MIR2052

Summary

MIR2052 (microRNA 2052, HGNC:37068) is a microRNA gene on chromosome 8q21.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302260 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37068
Approved symbol	MIR2052
Name	microRNA 2052
Location	8q21.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2052
Ensembl gene	ENSG00000283188
Ensembl biotype	miRNA
Entrez	100302260
RNAcentral	URS000075A536 — ncRNA, 55 nt, 26 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636055

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636055 — 1 exons

Exon	Start	End
ENSE00003793071	74705693	74705747

Expression profiles

Bgee: expression breadth broad, 51 present calls, max score 82.05.

Top tissues by expression

51 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	82.05	gold quality
prostate gland	UBERON:0002367	79.96	gold quality
calcaneal tendon	UBERON:0003701	78.32	gold quality
kidney	UBERON:0002113	78.30	gold quality
lung	UBERON:0002048	73.58	gold quality
islet of Langerhans	UBERON:0000006	73.03	gold quality
ascending aorta	UBERON:0001496	72.32	gold quality
gastrocnemius	UBERON:0001388	72.17	gold quality
adult mammalian kidney	UBERON:0000082	71.60	gold quality
tonsil	UBERON:0002372	70.88	gold quality
heart	UBERON:0000948	70.41	gold quality
right atrium auricular region	UBERON:0006631	69.63	gold quality
heart left ventricle	UBERON:0002084	69.62	gold quality
putamen	UBERON:0001874	69.57	gold quality
ovary	UBERON:0000992	69.46	gold quality
left adrenal gland cortex	UBERON:0035825	69.43	gold quality
endometrium	UBERON:0001295	69.25	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.89	gold quality
left ovary	UBERON:0002119	68.72	gold quality
anterior cingulate cortex	UBERON:0009835	68.69	gold quality
body of pancreas	UBERON:0001150	68.65	gold quality
corpus callosum	UBERON:0002336	68.33	gold quality
tibial artery	UBERON:0007610	68.06	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.04	gold quality
esophagus mucosa	UBERON:0002469	67.94	gold quality
skin of leg	UBERON:0001511	67.72	gold quality
stomach	UBERON:0000945	67.60	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.14	gold quality
colon	UBERON:0001155	67.01	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.14

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.