth but did not influence cell motility. (PMID:27307030)
• Rescue experiments with mutated KRas 3’UTR showed very significantly that the anti-tumour effect of miR-193a-3p is via specific direct targeting of KRas and not due to other targets. (PMID:27669434)
• Results show that MiR-193a expression is decreased due to DNA hypermethylation in non-small cell lung cancers specimens. Restoration of miR-193a inhibits migration, invasion, and TGF-beta1-induced EMT through modulating WT1-E-cadherin axis. (PMID:27821145)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir193a-1	ENSDARG00000098319
danio_rerio	mir193a-2	ENSDARG00000105128
mus_musculus	Mir193a	ENSMUSG00000065395
drosophila_melanogaster	mir-193	FBGN0262330

Paralogs (1): MIR193B (ENSG00000207639)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.