MIR203A

Summary

MIR203A (microRNA 203a, HGNC:31581) is a microRNA gene on chromosome 14q32.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406986 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31581
Approved symbol	MIR203A
Name	microRNA 203a
Location	14q32.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-203
Ensembl gene	ENSG00000207568
Ensembl biotype	miRNA
OMIM	611899
Entrez	406986
RNAcentral	URS000075ACBD — miRNA, 110 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384836

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384836 — 1 exons

Exon	Start	End
ENSE00001499843	104117405	104117514

Expression profiles

Bgee: expression breadth broad, 44 present calls, max score 97.10.

Top tissues by expression

44 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	97.10	gold quality
ectocervix	UBERON:0012249	94.27	gold quality
skin of leg	UBERON:0001511	87.24	gold quality
left ovary	UBERON:0002119	86.90	gold quality
zone of skin	UBERON:0000014	86.69	gold quality
skin of abdomen	UBERON:0001416	85.80	gold quality
esophagus mucosa	UBERON:0002469	82.58	gold quality
tibial nerve	UBERON:0001323	80.34	gold quality
vagina	UBERON:0000996	78.18	gold quality
body of pancreas	UBERON:0001150	77.05	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	76.99	gold quality
minor salivary gland	UBERON:0001830	76.85	gold quality
lower esophagus muscularis layer	UBERON:0035833	75.08	gold quality
monocyte	CL:0000576	73.82	gold quality
subcutaneous adipose tissue	UBERON:0002190	73.32	gold quality
right lobe of liver	UBERON:0001114	72.83	gold quality
body of stomach	UBERON:0001161	72.44	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.15	gold quality
stomach	UBERON:0000945	71.75	gold quality
blood	UBERON:0000178	71.58	gold quality
caudate nucleus	UBERON:0001873	70.73	gold quality
tibial artery	UBERON:0007610	69.95	gold quality
small intestine Peyer’s patch	UBERON:0003454	69.18	gold quality
upper lobe of left lung	UBERON:0008952	68.73	gold quality
thoracic mammary gland	UBERON:0005200	68.30	gold quality
ascending aorta	UBERON:0001496	68.26	gold quality
transverse colon	UBERON:0001157	66.63	gold quality
mucosa of transverse colon	UBERON:0004991	65.82	gold quality
fundus of stomach	UBERON:0001160	65.72	gold quality
left lobe of thyroid gland	UBERON:0001120	64.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): AP1, JUN, SNAI2, TP53, TP63, ZEB1

Literature-anchored findings (GeneRIF, showing 40)

