MIR205

Summary

MIR205 (microRNA 205, HGNC:31583) is a microRNA gene on chromosome 1q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406988 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31583
Approved symbol	MIR205
Name	microRNA 205
Location	1q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-205
Ensembl gene	ENSG00000284485
Ensembl biotype	miRNA
OMIM	613147
Entrez	406988
RNAcentral	URS0000016914 — miRNA, 110 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384891

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384891 — 1 exons

Exon	Start	End
ENSE00001499898	209432133	209432242

Expression profiles

Bgee: expression breadth broad, 71 present calls, max score 98.13.

Top tissues by expression

71 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	98.13	gold quality
esophagus mucosa	UBERON:0002469	93.21	gold quality
esophagus	UBERON:0001043	91.94	gold quality
skin of leg	UBERON:0001511	91.56	gold quality
zone of skin	UBERON:0000014	91.19	gold quality
skin of abdomen	UBERON:0001416	90.50	gold quality
ectocervix	UBERON:0012249	89.03	gold quality
vagina	UBERON:0000996	88.43	gold quality
thoracic mammary gland	UBERON:0005200	85.17	gold quality
epididymis	UBERON:0001301	84.48	gold quality
prostate gland	UBERON:0002367	83.67	gold quality
lower esophagus mucosa	UBERON:0035834	83.30	gold quality
endocervix	UBERON:0000458	82.02	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	79.85	gold quality
saliva-secreting gland	UBERON:0001044	78.20	gold quality
tonsil	UBERON:0002372	78.19	gold quality
urinary bladder	UBERON:0001255	78.04	gold quality
minor salivary gland	UBERON:0001830	77.88	gold quality
gastrocnemius	UBERON:0001388	76.32	gold quality
subcutaneous adipose tissue	UBERON:0002190	75.73	gold quality
islet of Langerhans	UBERON:0000006	74.36	gold quality
blood	UBERON:0000178	73.65	gold quality
placenta	UBERON:0001987	73.05	gold quality
lower esophagus muscularis layer	UBERON:0035833	72.89	gold quality
right lobe of liver	UBERON:0001114	72.83	gold quality
left ovary	UBERON:0002119	72.41	gold quality
right atrium auricular region	UBERON:0006631	71.33	gold quality
ovary	UBERON:0000992	70.86	gold quality
heart left ventricle	UBERON:0002084	70.83	gold quality
body of pancreas	UBERON:0001150	70.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.02

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): TWIST1

Literature-anchored findings (GeneRIF, showing 40)

