MIR199A1

Summary

MIR199A1 (microRNA 199a-1, HGNC:31571) is a microRNA gene on chromosome 19p13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406976 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31571
Approved symbol	MIR199A1
Name	microRNA 199a-1
Location	19p13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-199a-1
Ensembl gene	ENSG00000207752
Ensembl biotype	miRNA
OMIM	610719
Entrez	406976
RNAcentral	URS0000759977 — miRNA, 71 nt, 10 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385019

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385019 — 1 exons

Exon	Start	End
ENSE00001500026	10817426	10817496

Expression profiles

Bgee: expression breadth broad, 90 present calls, max score 81.42.

Top tissues by expression

90 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	81.42	gold quality
bone marrow	UBERON:0002371	80.98	gold quality
blood	UBERON:0000178	80.01	gold quality
adrenal tissue	UBERON:0018303	77.66	gold quality
fundus of stomach	UBERON:0001160	75.63	gold quality
monocyte	CL:0000576	75.20	gold quality
endometrium	UBERON:0001295	74.99	gold quality
muscle of leg	UBERON:0001383	74.02	gold quality
gastrocnemius	UBERON:0001388	73.49	gold quality
stomach	UBERON:0000945	72.64	gold quality
granulocyte	CL:0000094	71.95	gold quality
descending thoracic aorta	UBERON:0002345	71.57	gold quality
skin of abdomen	UBERON:0001416	71.52	gold quality
skin of leg	UBERON:0001511	71.42	gold quality
body of stomach	UBERON:0001161	71.37	gold quality
prefrontal cortex	UBERON:0000451	71.06	gold quality
smooth muscle tissue	UBERON:0001135	71.04	gold quality
body of pancreas	UBERON:0001150	70.30	gold quality
liver	UBERON:0002107	70.30	gold quality
left adrenal gland cortex	UBERON:0035825	69.92	gold quality
substantia nigra	UBERON:0002038	69.83	gold quality
right lung	UBERON:0002167	69.78	gold quality
transverse colon	UBERON:0001157	69.32	gold quality
heart left ventricle	UBERON:0002084	69.00	gold quality
heart	UBERON:0000948	68.93	gold quality
right ovary	UBERON:0002118	68.84	gold quality
colon	UBERON:0001155	68.80	gold quality
endocervix	UBERON:0000458	68.78	gold quality
amygdala	UBERON:0001876	68.74	gold quality
right atrium auricular region	UBERON:0006631	68.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Identification of the microRNA hsa-miR-199a as a regulator of IKKbeta expression. (PMID:18408758)
• the MET proto-oncogene and the downstream extracellular signal-regulated kinase 2 (ERK2) are regulated by MicroRNA miR-199a* (PMID:18456660)
• An inverse correlation between the expression of miR-199a-3p and CD44 protein was noted in primary hepatocellular carcinoma specimens. (PMID:21055388)
• results reveal that miR-199a and Brm form a double-negative feedback loop through Egr1, leading to the generation of two distinct cell types during carcinogenesis. (PMID:21189327)
• This report identifies DNA methylation, miR-199a dysregulation and PODXL as critical factors in tumor malignancy. (PMID:21383689)
• Results suggests that miR-199a-3p may play a functional role in osteosarcoma cell growth and proliferation). (PMID:21666078)
• demonstrate low miR-199a expression as a feature of advanced RCCs, identify miR-199a as a negative regulator of GSK-3beta (PMID:22093618)
• In hepatocytes, farnesoid X receptor represses production of miR-199a-3p (PMID:22265968)
• LIF expression might be regulated by microRNA-199a (PMID:22285730)
• miR-199a* is a direct regulator of COX-2 expression in osteoarthritis chondrocytes. (PMID:22294637)
• MicroRNA-199a-5p is associated with hypoxia-inducible factor-1alpha expression in lungs from patients with COPD. (PMID:22383663)
• miR-199a-3p and miR-193b are involved in the senescence of chondrocytes, and miR-320c is involved in the juvenile properties of chondrocytes (PMID:22674437)
• miR-199a-5p can regulate CAC1 and function as a tumor suppressor in colorectal cancer. (PMID:22903020)
• The varied and protean functions of miR-199a. [Review] (PMID:22942713)
• High expression of miRNA-199a-3p in plasma was associated with tumor invasion and with metastasis in gastric cancer. (PMID:22956063)
• These findings identify miR-199a-3p/miR-214 as important regulators of myometrial contractility and provide new insight into strategies to prevent preterm birth. (PMID:22973051)