• Data suggest that miR-203, a keratinocyte-specific miRNA that is specifically upregulated in psoriasis, plays a specific role in the pathogenesis of psoriasis by regulating inflammation-, proliferation- and morphogenesis-associated processes in the skin. (PMID:17622355)
• By targeting deltaNp63, miR-203 acts as a switch between keratinocyte proliferation and differentiation. (PMID:18483491)
• study provides the first evidence for an oncogenic activity of miR-155, miR-203, miR-210 and miR-222 in the development of pancreatic cancer as has been reported for other tumor types (PMID:19551852)
• upregulation of miR-203 in human keratinocytes is required for their differentiation and is dependent on the activation of the PKC/AP-1 pathway (PMID:19759552)
• miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. (PMID:19843643)
• The authors conclude that high levels of miR-203 are inhibitory to human papillomavirus amplification and that human papillomavirus proteins act to suppress expression of this microRNA to allow productive replication in differentiating cells. (PMID:20219920)
• miR-203 overexpression is associated with pancreatic adenocarcinoma. (PMID:20652642)
• involved in skin morphogenesis (PMID:20698882)
• expression of miR-203 is dependent on p53, which may explain how expression of HPV16 E6 can disrupt the balance between proliferation and differentiation, as well as the response to DNA damage, in keratinocytes (PMID:20702634)
• miR-203 may be related to the proliferation and invasion of gastric and colorectal cancers. (PMID:21063914)
• Data indicate that survivin is a direct target of miR-203. (PMID:21159887)
• The data suggest an important role for miR-203 in the molecular etiology of bladder cancer and implicate the potential application of miR-203 in bladder cancer therapy. (PMID:21205209)
• Data implied that miR-203 could inhibit cell proliferation in human ESCC through DeltaNp63-mediated signal pathway. (PMID:21299870)
• Epigenetic inactivation of the hsa-miR-203 is associated with hematological malignancies. (PMID:21323860)
• Overexpression of miR-203 reverses chemoresistance in p53-mutated colon cancer cells through downregulation of Akt2 expression. (PMID:21354697)
• MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines. (PMID:21368580)
• transformation from gastritis to MALT lymphoma is epigenetically regulated by miR-203 promoter methylation; ABL1 is a novel target for the treatment of this malignancy (PMID:21454413)
• miRNA-203 was was upregulated 4-fold compared to uninfected controls by gingival epithelial cells in the presence of P. gingivalis; results show that miRNAs such as miR-203 make important contributions to host cell responses to P. gingivalis (PMID:21536793)
• role of miR-203 during the entire process of epidermal development by extending its spectrum of action from the early commitment of embryonic stem cells to ultimate differentiation of the organ. (PMID:21684271)
• MIR203 methylation occurred in 25.0% monoclonal gammopathy of undetermined significance, 23.6% diagnostic multiple myeloma (MM), and 21.1% relapsed MM samples (PMID:21707582)
• Our results suggest that miR-203 could be a novel prognostic marker in hepatocellular carcinoma patients who have undergone liver transplantation (PMID:21786180)
• Downregulation of microRNA-203 is associated with bladder cancer. (PMID:21836020)
• Increased expression of miR-203 was seen in OLP compared to normal oral mucosa. Results indicate a role for the studied microRNAs in changes seen in OLP. (PMID:21943223)
• DNA methylation of miR-34a, -34b/c, -124-1 and -203 in Philadelphia-negative (Ph-ve) myeloproliferative neoplasms, was studied. (PMID:22082000)
• Epstein-Barr virus promotes malignancy by downregulating cellular microRNA 203 through LMP1. (PMID:22205737)
• study indicates that miR-203 exerts a tumor-suppressive effect during laryngeal carcinogenesis via suppressing the expression of survivin (PMID:22306317)
• a novel role for miR-203 as a tumor suppressor acting by inducing senescence in melanoma cells. (PMID:22354972)
• microRNAs that jointly act as tumor suppressors in prostate carcinoma (PMID:22391564)
• Data propose a novel EMT core network integrating two fundamental negative feedback loops, miR203/SNAI1 and miR200/ZEB. (PMID:22514743)
• AQP4 gene expression was significantly higher in miRNA-203 down-regulated asthmatic airway epithelia. (PMID:22679274)
• Differential expression of microRNAs miR-21, miR-31, miR-203, miR-125a-5p and miR-125b and proteins PTEN and p63 in verrucous carcinoma of the head and neck. (PMID:22690848)
• Data suggest that miR-203 may function as a tumor suppressor in triple negative breast cancer cells. (PMID:22713668)
• miR-203 overexpression significantly inhibited survivin expression in HepG2 cells, while underexpression of miR-203 significantly promoted it. Low miR-203 expression contributes to the progression of hepatocellular carcinoma via targeting survivin. (PMID:22886454)
• results demonstrate the inflammatory cytokines TNFalpha and IL24 are direct targets of miR-203 in keratinocytes; findings suggest miR-203 serves to fine-tune cytokine signaling and may dampen skin immune responses by repressing key pro-inflammatory cytokines (PMID:22917968)
• miR-203 inhibits the migration and invasion of esophageal squamous cell carcinoma by regulating LASP1. (PMID:22940702)
• expression of miR-203 is downregulated in lung cancer cells; miR-203 negatively regulates survivin protein expression and inhibits the proliferation and invasion of lung cancer cells (PMID:23073851)
• MiR-203 controlling the expression of target proteins contributes to skin re-epithelialization. (PMID:23190607)
• By lowering Hakai abundance, miR-203 also reduces Hakai-regulated-cell division. (PMID:23285092)
• miR-182 and miR-203 induce mesenchymal to epithelial transition features and growth factor independent growth via repressing SNAI2 in prostate cells. (PMID:23354685)
• study identified two miRNAs (miR-21* and miR-203 that are differentially expressed in papillary thyroid carcinoma tissues with BRAF(V600E) and revealed their associations with clinicopathological features (PMID:23416953)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.