MIR193B

Summary

MIR193B (microRNA 193b, HGNC:32087) is a microRNA gene on chromosome 16p13.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574455 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32087
Approved symbol	MIR193B
Name	microRNA 193b
Location	16p13.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-193b
Ensembl gene	ENSG00000207639
Ensembl biotype	miRNA
OMIM	614734
Entrez	574455
RNAcentral	URS000075BAEB — miRNA, 83 nt, 16 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384907

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384907 — 1 exons

Exon	Start	End
ENSE00001499914	14303967	14304049

Expression profiles

Bgee: expression breadth broad, 62 present calls, max score 82.82.

Top tissues by expression

62 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	82.82	gold quality
skeletal muscle tissue	UBERON:0001134	82.23	gold quality
placenta	UBERON:0001987	77.48	gold quality
fundus of stomach	UBERON:0001160	75.14	gold quality
monocyte	CL:0000576	74.64	gold quality
adrenal gland	UBERON:0002369	73.78	gold quality
muscle of leg	UBERON:0001383	72.82	gold quality
right atrium auricular region	UBERON:0006631	72.63	gold quality
blood	UBERON:0000178	72.51	gold quality
gastrocnemius	UBERON:0001388	72.24	gold quality
heart left ventricle	UBERON:0002084	71.89	gold quality
lung	UBERON:0002048	70.99	gold quality
heart	UBERON:0000948	70.27	gold quality
right hemisphere of cerebellum	UBERON:0014890	69.89	gold quality
endometrium	UBERON:0001295	69.53	gold quality
body of pancreas	UBERON:0001150	69.26	gold quality
tibial artery	UBERON:0007610	68.66	gold quality
ascending aorta	UBERON:0001496	68.16	gold quality
left coronary artery	UBERON:0001626	68.00	gold quality
left adrenal gland	UBERON:0001234	67.79	gold quality
body of stomach	UBERON:0001161	67.74	gold quality
left adrenal gland cortex	UBERON:0035825	67.74	gold quality
thoracic aorta	UBERON:0001515	67.51	gold quality
esophagus mucosa	UBERON:0002469	66.77	gold quality
transverse colon	UBERON:0001157	66.74	gold quality
putamen	UBERON:0001874	66.43	gold quality
minor salivary gland	UBERON:0001830	66.05	gold quality
descending thoracic aorta	UBERON:0002345	65.89	gold quality
omental fat pad	UBERON:0010414	65.63	gold quality
zone of skin	UBERON:0000014	65.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• miR-18a, miR-18b, miR-193b, miR-206 and miR-302c, were confirmed to directly target ERalpha in 3’-untranslated region reporter assays. (PMID:19684618)
• miR-193b is closely associated with clinical metastasis and identifies miR-193b potentially targets uPA transcripts. (PMID:19701247)
• Fndings suggest that miR-193b-365 cluster is part of the unique miRNA signature in MM. (PMID:19883314)
• data suggest that miR-193b is an epigenetically silenced putative tumor suppressor in prostate cancer (PMID:20073067)
• miR-193b represses cell proliferation and regulates CCND1 expression (PMID:20304954)
• the identification of multiple genes whose combinatorial knock-down likely mediates the strong anti-cancer effects observed for miR-193b in breast cancer cells (PMID:21512034)
• MicroRNA-193b regulates c-Kit proto-oncogene and represses cell proliferation in acute myeloid leukemia. (PMID:21724256)
• study found that miR-193b was down-regulated in non-small cell lung cancer (NSCLC), and that miR-193b inhibited NSCLC cancer cell proliferation and invasion in vitro; data suggest that miR-193b is a tumor suppressor in NSCLC (PMID:22491710)
• miR-199a-3p and miR-193b are involved in the senescence of chondrocytes, and miR-320c is involved in the juvenile properties of chondrocytes (PMID:22674437)
• Overexpression of miR-193b leads to increased resistance to carboplatin. (PMID:22752226)
• CFTR involved in the regulation of miR-193b in prostate cancer development. (PMID:22797075)
• Data indicate that knockdown of interleukin enhancer-binding factor 3 (ILF3) leads to the increased levels of mature urokinase-type plasminogen activator (uPA) mRNA-targeting miRNAs miR-193a, miR-193b and miR-181a. (PMID:22986534)
• Our findings identified miR-193b as a potentially novel prognostic marker in HNSCC that drives tumour progression via down-regulating NF1, in turn leading to activation of ERK. (PMID:23335975)
• miR-193b/365a cluster controls progression of epidermal squamous cell carcinoma. (PMID:24374827)
• This study indicates that miR-193b promotes cell proliferation by targeting Smad3 in human glioma. (PMID:24496888)
