MIR2053

Summary

MIR2053 (microRNA 2053, HGNC:37069) is a microRNA gene on chromosome 8q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302225 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37069
Approved symbol	MIR2053
Name	microRNA 2053
Location	8q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2053
Ensembl gene	ENSG00000238399
Ensembl biotype	miRNA
Entrez	100302225
RNAcentral	URS000075BFA3 — miRNA, 91 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000459295

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000459295 — 1 exons

Exon	Start	End
ENSE00001807816	112643493	112643583

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 71.55.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	71.55	gold quality
gastrocnemius	UBERON:0001388	71.47	gold quality
stomach	UBERON:0000945	70.37	gold quality
intestine	UBERON:0000160	70.35	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.99	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.36	gold quality
anterior cingulate cortex	UBERON:0009835	64.68	gold quality
corpus callosum	UBERON:0002336	64.02	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.84	gold quality
nucleus accumbens	UBERON:0001882	63.75	gold quality
substantia nigra	UBERON:0002038	63.08	gold quality
caudate nucleus	UBERON:0001873	62.31	gold quality
hypothalamus	UBERON:0001898	59.90	gold quality
right frontal lobe	UBERON:0002810	59.48	gold quality
vagina	UBERON:0000996	59.01	gold quality
colon	UBERON:0001155	48.32	gold quality
left testis	UBERON:0004533	41.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• The expression of serum DRAM1 messenger RNA (mRNA), ARSA mRNA, hsa-miR-2053 and lncRNA-RP1-86D1.3 were positive in 78.3%, 90%, 85%, and 83.3% of MPM patients, respectively. (PMID:30362153)
• Down-Regulation of miR-2053 Inhibits the Development and Progression of Esophageal Carcinoma by Targeting Fyn-Related Kinase (FRK). (PMID:31894485)
• MicroRNA-2053 involves in the progression of esophageal cancer by targeting KIF3C. (PMID:34057012)
• A variant rs6214 within IGF-1 confers risk for ulcerative colitis in Chinese Han populations. (PMID:36520299)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.