MIR198

Summary

MIR198 (microRNA 198, HGNC:31570) is a microRNA gene on chromosome 3q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406975 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31570
Approved symbol	MIR198
Name	microRNA 198
Location	3q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-198
Ensembl gene	ENSG00000284121
Ensembl biotype	miRNA
Entrez	406975
RNAcentral	URS0000471A62 — miRNA, 62 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637333

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637333 — 1 exons

Exon	Start	End
ENSE00003797258	120395668	120395729

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 78.66.

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	78.66	gold quality
caudate nucleus	UBERON:0001873	74.52	gold quality
blood	UBERON:0000178	66.78	gold quality
right frontal lobe	UBERON:0002810	65.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• These results suggest that the three miRNAs are negative regulators of Fus1 expression in lung cancers. (PMID:19671678)
• Data show that miR-198 targets c-MET via its 3’UTR, and that forced expression of miR-198 decreased c-MET expression and diminished HGF-induced phosphorylation of p44/42 MAPK. (PMID:21658389)
• Intra-renal expression of miR-638, miR-198 and miR-146a are differentially expressed between lupus nephritis patients and normal controls. (PMID:22295894)
• Livin expression may be regulated by miR-198 in human prostate cancer cell lines. (PMID:23069480)
• study shows that expression of miR-198 was significantly downregulated in lung adenocarcinoma-associated malignant pleural effusion compared with benign pleural effusion (PMID:23354517)
• In conclusion, miR-198 acts as a tumor suppressor by repression of mitogenic and motogenic pathways diminishing cell growth and migration. (PMID:23391410)
• A clear inverse correlation between the expression pattern of FSTL1 (pro-migratory) and miR-198 (anti-migratory) highlights the importance of this regulatory switch in controlling context-specific gene expression to orchestrate wound re-epithelialization. (PMID:23395958)
• miR-198 acts as a central tumor suppressor and modulates the molecular makeup of a critical interactome in pancreatic cancer. (PMID:23989979)
• MiR-198 was shown to target the 3’UTR of FUT8 directly to downregulate FUT8 expression. (PMID:25174450)
• MiR-21, miR-34a, miR-198 and miR-217 are diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma (PMID:25908274)
• miR-198 inhibited HaCaT cell proliferation by directly targeting CCND2. (PMID:26225959)
• Decreased miR-198 expression is associated with gastric cancer. (PMID:26852230)
• These findings suggested that miR-198 may act not only as a novel prognostic marker, but also as a potential target for molecular therapy of osteosarcoma. (PMID:26970302)
• JAK3 and MCL-1 were down-regulated in patient CD8(+) T cells versus their normal counterparts, likely due to defective suppressor activity of miR-29b and miR-198 in RCC CD8(+) T cells. (PMID:27063186)
• miR-198 decreased the protein expression of MGMT through inhibiting the translation of the MGMT mRNA into the MGMT protein in vitro and in vivo. Results showed that MiR-198 induces temozolomide chemosensitivity in glioblastoma by targeting MGMT and that miR-198 may be used as a new diagnostic marker and therapeutic target for glioblastoma in the future. (PMID:28425046)
• The overexpression of Livin is partly caused by the downregulation of miR-198. Further exploration revealed that miRNA-198-mediated silencing of Livin significantly inhibited cell growth and enhanced apoptosis of A549 cells. (PMID:28765921)
• miR-198 may promote proliferation and contribute to systemic lupus erythematosus progression by targeting PTEN. (PMID:28944868)
• Loss of miR198 expression is associated with liver metastasis in colorectal cancer stroma. (PMID:29065427)
• High miR 198 expression is associated with lung squamous cell carcinoma. (PMID:29394946)
• miR-198 could induce apoptosis and inhibit the proliferation, migration, and invasion of gastric cancer cells through downregulating Toll-like receptor 4 expression (PMID:29762851)
• circ_0025039 promotes cell growth, invasion and glucose metabolism in malignant melanoma by sponging miR-198 and regulating CDK4. (PMID:30219673)
• Overexpression of miR-198 inhibits CRC cell proliferation and colony formation but promotes apoptosis and ADAM metallopeptidase domain 28 (ADAM28) was a direct target of miR-198, and the overexpression of ADAM28 reversed the effects of miR-198 on cell behaviors. (PMID:30840270)
• Results show that miR-198 expression is regulated by circAKT sponging to upregulate its target PIK3R1, thus enhancing cisplatin resistance in gastric cancer. (PMID:30927924)
• miR-198 and miR-1183 were the two most significantly up-regulated microRNAs, and, miR-30e-5p and miR-144-3p were the two most significantly down-regulated microRNAs in Uyghur population with essential hypertension. (PMID:30975221)
• FGFR1 overexpression antagonized the anti-tumor effects of miR-198 overexpression. MiR-198/FGFR1 axis plays an important role in proliferation and apoptosis of gastric cancer (GC) (PMID:31138759)
• LINC00473 may function as an endogenous completive RNA by sponging miR-198 to regulate MAPK1 expression (PMID:31201066)
• Low miR198 expression is associated with prostate cancer progression. (PMID:31322262)
• MicroRNA-198-5p inhibits the migration and invasion of non-small lung cancer cells by targeting fucosyltransferase 8. (PMID:31381176)
• Circ0004390 promotes cell proliferation through sponging miR-198 in ovarian cancer. (PMID:32192774)
• Circular RNA LPAR3 sponges microRNA-198 to facilitate esophageal cancer migration, invasion, and metastasis. (PMID:32495982)
• MicroRNA-198 inhibits metastasis of thyroid cancer by targeting H3F3A. (PMID:33336742)
• circ_0002060 Enhances Doxorubicin Resistance in Osteosarcoma by Regulating the miR-198/ABCB1 Axis. (PMID:33351694)
• MicroRNA198 suppresses tumour growth and metastasis in oral squamous cell carcinoma by targeting CDK4. (PMID:33982769)
• MiR-198 inhibits proliferation, invasion and migration of ovarian cancer cells by regulating the PI3K/Akt signaling pathway. (PMID:34181826)
• Circular RNA circSP3 promotes hepatocellular carcinoma growth by sponging microRNA-198 and upregulating cyclin-dependent kinase 4. (PMID:34314379)
• Circular RNA circ_0089153 acts as a competing endogenous RNA to regulate colorectal cancer development by the miR-198/SUMO-specific peptidase 1 (SENP1) axis. (PMID:34516314)
• Hsa_circ_0074032 promotes prostate cancer progression through elevating homeobox A1 expression by serving as a microRNA-198 decoy. (PMID:34799875)
• Emerging role and function of miR-198 in human health and diseases. (PMID:34952425)
• SQSTM1/p62 promotes miR-198 loading into extracellular vesicles and its autophagy-related secretion. (PMID:36050615)
• Knockdown of circMFN2 inhibits cell progression and glycolysis by miR-198/CUL4B pathway in ovarian cancer. (PMID:37158446)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.