MIR19B1

Summary

MIR19B1 (microRNA 19b-1, HGNC:31575) is a microRNA gene on chromosome 13q31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406980 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31575
Approved symbol	MIR19B1
Name	microRNA 19b-1
Location	13q31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-19b-1
Ensembl gene	ENSG00000284375
Ensembl biotype	miRNA
OMIM	609419
Entrez	406980
RNAcentral	URS00003BACA4 — miRNA, 87 nt, 41 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384829

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384829 — 1 exons

Exon	Start	End
ENSE00001499836	91351192	91351278

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 58.30.

Top tissues by expression

1 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
spleen	UBERON:0002106	58.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• a circuit involving c-myc, miR-17-92, and HIF-1 alpha may play a role in cancer cell proliferation under normoxia in a cellular context-dependent manner [miR-92] (PMID:18632605)
• Expression of miR-17-19b is inhibited in K562 cell line after 5-aza treatment. (PMID:21176349)
• miR-19b-1 controls the intrinsic angiogenic activity of human umbilical vein endothelial cells in vitro. (PMID:22197821)
• microRNA-17 and -19b are expressed in early stages of pregnancy. They are down-regulated in villous samples from early pregnancy loss. (PMID:23433743)
• Data indicate that miR-17-92 families miR-19b, miR-20a, miR-25 and miR-92a might implicate in apoptosis induction in the some of the cells and conditions. (PMID:23681423)
• MiR-19b and miR-146a are potential biomarkers for the prediction of survival and response to chemotherapy in non-small cell lung cancer. (PMID:24531034)
• miR-17-92 cluster members miR-19a/b facilitated gastric cancer cell migration, invasion and metastasis through targeting the antagonist of c-Myc – MXD1.[MIR19B] (PMID:24675462)
• miR-19b targets 3’UTR sequences of Mfn1 genes inhibit the expression of Mfn1 (PMID:24824927)
• Overexpression of miR-19b inhibited TF expression and procoagulant activity. (PMID:24998411)
• MiR-19b directly regulated endogenous ABCA1 expression levels in foam cells derived from human THP-1 macrophages. MiR-19b promotes macrophage cholesterol accumulation, foam cell formation and aortic atherosclerotic development by targeting ABCA1. (PMID:25084135)
• The CtIP 3’UTR is directly targeted by miR-19a and miR-19b. (PMID:25308476)
• The microRNA-19b (miR-19b) regulates hTERT expression and cell proliferation through inhibition of PITX1. (PMID:25643913)
• Expression level of miR-19b is downregulated in patients with idiopathic rapid eye movement behavior disorder. (PMID:25675938)
• Diosgenin enhances ABCA1-dependent cholesterol efflux and inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression. (PMID:25765596)
• Overexpression of miR-19b decreased SOCS3 expression, leading to increased production of macrophage-inflammatory protein-3alpha (MIP-3alpha) (PMID:25997679)
• MicroRNA-19b/221/222 have roles in endothelial cell dysfunction via suppression of PGC-1alpha in the progression of atherosclerosis (PMID:26117405)
• Upregulation of MicroRNA-19b predicts good prognosis in patients with hepatocellular carcinoma presenting with vascular invasion or multifocal disease (PMID:26453548)
• This study indicated that the elevation of microRNA-19b suppressed TSLP expression and then influenced T cell development in thymomatous Myasthenia gravis (PMID:26531692)
• Increased expression of miR-19b is associated with diffuse large B-Cell lymphoma. (PMID:26683099)
• Results show that plasma levels of miR-19b-3p, miR-134-5p and miR-186-5p were significantly increased in early stage of acute myocardial infarction. (PMID:26939053)
• Study determined that miR-19b-3p could regulate the expression of not only USP32, RAB18 and Dusp6 but also FXR1, and FXR1 could in turn regulate the expression of miR-19b-3p. (PMID:27138803)
