MIR1972-1

Summary

MIR1972-1 (microRNA 1972-1, HGNC:37060) is a microRNA gene on chromosome 16p13.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302243 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37060
Approved symbol	MIR1972-1
Name	microRNA 1972-1
Location	16p13.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1972
Ensembl gene	ENSG00000238728
Ensembl biotype	miRNA
Entrez	100302243
RNAcentral	URS000075BB4D — miRNA, 77 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000459337

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000459337 — 1 exons

Exon	Start	End
ENSE00001808707	15010321	15010397

Expression profiles

Bgee: expression breadth broad, 82 present calls, max score 97.17.

Top tissues by expression

82 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.17	gold quality
calcaneal tendon	UBERON:0003701	70.45	gold quality
blood	UBERON:0000178	70.25	gold quality
adrenal tissue	UBERON:0018303	69.81	gold quality
fundus of stomach	UBERON:0001160	69.30	gold quality
muscle of leg	UBERON:0001383	66.30	gold quality
endometrium	UBERON:0001295	66.07	gold quality
body of pancreas	UBERON:0001150	65.34	gold quality
islet of Langerhans	UBERON:0000006	65.27	gold quality
stomach	UBERON:0000945	64.54	gold quality
gastrocnemius	UBERON:0001388	64.44	gold quality
mucosa of transverse colon	UBERON:0004991	64.33	gold quality
skeletal muscle tissue	UBERON:0001134	63.99	gold quality
amygdala	UBERON:0001876	63.90	gold quality
liver	UBERON:0002107	63.38	gold quality
heart left ventricle	UBERON:0002084	62.95	gold quality
adrenal gland	UBERON:0002369	62.57	gold quality
adult mammalian kidney	UBERON:0000082	62.16	gold quality
body of stomach	UBERON:0001161	61.84	gold quality
Ammon’s horn	UBERON:0001954	61.77	gold quality
heart	UBERON:0000948	61.41	gold quality
apex of heart	UBERON:0002098	61.27	gold quality
minor salivary gland	UBERON:0001830	60.78	gold quality
right lobe of liver	UBERON:0001114	60.59	gold quality
right adrenal gland	UBERON:0001233	60.51	gold quality
muscle layer of sigmoid colon	UBERON:0035805	60.17	gold quality
gall bladder	UBERON:0002110	60.11	gold quality
left adrenal gland	UBERON:0001234	59.70	gold quality
intestine	UBERON:0000160	59.68	gold quality
nucleus accumbens	UBERON:0001882	59.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.25

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• This study demonstrated that MIR1972-1 in patient with major depression disorder was up regulation in peripheral blood mononuclear cells. (PMID:25201637)
• Circulating microRNAs as Potential Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma. (PMID:31320713)
• mRNA and miRNA Profiles of Exosomes from Cultured Tumor Cells Reveal Biomarkers Specific for HPV16-Positive and HPV16-Negative Head and Neck Cancer. (PMID:33202950)
• Integrated analysis of microRNA and mRNA expression profiling identifies BAIAP3 as a novel target of dysregulated hsa-miR-1972 in age-related white matter lesions. (PMID:33561007)
• RA Fibroblast-Like Synoviocytes Derived Extracellular Vesicles Promote Angiogenesis by miRNA-1972 Targeting p53/mTOR Signaling in Vascular Endotheliocyte. (PMID:35350778)

Cross-species orthologs

0 orthologs

Paralogs (1): MIR1972-2 (ENSG00000239118)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.