MIR2054

Summary

MIR2054 (microRNA 2054, HGNC:37070) is a microRNA gene on chromosome 4q28.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302267 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37070
Approved symbol	MIR2054
Name	microRNA 2054
Location	4q28.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2054
Ensembl gene	ENSG00000283550
Ensembl biotype	miRNA
Entrez	100302267
RNAcentral	URS000075C28D — ncRNA, 49 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636770

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636770 — 1 exons

Exon	Start	End
ENSE00003796756	125507259	125507307

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 75.82.

Top tissues by expression

5 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	75.82	gold quality
calcaneal tendon	UBERON:0003701	71.09	gold quality
right frontal lobe	UBERON:0002810	68.62	gold quality
lung	UBERON:0002048	67.50	gold quality
left testis	UBERON:0004533	45.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.