• miR-193bmay be a potential new biomarker of pancreatic neuroendocrine neoplasms (PMID:24778027)
• Modulation of miRNA 193b expression might be a potential way to enhance response to sorafenib in hepatitis b-associated hepatocellular carcinoma. (PMID:25034398)
• miR193b may function in the development of Alzheier disease and exosomal miR193b has potential as a novel, non-invasive, bloodbased biomarker of mild cognitive impairment. (PMID:25119742)
• miR-193b inhibits the expression of stathmin 1 (STMN1) and urokinase-type plasminogen activator (uPA) in Panc-1 cells. (PMID:25215905)
• MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia. (PMID:25231743)
• miR-193b down-regulation is associated with gastric cancer. (PMID:25374225)
• Downregulation of miR-193b in systemic sclerosis regulates the proliferative vasculopathy by urokinase-type plasminogen activator expression. (PMID:25384965)
• Treating naive Mos with a miR-193b induced expression of IL-10 in the Mos. (PMID:25517434)
• miR-192 and miR-193b abundance are increased in the prediabetic state and in glucose-intolerant mice. Circulating levels of miR-192 and miR-193b return to baseline in both prediabetic humans and glucose-intolerant mice undergoing chronic exercise. (PMID:25532038)
• miR-193b was significantly down-regulated in two primary human breast cancer cell lines (MDA-MB-231 and MCF-7). Reconstitution of miR-193b expression resulted in decreasing cell proliferation, clonogenicity, migration and invasion. (PMID:25550792)
• Data indicate that TGF-beta2 (TGFB2) and TGF beta type III receptor (TGFBR3) are target genes of miR-193b in chondrogenesis. (PMID:25728278)
• Downregulation of miR-193b drives ovarian cancer metastasis. (PMID:25798837)
• Over-expression of miR-193b suppressed the proliferation of K562 cells. (PMID:25854561)
• Findings show that miR-193b is frequently downregulated in pancreatic ductal adenocarcinoma samples and has potential tumor-suppressor activity. Dysregulation of the miR-193b-KRAS axis appears to be involved in pancreatic carcinogenesis. (PMID:25905463)
• Results indicated that miR-193b expression was downregulated in human liver cancer cells, that Mcl-1 was confirmed as its target, and the overexpression of miR-193b enhanced the sensitivity of cancer cells through the caspase-dependent apoptosis pathway. (PMID:25997995)
• In human adipocytes, miR-193b controls adiponectin production via pathways involving nuclear transcription factor Yalpha and possibly nuclear receptor interacting protein 1. (PMID:26020766)
• miR-193b sensitizes MCF-7/DOXR cells to doxorubicin through a mechanism involving the downregulation of MCL-1 (PMID:26526790)
• Results indicate that MIR31HG functions as an oncogenic long noncoding RNAs (lncRNAs) that promotes tumor progression, and miR-193b targets not only protein-coding genes but also the lncRNA, MIR31HG. (PMID:26549028)
• we detected and verified a list of differentially expressed microRNAs in PE placentas by HTS and qRT-PCR, and provided preliminary evidence for the role of miR-193b-3p in the pathogenesis of preeclampsia by targeting TGF-beta2. (PMID:26822621)
• Studied miRNAs in regulation of apoptosis & autophagy of oesophageal cancer; found MiR-193b was the most differentially expressed miRNA between chemosensitive/chemoresistant cell lines. (PMID:26878873)
• CND1 is a direct target of miR-193b in gastric cancer. (PMID:27071318)
• Downregulation of miR-193b and upregulation of K-Ras may contribute to the pathogenesis of esophageal cancer. (PMID:27176876)
• Patients with pancreatic ductal adenocarcinoma (PDAC) showed significantly higher amounts of serum MAPK-associated microRNAs miR-7, miR-34a, miR-181d and miR-193b than those with autoimmune pancreatitis (AIP). (PMID:27380024)
• miR-193b-3p might represent a useful biomarker to tailor and implement surveillance strategies for patients at high risk of developing CKD following radical nephrectomy (PMID:27802451)
• miR-505-5p and miR-193b-3p have the potential to serve as a biomarker for the assessment of imatinib therapy response in newly diagnosed CML patients. (PMID:28093001)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir193b	ENSDARG00000104984
mus_musculus	Mir193b	ENSMUSG00000076972
rattus_norvegicus	Mir193b	ENSRNOG00000046587
drosophila_melanogaster	mir-193	FBGN0262330

Paralogs (1): MIR193A (ENSG00000207614)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.