MIR202

Summary

MIR202 (microRNA 202, HGNC:32080) is a microRNA gene on chromosome 10q26.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574448 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32080
Approved symbol	MIR202
Name	microRNA 202
Location	10q26.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-202
Ensembl gene	ENSG00000284219
Ensembl biotype	miRNA
Entrez	574448
RNAcentral	URS000075BC7D — miRNA, 110 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362219

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362219 — 1 exons

Exon	Start	End
ENSE00001436982	133247511	133247620

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 95.19.

Top tissues by expression

60 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left adrenal gland cortex	UBERON:0035825	95.19	gold quality
right adrenal gland cortex	UBERON:0035827	94.09	gold quality
left adrenal gland	UBERON:0001234	94.07	gold quality
right adrenal gland	UBERON:0001233	93.95	gold quality
adrenal gland	UBERON:0002369	92.65	gold quality
right testis	UBERON:0004534	89.18	gold quality
left ovary	UBERON:0002119	87.26	gold quality
testis	UBERON:0000473	85.65	gold quality
ovary	UBERON:0000992	85.44	gold quality
left testis	UBERON:0004533	85.44	gold quality
right ovary	UBERON:0002118	82.04	gold quality
urinary bladder	UBERON:0001255	77.30	gold quality
adrenal tissue	UBERON:0018303	76.68	gold quality
body of pancreas	UBERON:0001150	73.11	gold quality
heart left ventricle	UBERON:0002084	72.90	gold quality
gastrocnemius	UBERON:0001388	72.77	gold quality
tibial artery	UBERON:0007610	70.88	gold quality
left coronary artery	UBERON:0001626	70.67	gold quality
heart	UBERON:0000948	70.30	gold quality
right lobe of liver	UBERON:0001114	70.30	gold quality
body of stomach	UBERON:0001161	69.66	gold quality
putamen	UBERON:0001874	69.57	gold quality
blood	UBERON:0000178	69.15	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.79	gold quality
caudate nucleus	UBERON:0001873	68.65	gold quality
omental fat pad	UBERON:0010414	68.45	gold quality
right atrium auricular region	UBERON:0006631	68.23	gold quality
ascending aorta	UBERON:0001496	67.95	gold quality
body of uterus	UBERON:0009853	67.85	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Loss of miR-202 expression is associated with lymphomagenesis. (PMID:23334589)
• The transcriptional factor Gli1 was a target of miR-202-3p and plays an essential role as a mediator of the biological effects of miR-202-3p in gastric cancer. (PMID:23936094)
• The relative expression of serum miR-202 in patients was significantly higher in multiple myeloma than that in healthy controls. (PMID:24048721)
• microRNA-202-3p inhibits cell proliferation by targeting ADP-ribosylation factor-like 5A in human colorectal carcinoma. (PMID:24327274)
• miR202 is activated by E2F1 and in turn downregulates MYCN protein expression in the neuroblastoma cell line LAN5. Upregulation of miR202 may therefore be a novel strategy for neuroblastoma treatment. (PMID:24337320)
• Data indicate that miR-202 suppresses the expression of LRP6 (low-density lipoprotein receptor-related protein 6) by binding to the 3’-untranslated region (UTR) of its mRNA. (PMID:24704686)
• This study provides novel insight into the role of miRNA in cerebellar degeneration and suggests that miR-202 is a key miRNA mediating the pathogenesis of multiple-system atrophy. (PMID:24981430)
• The levels of miR-202 were elevated. (PMID:24983365)
• results indicate that miR-202 acts as a novel tumor suppressor to regulate OS cell proliferation and apoptosis through downregulating Gli2 expression. (PMID:25156120)
• down regulation of miR-202 increased the expression of its target Mxd1, followed by Mxd1 recruitment to the Sin3A repressor complex and through its dimerization with Max, and increased repression of Myc-Max target proteins. (PMID:25611699)
• These results suggest that miR-202 functions as a modulator that can negatively regulate BAFF by inhibiting multiple myeloma tumor cell survival, growth, and adhesion in the bone marrow microenvironment. (PMID:25971527)
• High miR202 increases osteosarcoma cells resistance to apoptosis. (PMID:26276504)
• Taken together, these findings suggest that miR-202 may function as a novel tumor suppressor in ESCC by repressing cell proliferation and migration, and its biological effects may attribute the inhibition of LAMA1-mediated FAK-PI3K-Akt signaling. (PMID:27045085)
• miR-202 plays an important role in regulating cell proliferation, migration and invasion of cervical cancer by directly targeting cyclin D1. (PMID:27732565)
• MALAT1 promotes gastric cancer proliferation and progression. MALAT1 is a direct target of miR-202 and knockdown of MALAT1 significantly decreases the expression of Gli2 by negatively regulating miR-202. (PMID:27887846)
