MIR203B

Summary

MIR203B (microRNA 203b, HGNC:41811) is a microRNA gene on chromosome 14q32.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616173 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41811
Approved symbol	MIR203B
Name	microRNA 203b
Location	14q32.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-3545
Ensembl gene	ENSG00000283165
Ensembl biotype	miRNA
Entrez	100616173
RNAcentral	URS000075A5EE — miRNA, 86 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636080

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636080 — 1 exons

Exon	Start	End
ENSE00003798327	104117418	104117503

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 69.54.

Top tissues by expression

1 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
zone of skin	UBERON:0000014	69.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 24)

• miR-203 inhibits renal cancer cell proliferation, migration and invasion by post-transcriptionally targeting FGF2. (PMID:25890121)
• Suggest miR-203 and miR-210 are key regulators in normal and sulfur mustard-impaired keratinocyte functionality. (PMID:26383628)
• miR-203 represses NF-kappaB signaling via targeting TAK1 and PI3KCA and miR-203 overexpression may contribute to the COPD initiation. (PMID:26617776)
• MiR-203 may contribute to the metastasis and enhance apoptosis of hepatocellular carcinoma cells by regulating EZH2 and Bmi-1 expression. (PMID:26715809)
• miR-203a and miR-203b are downregulated in GCA, and proximal promoter hypermethylation may be responsible for the downregulation of miR-203a and miR-203b in GCA. (PMID:27791400)
• miR-203 induces the apoptosis of YD-38 human oral cancer cells by directly targeting SEMA6A. (PMID:28982852)
• The BMI1 mRNA and protein were upregulated in hepatocellular carcinoma (HCC) tissues. BMI1 overexpression was an independent prognostic parameter for HCC patients. The expression level of BMI1 was negatively associated with miR-203 levels in HCC tissues. Dual-luciferase reporter assays showed that miR-203 could target the 3’ untranslated region of BMI1 directly. (PMID:29906128)
• Low expression of microRNA-203 promotes the invasion and inhibits the apoptosis of laryngeal cancer cells by inhibiting LASP1. (PMID:30338803)
• Long noncoding RNA B3GALT5-AS1 suppresses colon cancer liver metastasis via repressing expression of microRNA-203. (PMID:30530918)
• Serum miR-203 expression negatively correlated with pre-operative psoas muscle mass index (PMI) level, and multivariate logistic regression analysis revealed that elevated serum miR-203 was an independent risk factor for myopenia (low PMI) in colorectal cancer patients. Overexpression of miR-203 inhibited cell proliferation and induced apoptosis via down-regulation of BIRC5 (survivin) expression in human SkMC line. (PMID:31091026)
• Mechanism of epithelialmesenchymal transition inhibited by miR203 in nonsmall cell lung cancer. (PMID:31894278)
• MiR-203 is critical in the onset and progression of osteoarthritis (OA), at least in part, caused by estrogen deficiency and ERalpha instability in OA patients. (PMID:31894489)
• LINC00887 regulates the proliferation of nasopharyngeal carcinoma via targeting miRNA-203b-3p to upregulate NUP205. (PMID:32964975)
• Role of mir-33a, mir-203b, mir361-3p, and mir-424 in hepatocellular carcinoma (PMID:33098283)
• miR-203 inhibits cell proliferation and ERK pathway in prostate cancer by targeting IRS-1. (PMID:33109107)
• Evaluation of serum and gingival crevicular fluid microRNA-223, microRNA-203 and microRNA-200b expression in chronic periodontitis patients with and without diabetes type 2. (PMID:33157494)
• Human umbilical vein endothelial cells-derived microRNA-203-containing extracellular vesicles alleviate non-small-cell lung cancer progression through modulating the DTL/p21 axis. (PMID:33558703)
• Crosstalk between miR-203 and PKCtheta regulates breast cancer stem cell markers. (PMID:33576006)
• ITPKA induces cell senescence, inhibits ovarian cancer tumorigenesis and can be downregulated by miR-203. (PMID:33879633)
• Tear miRNA expression analysis reveals miR-203 as a potential regulator of corneal epithelial cells. (PMID:34696757)
• Comprehensive miRNA and DNA Microarray Analyses Reveal the Response of Hepatic miR-203 and Its Target Gene to Protein Malnutrition in Rats. (PMID:35052415)
• miRNA-203b-3p Induces Acute and Chronic Pruritus through 5-HTR2B and TRPV4. (PMID:36049541)
• miR-203 suppresses pancreatic cancer cell proliferation and migration by modulating DUSP5 expression. (PMID:36183924)
• Biological functions of miRNA-203b-3p/ZNF324 in laryngeal carcinoma. (PMID:38279443)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir203a	ENSDARG00000081779
danio_rerio	mir203b	ENSDARG00000083357
mus_musculus	Mir203	ENSMUSG00000065574

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.