MIR200C

Summary

MIR200C (microRNA 200c, HGNC:31580) is a microRNA gene on chromosome 12p13.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406985 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31580
Approved symbol	MIR200C
Name	microRNA 200c
Location	12p13.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-200c
Ensembl gene	ENSG00000207713
Ensembl biotype	miRNA
OMIM	612092
Entrez	406985
RNAcentral	URS0000171525 — miRNA, 68 nt, 21 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384980

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384980 — 1 exons

Exon	Start	End
ENSE00001499987	6963699	6963766

Expression profiles

Bgee: expression breadth broad, 41 present calls, max score 91.38.

Top tissues by expression

41 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
epididymis	UBERON:0001301	91.38	gold quality
placenta	UBERON:0001987	89.47	gold quality
renal glomerulus	UBERON:0000074	84.87	gold quality
adrenal gland	UBERON:0002369	82.24	gold quality
spleen	UBERON:0002106	79.98	gold quality
fundus of stomach	UBERON:0001160	76.83	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.99	gold quality
monocyte	CL:0000576	73.35	gold quality
body of pancreas	UBERON:0001150	73.23	gold quality
islet of Langerhans	UBERON:0000006	73.17	gold quality
uterus	UBERON:0000995	72.45	gold quality
endometrium	UBERON:0001295	72.45	gold quality
blood	UBERON:0000178	72.01	gold quality
body of stomach	UBERON:0001161	70.92	gold quality
fallopian tube	UBERON:0003889	69.53	gold quality
zone of skin	UBERON:0000014	69.29	gold quality
skin of abdomen	UBERON:0001416	68.75	gold quality
skin of leg	UBERON:0001511	68.54	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.76	gold quality
cerebellar hemisphere	UBERON:0002245	67.03	gold quality
transverse colon	UBERON:0001157	67.01	gold quality
left uterine tube	UBERON:0001303	66.76	gold quality
esophagus mucosa	UBERON:0002469	66.07	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.48	gold quality
small intestine	UBERON:0002108	64.77	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.71	gold quality
prostate gland	UBERON:0002367	64.26	gold quality
vagina	UBERON:0000996	64.19	gold quality
pituitary gland	UBERON:0000007	63.88	gold quality
upper lobe of left lung	UBERON:0008952	63.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.35

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): NR0B2, NR5A2, PPARA

Literature-anchored findings (GeneRIF, showing 40)

