MIR204

Summary

MIR204 (microRNA 204, HGNC:31582) is a microRNA gene on chromosome 9q21.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406987 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31582
Approved symbol	MIR204
Name	microRNA 204
Location	9q21.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-204
Ensembl gene	ENSG00000207935
Ensembl biotype	miRNA
OMIM	610942
Entrez	406987
RNAcentral	URS000039AE8A — miRNA, 110 nt, 54 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385200

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385200 — 1 exons

Exon	Start	End
ENSE00001500206	70809975	70810084

Expression profiles

Bgee: expression breadth broad, 45 present calls, max score 78.87.

Top tissues by expression

45 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	78.87	gold quality
monocyte	CL:0000576	74.48	gold quality
blood	UBERON:0000178	73.52	gold quality
subcutaneous adipose tissue	UBERON:0002190	72.68	gold quality
caudate nucleus	UBERON:0001873	72.19	gold quality
omental fat pad	UBERON:0010414	69.91	gold quality
ascending aorta	UBERON:0001496	69.87	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.50	gold quality
urinary bladder	UBERON:0001255	69.07	gold quality
kidney	UBERON:0002113	68.77	gold quality
body of stomach	UBERON:0001161	68.67	gold quality
heart	UBERON:0000948	68.17	gold quality
fundus of stomach	UBERON:0001160	67.78	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.64	gold quality
esophagus mucosa	UBERON:0002469	67.22	gold quality
liver	UBERON:0002107	67.11	gold quality
skin of abdomen	UBERON:0001416	66.71	gold quality
transverse colon	UBERON:0001157	66.58	gold quality
midbrain	UBERON:0001891	66.55	gold quality
substantia nigra	UBERON:0002038	66.55	gold quality
cerebellum	UBERON:0002037	66.05	gold quality
cerebellar hemisphere	UBERON:0002245	66.05	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.81	gold quality
skin of leg	UBERON:0001511	65.70	gold quality
ectocervix	UBERON:0012249	65.61	gold quality
uterus	UBERON:0000995	65.59	gold quality
hypothalamus	UBERON:0001898	65.58	gold quality
stomach	UBERON:0000945	65.53	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.39	gold quality
right atrium auricular region	UBERON:0006631	65.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.43