• MiR-202-3p may function as a novel pro-fibrotic miRNA in SSc by inhibition the expression of MMP1. (PMID:28068631)
• in silico analyses suggested theG>C change of rs3821204, which located within the 3’UTR of soluble ST2 mRNA, disrupted a putative binding site for miR202-3p. Functional analyses suggested that miR-202-3p significantly decreased soluble ST2-G mRNA stability and inhibited its endogenous expression.our findings provide the first evidence that genetic variants in ST2 gene are associated with EH risk (PMID:28121058)
• Genetic polymorphism in miRNA202 is involved in hBD1 salivary level as well as caries experience in children. (PMID:28343232)
• DZNep induced miR-202-5p to target both TGFbeta receptors, TGFBR1 and TGFBR2…transfection of anti-miRNAs against miR-202-5p resulted in increased TGFBR1 and TGFBR2 protein expressions and induced EMT characteristics in these cells. In stellate pancreatic cells, miR-202 overexpression slowed growth as well as reduced stromal extracellular membrane matrix protein expression (PMID:28373289)
• expression of miR-202 was different in the skin tissue of C57BL/6 black mice and BALB/c white mice and that wnt5a, kit, and tcf7 are negatively regulated by miR-202 (PMID:28430525)
• miR-202 may function as a tumor suppressor in endometrial adenocarcinoma tumor growth by targeting FOXR2 oncogene. (PMID:28827892)
• MiR-202-3p is expressed early in gestations that develop severe preeclampsia. (PMID:29153693)
• Low miR202 expression is associated with Bladder Cancer. (PMID:29298735)
• miR-202-3p is upregulated in type 1 gastric neuroendocrine neoplasms (g-NENs) lesions and might play important roles in the pathogenesis of type 1 g-NENs by targeting DUSP1. (PMID:29434446)
• we provided the clinical relevance that miR-202 was down-regulated in Chronic myeloid leukemia (CML) patients and patients with lower miR-202 expression displayed higher HK2 expression. (PMID:29559564)
• The allelic distribution of the polymorphism rs12355840 in miRNA202 was associated with caries experience in the Brazilian Manaus group. In the Ribeirao Preto group, the allelic and genotypic distributions in the polymorphism rs11362 in DEFB1 were associated with caries experience. (PMID:29727722)
• Study demonstrated that miR-202-5p was a tumor-suppressive miRNA in colorectal carcinoma (CRC) progression. Also, the expression of miR-202-5p was obviously decreased in CRC tissues and associated with postoperative survival. Its overexpression inhibited the growth and metastasis of CRC cells. (PMID:30144500)
• miR-202-5p could target MATN2 to induce M2 polarization involved in allergic rhinitis. (PMID:30408806)
• Low miR202 expression is associated with severe degenerative disc. (PMID:30458287)
• A significant decrease in miR-202 expression was observed in Non-Small Cell Lung Cancer cells both in vivo and in vitro. In addition, miR-202 expression was associated with drug resistance. (PMID:30522099)
• that NORAD has a tumor-promoting effect in hepatocellular carcinoma and describes a novel mechanism whereby NORAD regulates the TGF-beta pathway as a ceRNA of Homo sapiens (hsa)-miR-202-5p (PMID:30537113)
• Augmentation of miR-202 in varicose veins modulates phenotypic transition of vascular smooth muscle cells by targeting proliferator-activated receptor-gamma coactivator-1alpha. (PMID:30556158)
• We confirmed that MALAT1 positively regulated the expression of periostin by negatively modulating miR-202-3p. In addition, the MALAT1/miR-202-3p/periostin axis was deeply associated with the regulation of the cell viability, cell migration and invasion, and EMT in cervical cancer (CC) cells. (PMID:30633360)
• Overexpression of miR-202-3p inhibited cell migration and invasion in TPC-1 and BCPAP cells. (PMID:30779083)
• miR-202-5p was high-expressed in breast cancer tissues and cells, targeted and downregulated PTEN expression. DOX-resistance of breast cancer cells was enhanced by miR-202-5p through PTEN/PI3K/Akt signaling (PMID:30983514)
• Results indicate that miR-202 inhibits the proliferation and invasion of colorectal cancer (CRC) via targeting ubiquitin-like with PHD and RING finger domain 1 (UHRF1). (PMID:31058289)
• MiR-202 inhibits cell proliferation, invasion, and migration in breast cancer by targeting ROCK1 gene. (PMID:31106468)
• Results identified hsa-miR-202 as a potential negative regulator of PARN. (PMID:31448843)
• MiR-202-5p/MATN2 are associated with regulatory T-cells differentiation and function in allergic rhinitis. (PMID:31493245)
• Results found that miR-202 expression in peripheral blood was significantly higher in patients with coronary heart disease (CHD) than in matched controls. miR-202-3 was associated with CHD, exerting a protective role against CHD by feedback suppression of ox-LDL-induced macrophage foam cell formation. (PMID:31956131)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.