MIR1976

Summary

MIR1976 (microRNA 1976, HGNC:37064) is a microRNA gene on chromosome 1p36.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302190 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37064
Approved symbol	MIR1976
Name	microRNA 1976
Location	1p36.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1976
Ensembl gene	ENSG00000238705
Ensembl biotype	miRNA
Entrez	100302190
RNAcentral	URS000075E8FF — miRNA, 52 nt, 7 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000459548

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000459548 — 1 exons

Exon	Start	End
ENSE00001808351	26554542	26554593

Expression profiles

Bgee: expression breadth broad, 52 present calls, max score 83.75.

Top tissues by expression

52 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	83.75	gold quality
anterior cingulate cortex	UBERON:0009835	81.44	gold quality
gastrocnemius	UBERON:0001388	75.86	gold quality
monocyte	CL:0000576	74.46	gold quality
hypothalamus	UBERON:0001898	71.70	gold quality
body of stomach	UBERON:0001161	71.42	gold quality
heart left ventricle	UBERON:0002084	71.39	gold quality
substantia nigra	UBERON:0002038	70.30	gold quality
tibial artery	UBERON:0007610	70.06	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.71	gold quality
body of pancreas	UBERON:0001150	69.63	gold quality
Ammon’s horn	UBERON:0001954	69.42	gold quality
left coronary artery	UBERON:0001626	69.39	gold quality
amygdala	UBERON:0001876	69.32	gold quality
upper lobe of left lung	UBERON:0008952	69.29	gold quality
right lobe of liver	UBERON:0001114	69.16	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.86	gold quality
left adrenal gland	UBERON:0001234	68.66	gold quality
nucleus accumbens	UBERON:0001882	68.41	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.40	gold quality
skin of abdomen	UBERON:0001416	68.38	gold quality
adenohypophysis	UBERON:0002196	68.17	gold quality
skin of leg	UBERON:0001511	67.89	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.57	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.45	gold quality
esophagus mucosa	UBERON:0002469	67.28	gold quality
transverse colon	UBERON:0001157	67.24	gold quality
brain	UBERON:0000955	66.85	gold quality
vagina	UBERON:0000996	66.84	gold quality
ascending aorta	UBERON:0001496	66.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Taken together, our data highlight the pivotal role of miR-1976 in the progression of NSCLC. Thus, miR-1976 may be a potential prognostic marker and of treatment relevance for NSCLC progression intervention. (PMID:27063799)
• The bioinformatic prediction revealed that TP53 was a putative target gene of miR-612 and CD40 of miR-1976. Moreover, TP53 was downregulated in the expression array when comparing HR vs LR expression levels adjusted by sex, diet, age and baseline weight, and CD40 showed a statistical trend. (PMID:30089130)
• MiR-1976 plays an important role in the SAN aging process by targeting Cav1.2 and Cav1.3. (PMID:31302118)
• The low expression of miR-1976 in plasma samples indicating its biological functions in the progression of breast cancer. (PMID:32419112)
• MiR-1976 knockdown promotes epithelial-mesenchymal transition and cancer stem cell properties inducing triple-negative breast cancer metastasis. (PMID:32620748)
• MiR-1976/NCAPH/P65 axis inhibits the malignant phenotypes of lung adenocarcinoma. (PMID:38755247)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.