MIR19B2

Summary

MIR19B2 (microRNA 19b-2, HGNC:31576) is a microRNA gene on chromosome Xq26.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406981 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31576
Approved symbol	MIR19B2
Name	microRNA 19b-2
Location	Xq26.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-19b-2
Ensembl gene	ENSG00000284107
Ensembl biotype	miRNA
OMIM	300722
Entrez	406981
RNAcentral	URS0000204276 — miRNA, 96 nt, 14 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385077

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385077 — 1 exons

Exon	Start	End
ENSE00001500083	134169671	134169766

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 70.84.

Top tissues by expression

1 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	70.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• Data indicate that miR-17-92 families miR-19b, miR-20a, miR-25 and miR-92a might implicate in apoptosis induction in the some of the cells and conditions. (PMID:23681423)
• MiR-19b directly regulated endogenous ABCA1 expression levels in foam cells derived from human THP-1 macrophages. MiR-19b promotes macrophage cholesterol accumulation, foam cell formation and aortic atherosclerotic development by targeting ABCA1. (PMID:25084135)
• Diosgenin enhances ABCA1-dependent cholesterol efflux and inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression. (PMID:25765596)
• miR-19b inhibits PTPRG expression to promote tumorigenesis in human breast cancer (PMID:27602768)
• Mitochondria-targeted esculetin has anti-atherosclerotic effects by inhibiting PAI-1 levels by modulating miR-19b and -30c expression and affecting SIRT3- and STAT3-mediated signaling pathways. (PMID:28213977)
• The pathway enrichment analysis suggested that this miRNA participated in several metabolic pathways which could be a key to the regulation of the mitochondrial gene expression and biogenesis. In addition, this miRNA targets a total of 112 mitochondria-related genes, establishing further the crucial role of the candidate miRNA in mitochondrial biology. (PMID:29674166)
• Our study demonstrated that miR-19b alleviated lipopolysaccharide-induced Caco2 cell inflammatory injury via up-regulation of Runx3 and deactivation of NF-kappaB and PI3K/AKT signaling pathways (PMID:30178853)
• Our finding reveals a novel function of AGO2 acetylation in increasing oncogenic miR-19b biogenesis and suggests that modulation of AGO2 acetylation has potential clinical implications. (PMID:30305728)
• Circulating MicroRNA-19b Identified From Osteoporotic Vertebral Compression Fracture Patients Increases Bone Formation. (PMID:31614022)
• miR-16-5p and miR-19b-3p prevent amyloid beta-induced injury by targeting BACE1 in SH-SY5Y cells. (PMID:31876684)
• Overexpression of PTEN regulated by miR-19b and miR-494 in the villous of recurrent spontaneous abortion patients. (PMID:32353660)
• Regulation of the miR-19b-mediated SOCS6-JAK2/STAT3 pathway by lncRNA MEG3 is involved in high glucose-induced apoptosis in hRMECs. (PMID:32519748)
• Diagnostic value of circulating microRNA-19b in heart failure. (PMID:32663314)
• Novel circRNA_0071196/miRNA19b3p/CIT axis is associated with proliferation and migration of bladder cancer. (PMID:32705161)
• miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes. (PMID:32949564)
• The Potential Role of miRNA-19b-3p and miRNA-320c in Patients with Moderate Bronchial Asthma. (PMID:33632094)
• Human Antigen R (HuR) Facilitates miR-19 Synthesis and Affects Cellular Kinetics in Papillary Thyroid Cancer. (PMID:35352515)
• c-Jun-mediated miR-19b expression induces endothelial barrier dysfunction in an in vitro model of hemorrhagic shock. (PMID:36224531)
• MiR-19 Family Impairs Adipogenesis by the Downregulation of the PPARgamma Transcriptional Network. (PMID:36555437)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir19b-2	ENSMUSG00000065473

Paralogs (2): MIR19A (ENSG00000284204), MIR19B1 (ENSG00000284375)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.