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• these data indicate a critical role for miR-204/211 in maintaining epithelial barrier function and cell physiology. (PMID:20056717)
• MiR-204 may protect cardiomyocytes against autophagy by regulating light chain (LC)3-II protein during hypoxia-reoxygenation. (PMID:21316776)
• regulatory pathway is critical to the etiology of pulmonary arterial hypertension (PMID:21321078)
• Functional analysis revealed the involvement of FOXC1 in migration and invasion of HEC1A cells. Our results present dysfunctional miRNAs in endometrial cancer and identify a crucial role for miR-204-FOXC1 interaction in endometrial cancer progression (PMID:21400511)
• PDEF is a negative regulator of prostate tumor progression and that the miR-204-PDEF regulatory axis contributes to PDEF protein loss and resultant cancer progression. (PMID:21446014)
• MIR-204 is a VHL-regulated tumor suppressor acting by inhibiting macroautophagy, with MAP1LC3B (LC3B) as a direct and functional target. (PMID:22516261)
• MITF is a key regulator of RPE differentiation that was also down-regulated in dedifferentiated hfRPE cells. MITF knockdown decreased miR-204/211 expression and caused hfRPE dedifferentiation. (PMID:22523078)
• These findings support the hypothesis that miR-204 plays critical roles in Malignant peripheral nerve sheath tumor development (PMID:22718995)
• miRNA-204 is among the regulators that drive hCMPC proliferation and differentiation, and miRNA-204 might be used to influence cell fate. (PMID:22982025)
• Downregulation of miR-204 releases aberrant expression of Bcl-2 protein in gastric tumor. (PMID:23152059)
• our findings reveal miR-204 as a pivotal regulator of the development of stem cell-like phenotypes and cell motility in malignant glioma cells. (PMID:23204229)
• Microdeletion of genomic loci containing miR-204 is directly linked with the deregulation of key oncogenic pathways that provide crucial stimulus for tumor growth and metastasis. (PMID:23285024)
• The data suggest existence of a complex regulatory pathway in the trabecular meshwork part of which includes interactions between FOXC1, miR-204, MEIS2, and ITGbeta1. (PMID:23541832)
• the microRNA miR-204 promotes both mesenchymal neural crest and lens cell migration and elongation by the direct targeting of the Ankrd13A gene. (PMID:23620728)
• These data demonstrate that miR-204 plays an important role in regulating metastasis of gastric cancer, which is involved in post-transcriptional repression of SIRT1. (PMID:23768087)
• Triptolide mediated miR-204 increase causes pancreatic cancer cell death via loss of Mcl-1. (PMID:24025188)
• Down-regulation of miR-204 is associated with metastasis of intrahepatic cholangiocarcinoma.MiR-204 inhibits epithelial to mesenchymal transition by targeting Slug protein in intrahepatic cholangiocarcinoma cells. (PMID:24280681)
• Study uncovers a new regulatory loop involving TrkB/miR-204-5p that is critical to the tumorigenesis of endometrial carcinoma. (PMID:24321270)
• The human cdc42 gene is a direct target of miR-204. (PMID:24613926)
• statistically significantly lower expression of miR-204 in all nephroblastomas investigated might point to an involvement of miR-204 in the regulation of MEIS1 in nephroblastomas (PMID:24617557)
• MiR-204-3p acts on its potential target gene, FN1, and inhibits its expression, thus blocking the adhesion function of FN1 in promoting the growth of endothelial cells from hepatocellular carcinomas. (PMID:24833879)
• miR-204 may be a potential diagnostic and prognostic biomarker of breast cancer. (PMID:25031750)
• MiR-204 promotes apoptosis in oxidative stress-induced rat Schwann cells by suppressing neuritin expression (PMID:25036738)
• MicroRNA-204, a direct negative regulator of ezrin gene expression, inhibits glioma cell migration and invasion. (PMID:25055875)
• miR-204 binds to the SIX1 3’-UTR and regulates invasion in vitro. miR-204 expression was decreased in lung cancer tissues. (PMID:25157435)
• miR-204-5p levels in cancer patients are higher than the levels of the healthy population and this situation is not related to clinicopathological parameters or survivals. (PMID:25209181)
• miR-204-5p acts as a tumor suppressor in colorectal cancer through inhibiting RAB22A and reveal RAB22A to be a new oncogene and prognostic factor for colorectal cancer. (PMID:25294901)
• High MIR204 expression is associated with high grade-invasive pancreatic cancer. (PMID:25304377)
• findings suggest that Tra2beta regulates apoptosis by modulating Bcl-2 expression through its competition with miR-204. This novel function may have a crucial role in tumor growth. (PMID:25342468)
• MiR-205 is developmentally regulated in the hippocampus and may contribute to the molecular mechanisms underlying the pathogenesis of mesial temporal lobe epilepsy and hippocampal sclerosis. (PMID:25410734)
• The miR-204 acts as a tumour suppressor by inhibiting NUAK1 expression in NSCLC. (PMID:25412236)
• miR-204-5p acts as a tumor suppressor in gastric cancer through inhibiting USP47 and RAB22A. (PMID:25429829)
• The von Hippel-Lindau tumor suppressor (VHL) represses TRPM3 directly through miR-204 and indirectly through another miR-204 target, Caveolin 1. (PMID:25517751)
• miR-204-5p suppresses IGFBP5 expression by direct binding to the 3’ untranslated region. (PMID:25603050)
• Results found dualistic miR-204 effects, either acting as a tumor suppressor on c-MYB, or as an oncomiR on ETS1. RUNX2 and ETS1 regulation by miR-204 was ERG fusion dependent, demonstrating regulatory circuitry disruption in advanced metastatic models. (PMID:25630658)
• MiR204 could bind the 3’untranslated region of signal transducer activator of transcription 5 (STAT5), a transcription factor that promotes Bcell lymphoma oncogenesis. (PMID:25651400)
• MiR-204 inhibits hepatocellular carcinoma cell proliferation and induce apoptosis by down-regulating the expressions of Bcl-2 and Sirt1. (PMID:25652855)
• miR-204 is downregulated under hypoxic conditions, which leads to activation of STAT3 pathway promoting proliferation and Pulmonary arterial hypertension progression. (PMID:25660363)
• Data show that the AR-miR-204-XRN1-miR-34a positive feedback loop and a dual function of miR-204/XRN1 axis in prostate cancer. (PMID:25797256)
• data suggest that miR-204-5p regulates adipogenesis by controlling DVL3 expression and subsequently inhibiting the activation of the Wnt/beta-catenin signaling pathway. (PMID:25847080)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir204-1	ENSDARG00000081105
mus_musculus	Mir204	ENSMUSG00000065507
rattus_norvegicus	Mir204	ENSRNOG00000035472

Paralogs (1): MIR211 (ENSG00000207702)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.