• Data suggest that miR-19b contributes to irregular beating through regulation of GJA1 by cooperating with miR-1 which could indicate that miR-19b and miR-1 might be critically involved in cardiac arrhythmia associated with viral myocarditis. (PMID:27213338)
• Detection of microRNA miR-19b versus miR-16 in total vesicles and exosome-enriched fractions achieved 100%/93% and 95%/79% specificity/sensitivity in distinguishing cancer patients from healthy individuals, respectively, indicating the diagnostic value of urine extracellular vesicles. (PMID:27305142)
• The miR-19b-PTEN signaling pathway may serve as a novel therapeutic target in the context of ventilator-associated lung fibrosis. (PMID:27508324)
• miR-19b inhibits PTPRG expression to promote tumorigenesis in human breast cancer (PMID:27602768)
• Combination of miR-19b and miR-183 provided detection of lung cancer with 94.7% sensitivity and 95.2% specificity (PMID:27768748)
• Results show that miR-19b is upregulated in nasopharyngeal carcinoma (NPC) and contributes to the radioresistance of NPC by targeting the 3’-UTR of TNFAIP3 and consequently activating the NF-kappaB pathway. (PMID:27919278)
• miR-19b may be involved in Biliary Atresia -related Liver fibrosis. (PMID:28083843)
• decreased miR-19b may be involved in myocardial LOX up-regulation and excessive CCL, and consequently increased LV stiffness in AS patients, namely in those with HF. Serum miR-19b can be a biomarker of these alterations of the myocardial collagen network in AS patients, particularly in patients with HF. (PMID:28091585)
• The greatest levels of circulating miR-297 and miR-19b-3p with its common target CFL2 are associated with metastatic prostate cancer. (PMID:28091918)
• Mitochondria-targeted esculetin has anti-atherosclerotic effects by inhibiting PAI-1 levels by modulating miR-19b and -30c expression and affecting SIRT3- and STAT3-mediated signaling pathways. (PMID:28213977)
• the expression levels of miR-19b, miR-24, and miR-195 in serum may be useful for the diagnosis of Parkinson’s disease (PMID:28223160)
• findings have provided the first clues regarding the roles of miR-19a/b, which appear to function as oncomirs in lung cancer by downregulating MTUS1. (PMID:28364280)
• the serum levels of miR-29c-3p and miR-19b-3p are helpful biomarkers for Alzheimer’s disease. (PMID:28626163)
• upregualtion of PTENP1 could attenuate BC cell growth and metastasis, and induce apoptosis, possibly because it has a competing endogenous RNA role in reverse regulation of miRNA-19b, and then activation of PTEN, as well as modulation of PTEN/AKT/p53 signaling pathway (PMID:28731027)
• Study found that miR-19b-3p was significantly upregulated in colon cancer. This overexpression seems to play an important role in promoting colon cancer progression through enhanced proliferation and reduced chemosensitivity to oxaliplatin of colon cancer cells. (PMID:28938919)
• Serum exosomal miR-19b-3p expression is a biomarker for gastric cancer (PMID:28986250)
• miR-19b and miR-20a were highlighted for their high differential expression in extracellular vesicles related to sensitive or chemo-resistant acute myeloid leukemia cells (PMID:28987820)
• the present study revealed that increased miR19b expression may delay unstable plaque progression in patients with UA by inhibiting EC proliferation, migration and angiogenesis via the suppression of STAT3 transcriptional activity (PMID:29207010)
• findings suggest an important role of miR-19b-1 in crosstalk between metastatic breast cancer and endothelial cells and provide us new insights for exploring miR-19b-1 and its multiple targets as promising therapeutic candidates to interfere breast cancer progression. (PMID:29425833)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-19a	ENSDARG00000099103
danio_rerio	dre-mir-19b	ENSDARG00000100273
mus_musculus	Mir19b-1	ENSMUSG00000076256
rattus_norvegicus	Mir19b1	ENSRNOG00000035462

Paralogs (2): MIR19B2 (ENSG00000284107), MIR19A (ENSG00000284204)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.