• detected overexpression of mature miR-21 in 25 of the 48 NSCLC paired specimens and overexpression of miR-205 in 31 (PMID:18719201)
• the corneal epithelial-specific miR-184 can interfere with the ability of miR-205 to suppress SHIP2 levels (PMID:19033458)
• CK-8 and miR-143 expression were significantly higher in Barrett’s mucosa, before and after APC, whereas miRNA-205 and CK-14 expression was significantly lower in Barrett’s mucosa compared to all categories of squamous mucosa. (PMID:19190970)
• The microRNA-205-mediated suppression is likely through the direct interaction with the putative microRNA-205 binding site in the 3’-untranslated region of receptor, erbB-3 and Vascular Endothelial Growth Factor A. (PMID:19238171)
• miR-205 exerts a tumor-suppressive effect in human prostate by counteracting epithelial-to-mesenchymal transition and reducing cell migration/invasion, at least in part through the down-regulation of protein kinase Cepsilon. (PMID:19244118)
• These results, for the first time, demonstrate that expression of human LRP1 is regulated in part by MIR205, leading to decreased tumor cell migration. (PMID:19665999)
• Ectopic expression of miR-205 significantly inhibits cell proliferation and anchorage-independent growth as well as cell invasion–REVIEW (PMID:19839716)
• High miR-205 is associated with squamous cell carcinoma of head and neck and the esophagus. (PMID:20428818)
• The role that miR-205 plays in tumor formation and metastasis is likely context-dependent. (PMID:20436283)
• down-regulation of miR-205 resulted in an increase in Rho-ROCKI activity, phosphorylation of the actin severing protein cofilin, and a corresponding diminution of filamentous actin (PMID:20530248)
• expressed altered in esophageal squamous cell carcinoma (PMID:20588024)
• We found a significant down-regulation of the miR-200 family and miR-205, loss of desmosomal cadherins, and an altered expression of classic cadherins in spindle cell carcinoma (PMID:21237487)
• The relative quantification of miR-205 and miR-21 seems to be a promising diagnostic tool for lung neoplasms. (PMID:21263248)
• Overexpression of miR-205 in A498 cells resulted in induction of cell-cycle arrest and apoptosis, as indicated by decreased levels of cyclin D1 and c-Myc, suppressed cell proliferation, colony formation, migration, and invasion in renal cancer cells. (PMID:21330408)
• EMT was epigenetically driven by chromatin remodeling through H3K27me3 enrichment and later by ensuing DNA methylation to sustain silencing of tumor-suppressive microRNAs (miRNA), miR-200b, miR-200c, and miR-205. (PMID:21363915)
• The downregulation of miR-205 and miR-31 has an important role in apoptosis resistance in advanced prostate cancer. (PMID:21368878)
• serum and urinary levels lower in systemic lupus erythematosus patients than in controls (PMID:21372198)
• These results imply that miR-205 is an ESCC-specific miR that exerts tumor-suppressive activities with epithelial mesenchymal transition inhibition by targeting ZEB2. (PMID:21426561)
• The high expression of mature mature MIR205 was associated with lymph node positivity in ESCC patients (PMID:21453382)
• miRNA-205 suppresses melanoma cell proliferation and induces senescence via regulation of E2F1 protein (PMID:21454583)
• These results suggest that down-regulation of miR-205 in erbB2-overexpressing breast epithelial cells is essential for erbB2-induced tumorigenesis. (PMID:21787752)
• miRNA-205 is a glioma-specific tumor suppressor which targets VEGF-A. (PMID:22159356)
• identified a series of differentially expressed miRNAs that could be useful as diagnostic or prognostic markers for melanoma and have shown that three miRNAs (namely miR-200c, miR-205 and miR-211) act as tumour suppressors (PMID:22223089)
• miR-205 is associated with breast tumours of ductal morphology and is of significant positive prognostic value within these tumours. We propose that the expression of miR-205 may contribute to ductal tumour morphology. (PMID:22294324)
• Metformin-induced stress-induced cellular senescence relates to upregulation of the microRNA-200 family and miR-205. (PMID:22356767)
• Data conclude that miR-205 contributes to radioresistance of nasopharyngeal carcinoma by directly targeting PTEN. (PMID:22374676)
• microRNAs that jointly act as tumor suppressors in prostate carcinoma (PMID:22391564)
• miR-205 holds a unique potential as a prognostic biomarker in endometrial cancer. (PMID:22514717)
• miR-205 demonstrated a statistically significant, progressive diminution in expression from nevi to primary melanomas to metastatic melanomas. (PMID:22525428)
• The miR-205 participates in a network involving DeltaNp63alpha, which is essential for maintenance of the BM in prostate epithelium. (PMID:22555458)
• miR-205, oncosuppressive microRNA lost in breast cancer, is directly transactivated by oncosuppressor p53. (PMID:22578566)
• expression of MiR-21, MiR-205, and MiR-342 was analyzed in ER-positive and/or PR-positive group (group I); HER2-positive group (group II); and ER/PR/HER2- negative (group III) breast cancer; expression of miR-21 was similar in all 3 groups; miR-205 and miR-342 expression were down regulated in group III (PMID:22631664)
• our results suggest that miR-21, miR-205, miR-30d, and miR-24 may serve as potential novel non-invasive biomarkers for diagnosis of lung cancer (PMID:22782668)
• miR-205 serves a protective role against both oxidative and endoplasmic reticulum stresses via the suppression of EGLN2 and subsequent decrease in intracellular reactive oxygen species. (PMID:22859986)
• MiR-205 is an epigenetically regulated tumor suppressor that targets MED1. (PMID:22869146)
• E2F1 and miR-205 are crucial regulators of genes associated with chemoresistance in aggressive tumors. (PMID:22871739)
• Low levels of melanoma cell miR-205 expression as quantified by ISH show worse outcome, supporting the role of miR-205 as a tumor suppressor miRNA. (PMID:22890556)
• p63/miR-205 may have a role in prostate cancer metastasis (PMID:22949650)
• Upregulation of MIR205 is associated with recurrent endometrial carcinoma. (PMID:22987275)
• A significantly reduced expression of microRNA (miR)-200c and miR-205 in docetaxel-resistant cells, is reported. (PMID:23041061)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-205	ENSDARG00000081646
mus_musculus	Mir205	ENSMUSG00000065533

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.