MIR2052HG

Summary

MIR2052HG (MIR2052 host gene, HGNC:51555) is a long non-coding RNA gene on chromosome 8q21.11-q21.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51555
Approved symbol	MIR2052HG
Name	MIR2052 host gene
Location	8q21.11-q21.13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000254349
Ensembl biotype	lncRNA
Entrez	441355
RNAcentral	URS000075D880 — lncRNA, 2125 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 24 lncRNA

ENST00000518190, ENST00000521762, ENST00000523118, ENST00000523442, ENST00000666796, ENST00000718005, ENST00000718006, ENST00000718007, ENST00000718008, ENST00000718009, ENST00000718010, ENST00000718011, ENST00000718032, ENST00000718033, ENST00000718034, ENST00000718035, ENST00000718142, ENST00000718143, ENST00000718144, ENST00000718145, ENST00000718146, ENST00000718147, ENST00000718148, ENST00000809989

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000518190 — 6 exons

Exon	Start	End
ENSE00002098676	74615076	74615139
ENSE00002110660	74599775	74599908
ENSE00002113509	74625249	74625341
ENSE00002121152	74703606	74703679
ENSE00003755723	74702379	74702456
ENSE00003758440	74612853	74612940

Expression profiles

Bgee: expression breadth ubiquitous, 135 present calls, max score 85.34.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0236 / max 2.3026, expressed in 12 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
89409	0.0236	12

Top tissues by expression

222 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.34	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.70	gold quality
sural nerve	UBERON:0015488	80.42	gold quality
buccal mucosa cell	CL:0002336	64.69	silver quality
hindlimb stylopod muscle	UBERON:0004252	60.68	gold quality
ventricular zone	UBERON:0003053	58.16	silver quality
left uterine tube	UBERON:0001303	58.07	gold quality
calcaneal tendon	UBERON:0003701	56.79	gold quality
monocyte	CL:0000576	56.49	gold quality
vermiform appendix	UBERON:0001154	56.38	gold quality
skin of hip	UBERON:0001554	55.96	silver quality
islet of Langerhans	UBERON:0000006	55.85	gold quality
gall bladder	UBERON:0002110	54.45	gold quality
corpus callosum	UBERON:0002336	53.94	gold quality
upper leg skin	UBERON:0004262	53.38	silver quality
muscle of leg	UBERON:0001383	53.34	gold quality
gastrocnemius	UBERON:0001388	52.91	gold quality
adrenal tissue	UBERON:0018303	51.97	gold quality
prefrontal cortex	UBERON:0000451	51.32	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	51.12	gold quality
pancreas	UBERON:0001264	50.67	gold quality
blood	UBERON:0000178	49.81	silver quality
caecum	UBERON:0001153	48.77	gold quality
granulocyte	CL:0000094	48.50	silver quality
smooth muscle tissue	UBERON:0001135	48.50	gold quality
right lobe of liver	UBERON:0001114	46.41	silver quality
body of pancreas	UBERON:0001150	46.37	silver quality
popliteal artery	UBERON:0002250	46.31	gold quality
tibial artery	UBERON:0007610	46.26	gold quality
vagina	UBERON:0000996	46.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.92

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Our findings support a model in which the MIR2052HG regulates LMTK3 via EGR1, and LMTK3 regulates ERalpha stability via the PKC/MEK/ERK/RSK1 axis. These results reveal a direct role of MIR2052HG in LMTK3 regulation and raise the possibilities of targeting MIR2052HG or LMTK3 in ERalpha-positive breast cancer. (PMID:30944027)
• Polymorphisms in lncRNA MIR2052HG and susceptibility to breast cancer in Chinese population. (PMID:34762068)
• Association between the rs3802201 polymorphism of the lncRNA MIR2052HG gene and the risk of recurrent miscarriage in a Southern Chinese population. (PMID:34910326)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.