• microRNA miR-199a-5p down-regulation switches on wound angiogenesis by derepressing the v-ets erythroblastosis virus E26 oncogene homolog 1-matrix metalloproteinase-1 pathway (PMID:23060436)
• miR-30d, miR-181a, & miR-199a-5p are down-regulated in several cancers & tumor cell lines. They act cooperatively to down-regulate GRP78 and induce apoptosis by directly targeting its 3’ untranslated region. (PMID:23085757)
• The circulating miRNAs miR-199a, miR-122, miR-145*, and miR-542-3p could potentially serve as noninvasive biomarkers for endometriosis. (PMID:23118427)
• A decreased expression of miR-199a is significantly correlated with a higher tumor stage, a greater likeliness of tumor recurrence, and a poorer prognosis in renal cell carcinoma. (PMID:23174576)
• the microRNA miR-199a-5p is identified as an important regulator of intercellular junctions. (PMID:23201090)
• Findings demonstrated that the three-miRNA signature of miR-21, miR-199a-3p, and miR-143, could discriminate cases of osteosarcoma from controls (PMID:23269581)
• These results suggested that miR-199a-3p may serve as an efficient biomarker for diagnosis and novel prognostic indicator in colorectal cancer. (PMID:23292866)
• MIR199A, which is frequently downregulated in hepatocellular carcinoma, is upregulated by the antineoplastic action of propofol. (PMID:23319430)
• miR-199a-5p as a novel and unique regulator of autophagy, which plays an important role in cancer biology and cancer therapy. (PMID:23337876)
• The TWIST1/miR-199/214 axis is down-regulated in dilated cardiomyopathy with increased activity of ubiquitin proteasome system. (PMID:23360823)
• This study provides a rationale for new therapeutic approach to suppress tumor angiogenesis using miR-199a, miR-125b, or their mimics for ovarian cancer treatment in the future. (PMID:23437196)
• The mir-199a-5p directly targets GRP78, ATF6, and IREalpha 3’UTR in hepatocytes (PMID:23598416)
• HGF is distinctly regulated at the posttranscriptional level from its antagonist isoform, NK2, via microRNA-199. (PMID:23657814)
• Expression of miRNA-199a-3p in plasma in early gastric cancer was higher than in healthy controls and gastric precancerous disease patients. miRNA-199a-3p level in post-operative plasma was reduced compared to pre-operative plasma. (PMID:23733518)
• Human cytomegalovirus infection of endothelial cells upregulates miR-199a-5p expression and enhances cell migration and tube formation through downregulation of SIRT1/eNOS by miR-199a-5p. (PMID:23760629)
• Manipulation of miR-199a-5p expression in human primary myoblasts and myotubes resulted in dramatic changes in cellular size, proliferation, and differentiation. (PMID:23764775)
• Downregulation of MicroRNA-199a-3p is associated with endometrial cancer. (PMID:23851675)
• Deregulation of miR-199a-3p expression provides novel mechanistic insights into TGCT carcinogenesis. (PMID:23959088)
• downregulation of miR-199a is essential for hypoxia-induced proliferation through derepressing the expression of HIF1a expression and affecting HIF1a mediated glycolytic pathway in non-small cell lung cancer progression. (PMID:24022342)
• our findings suggest that miRNA-199a-3p is associated with human gastric cancer through its ability to decrease cancer cell proliferation and target the mTOR signaling pathway (PMID:24065659)
• miR-199a-5p is a key regulator of the unfolded protein response in alpha1-antitrypsin-deficient monocytes, and epigenetic silencing of its expression regulates this process in chronic obstructive pulmonary disease. (PMID:24299514)
• Loss of microRNA-199a is associated with testicular germ cell tumor and glioblastomas. (PMID:24391856)
• findings indicated that miR-199a-3p target HGF/c-Met signaling pathway which is crucial for renal cell carcinoma (RCC) development and suggest that miR-199a-3p may serve as a potential target miRNA for RCC therapy (PMID:24609899)
• miR-199a-3p agomir inhibits aurora kinase A and attenuates xenograft tumor growth of prostate cancer. (PMID:24631181)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir199-2a	ENSDARG00000081869
mus_musculus	Mir199a-1	ENSMUSG00000065547

Paralogs (2): MIR199B (ENSG00000207581), MIR199A2 (ENSG00000208024)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.