MIR197

Summary

MIR197 (microRNA 197, HGNC:31569) is a microRNA gene on chromosome 1p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406974 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31569
Approved symbol	MIR197
Name	microRNA 197
Location	1p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-197
Ensembl gene	ENSG00000284443
Ensembl biotype	miRNA
OMIM	611189
Entrez	406974
RNAcentral	URS00000F4AC3 — miRNA, 75 nt, 45 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384976

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384976 — 1 exons

Exon	Start	End
ENSE00001499983	109598893	109598967

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Studies indicate that miR-21 was upregulated and mir-197 was downregulated in glioblastoma. (PMID:21435175)
• Study shows that the expression of miR-222, miR-328, miR-197, and miR-21 combined in a predictive model is accurate at differentiating malignant from benign indeterminate thyroid lesions on fine needle aspiration (FNA). (PMID:22351693)
• Identify miR-197 as an up-regulated miRNA specifically in invasive ductal adenocarcinoma. (PMID:23139153)
• Results indicate that miR-9 and MiR-197 specifically downregulate MTHFD1L in HEK293 and MCF-7 cells and that SNPrs7646 affects miR-197 binding to the MTHFD1L 3’ UTR causing gene repression in the presence of the allele associated with neural tube defects. (PMID:24123340)
• Taken together, these data suggest that anti-miR-197 suppresses HCC migration and invasion by targeting CD82. (PMID:24613834)
• This study supports a role of miR-197 as an anti-oncogene and a biomarker for EC and its relationship with other prognostic factors and survival. (PMID:25117314)
• IL-22 activates miR-197 expression through the binding of phosphorylated STAT3 to sequences in the putative promoter of miR-197. (PMID:25208211)
• Our analysis showed significant downregulation of miRNAs, let-7b and miR-197, out of which miR-197 was predicted to target FOXJ2. (PMID:25451482)
• miR-137/197 act as tumor suppressors in mediating apoptosis in multiple myeloma cells by targeting MCL-1. (PMID:25724519)
• our work first demonstrated that miR-197 can confer drug resistance to Taxol, by regulating tumor suppressor, NLK expression in ovarian cancer cells. (PMID:25833695)
• High expression of miR-197 is associated with larger tumours and the squamous cell carcinoma histotype in non-small cell lung cancer. (PMID:25867273)
• miR-197 could play an anti-oncogenic role in human uterus leiomyoma cells. (PMID:25960207)
• upregulation inhibits cell proliferation of uterine leiomyoma by directly targeting IGFBP5 (PMID:25990270)
• miR-197 mediates the response of colorectal cancer cells to 5-FU by regulating thymidylate synthase expression. (PMID:26055341)
• All the results demonstrated that FUS1 acts as a tumor-suppressor gene by upregulating miR-197 in human glioblastoma and implied that restoration of FUS1 and miR-197 could be new therapeutic strategies for glioblastoma. (PMID:26081814)
• MicroRNA197 reverses the drug resistance of fluorouracilinduced SGC7901 cells by targeting MAPK1. (PMID:26151540)
• miRNA-197 and miRNA-184 are overexpressed in EGFR-mutant lung adenocarcinoma patients with brain metastases and they might be a new biomarker for stratifying the risk of BM in this subpopulation. (PMID:26199015)
• Suggested that miR-197 could play an important role in the development and progression of uterine leiomyoma through the JAK/STAT signal pathway, Toll-like receptor signaling athway and other pathways. (PMID:26311392)
• mir-106a, mir-122 and mir-197 could be potential markers for severe acute viral hepatitis associated with coagulopathy. (PMID:26352910)
• Enterovirus 71-induced downregulation of miR-197 expression increased the expression of RAN, which supported the nuclear transport of the essential viral proteins 3D/3CD and host protein hnRNP K for viral replication. (PMID:26581983)
• Serum-derived circulating miRNA-197 and miRNA-223 were identified as predictors for cardiovascular death in a large patient cohort with CAD. (PMID:26720041)
• overexpression of GAB2 suppressed the expression of miR197 in glioblastoma cells. (PMID:27035789)
• results indicated that miR-197 targeted IGFBP3 to induce the overgrowth and anti-apoptotic effects of Wilms tumor cells (PMID:27223680)
• the functions of miR-197 in initiation and progression of various cancers (review) (PMID:27320730)
• The migration test revealed that the downregulation of miR-197-3p and overexpression of LINC00312 inhibited bladder cancer cell migration and invasion abilities, while the overexpression of miR-197-3p and the upregulation of LINC00312 promoted cell migration and invasion. (PMID:27631965)
• Three circulating up-regulated microRNAs, miR-197-3p, miR-1281 and miR-32-3p, are proposed as potential new malignant pleural mesothelioma biomarkers. (PMID:27716620)
• miR-197 and EpsteinBarr virus -BART-6-3p inhibit the expression of IL-6R in EpsteinBarr virus -positive Burkitt lymphoma cells. (PMID:28259992)
• Low miR197 expression is associated with Colorectal Cancer. (PMID:29137688)
• miR-197-3p-induced downregulation of CYLD promotes cell proliferation and inhibits cell apoptosis in lung adenocarcinoma cell lines. (PMID:29286108)
• The downregulation of miR-197 suppresses the EMT and migration ability. HIPK2 is a direct functional target of miR-197 in LAD metastasis. In summary, miR-197 controls EMT and metastasis by directly silencing HIPK2. (PMID:29666324)
• These results suggest the role of miR-197 as a biomarker with potential therapeutic implications. (PMID:29890998)
• study illustrated a novel signaling cascade of LINC00641/miR-197-3p/KLF10/PTEN/PI3K/AKT pathway regulating bladder cancer development (PMID:30060954)
• nemo-like kinase (NLK), which was positively controlled by TUG1, was a target gene of miR-197. (PMID:30098551)
• In cancerous tissues of colorectal cancer (CRC) patients, the miR197 level was inversely correlated with the expression of IGFBP3, which indicated that miR197 may modulate cell migration and invasion by targeting IGFBP3 in CRC patients. (PMID:30106114)
• seven of eight selected genes potentially related to viral replication and immune response were validated as direct miR197 targets (PMID:30336044)
• finding supports that DLX6-AS1 accelerates the glioma carcinogenesis by competing endogenous sponging miR-197-5p to relieve E2F1, acting as a novel therapeutic target for glioma. (PMID:30366080)
• The important function of SNHG20/miR-197/LIN28 axis in the oncogenesis. (PMID:30394668)
• MiR-197 directly targeted Axin-2, Naked cuticle 1 (NKD1), and Dickkopf-related protein 2 (DKK2), leading to inhibition of Wnt/beta-catenin signaling. The overexpression of miR-197 promotes metastasis in hepatocellular carcinoma by suppressing the beta-catenin signaling pathway. (PMID:30453289)
• Low miR-197 expression is associated with glioblastoma. (PMID:30548670)
• miR-197-5P is a circulation miRNA that correlates with myocardial fibrosis and adverse cardiac events in heart failure patients under the age of 50 years. (PMID:30836355)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.