• Loss of miR-200c expression could play a significant role in the initiation of an invasive phenotype, and, equally, miR-200c overexpression holds potential for its reversal. (PMID:17804704)
• The cells expressing miR-200c had a significantly altered morphology from mesenchymal to epithelial and restored expression of E-cadherin. (PMID:19502803)
• miR-200c strongly suppressed the ability of normal mammary stem cells to form mammary ducts and tumor formation driven by human breast cancer stem cells in vivo. (PMID:19665978)
• Data show that three members of the microRNA-200 family, miR200b, miR200c, and miR429 were predicted to have the highest scores. (PMID:19801681)
• Since the miR-200c cluster plays a significant role in EMT, our results suggest an important role for DNA methylation in the control of phenotypic conversions in normal cells (PMID:20084174)
• miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer. (PMID:20514023)
• miR-200c sensitizes cells to apoptosis mediated by CD95. (PMID:20620960)
• The loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer. (PMID:20696752)
• miR-200 family controls beta-tubulin III expression and is associated with paclitaxel-based treatment response and progression-free survival in ovarian cancer. (PMID:21051560)
• miR-200c and miR-141 directly inhibited JAGGED1, impeding proliferation of human metastatic prostate cancer cells (PMID:21224847)
• The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. (PMID:21224848)
• We found a significant down-regulation of the miR-200 family and miR-205, loss of desmosomal cadherins, and an altered expression of classic cadherins in spindle cell carcinoma (PMID:21237487)
• Involvement of miR-200c in resistance to chemotherapy among esophageal cancers and this effect was mediated through the Akt pathway. (PMID:21248297)
• study suggests that the expression of miR-200c in patients with stage I epithelial ovarian cancer correlates with disease outcome (PMID:21345725)
• miR-200c maintains the epithelial phenotype not only by targeting ZEB1/2, but also by actively repressing a program of mesenchymal and neuronal genes involved in cell motility and anoikis resistance (PMID:21501518)
• High expression of serum MIR200C is associated with lung cancer. (PMID:21516486)
• ZEB1 knockdown recapitulated miR-200c-induced responses, and expression of a ZEB1 allele non-targeted by miR-200c, prevented miR-200c phenotype. (PMID:21527937)
• HKe3 cells stably overexpressing oncogenic KRAS showed increased expression of miR-200c, miR-221 and miR-222 and reduced expression of its target PTEN exclusively in 3D culture. These miRNAs were also overexpressed in colorectal tumor specimens. (PMID:21873159)
• results suggest that miR-200c and miR-27b downregulated by HGF might play an important role for EMT and ECM degradation with HGF autoactivation followed by enhanced invasive characteristics of squamous cell carcinoma of the head and neck (PMID:21899661)
• miR-200c inhibits the expression of BRD7. MiR-200c regulated the translocation of beta-catenin from the cytoplasm to the nucleus via inhibition of BRD7, resulting in increased expression of its transcriptional target genes, cyclinD1 and c-myc. (PMID:22015043)
• This is the first report to demonstrate that miR-200c expression is controlled by nuclear receptors. (PMID:22100809)
• study demonstrated that restoration of miR-200c in MCF-7/ADR cells could increase intracellular doxorubicin accumulation determined by flow cytometry (PMID:22101791)
• FHOD1 and PPM1F (direct regulators of the actin cytoskeleton) were identified as novel targets of miR-200c. Expression levels of FHOD1 and PPM1F were inversely correlated with miR-200c level in breast cancer cell lines and breast cancer patient samples. (PMID:22144583)
• We demonstrated that miRNAs were dysregulated in conjunctival MALT lymphoma, and dysregulation of the miR-200 family could be involved in the pathogenesis and progression of the disease. (PMID:22183793)
• identified a series of differentially expressed miRNAs that could be useful as diagnostic or prognostic markers for melanoma and have shown that three miRNAs (namely miR-200c, miR-205 and miR-211) act as tumour suppressors (PMID:22223089)
• IL6-mediated suppression of miR-200c directs constitutive activation of inflammatory signaling circuit driving transformation and tumorigenesis. (PMID:22364742)
• p300 and PCAF cooperate in the control of microRNA 200c/141 transcription and epithelial characteristics (PMID:22384255)
• Loss of miR-200c is associated with colon cancer. (PMID:22407310)
• These data define miR-200b and miR-200c as factors that modify the efficiency of TLR4 signaling through the MyD88-dependent pathway and can thus affect host innate defenses against microbial pathogens. (PMID:22522429)
• our results thus suggest that the overexpression of miR-34a, miR-155 and miR-200c be associated with the development of colorectal cancer (PMID:22562822)
• show that miR-200c is a novel negative regulator of the pro-apoptotic Bcl-2 family member Noxa (PMID:22615771)
• increased miR-181a, miR-200c and miR-210 expression was only observed in 3D cultures of human colorectal cancer cells (PMID:22641662)
• Altered expression of miR-200c may have a significant impact on the outcome of leiomyomas growth, maintenance of their mesenchymal and fibrotic characteristics, and possibly their associated symptoms. (PMID:22685266)
• Our findings are consistent with the hypothesis supporting the pivotal role of miR-200c in the aggressive progression of stem-like intrahepatic cholangiocarcinoma. (PMID:22707408)
• miR-200c plays an important role in mediating epithelial-to-mesenchymal transition and metastatis in the colon and may serve as a potential diagnostic marker and therapeutic target for patients with colorectal cancer. (PMID:22735571)
• These data suggest that increased miR-200c levels are detected in the blood of gastric cancer patients. MiR-200c has the potential to be a predictor of progression and survival (PMID:22954417)
• miR-200c overexpression resulted in significant down-regulation of BMI-1. (PMID:22982443)
• miR-200c overexpression could increase radiosensitivity in breast cancer cells by inhibiting cell proliferation, and by increasing apoptosis and DNA double-strand breaks. (PMID:22991189)
• A significantly reduced expression of microRNA (miR)-200c and miR-205 in docetaxel-resistant cells, is reported. (PMID:23041061)
• G-A variant in miR-200c binding site of EFNA1 alters susceptibility to gastric cancer. (PMID:23065816)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir200c	ENSMUSG00000065462
rattus_norvegicus	Mir3575	ENSRNOG00000035587

Paralogs (2): MIR200A (ENSG00000207607), MIR200B (ENSG00000207730)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.