MIR205HG

Summary

MIR205HG (MIR205 host gene, HGNC:43562) is a long non-coding RNA gene on chromosome 1q32.2.

Predicted to be involved in several processes, including hormone biosynthetic process; prolactin metabolic process; and regulation of DNA-binding transcription factor activity.

Source: NCBI Gene 642587 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43562
Approved symbol	MIR205HG
Name	MIR205 host gene
Location	1q32.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	LEADR, miPEP205, LINC00510
Ensembl gene	ENSG00000230937
Ensembl biotype	lncRNA
Entrez	642587
RNAcentral	URS0000ABD848 — lncRNA, 940 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 61 — 57 lncRNA, 4 retained_intron

ENST00000366437, ENST00000419143, ENST00000429156, ENST00000431096, ENST00000433108, ENST00000440276, ENST00000444286, ENST00000451937, ENST00000458250, ENST00000603283, ENST00000657184, ENST00000660261, ENST00000660782, ENST00000667171, ENST00000670788, ENST00000691439, ENST00000692388, ENST00000830927, ENST00000830928, ENST00000830929, ENST00000830930, ENST00000830931, ENST00000830932, ENST00000830933, ENST00000830934, ENST00000830935, ENST00000830936, ENST00000830937, ENST00000830938, ENST00000830939, ENST00000830940, ENST00000830941, ENST00000830942, ENST00000830943, ENST00000830944, ENST00000830945, ENST00000830946, ENST00000830947, ENST00000830948, ENST00000830949, ENST00000830950, ENST00000830951, ENST00000830952, ENST00000830953, ENST00000830954, ENST00000830955, ENST00000830956, ENST00000830957, ENST00000830958, ENST00000830959, ENST00000830960, ENST00000830961, ENST00000830962, ENST00000830963, ENST00000830964, ENST00000830965, ENST00000830966, ENST00000830967, ENST00000830968, ENST00000830969, ENST00000830970

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000366437 — 4 exons

Exon	Start	End
ENSE00001599565	209432204	209432549
ENSE00003736666	209429181	209429408
ENSE00003741000	209430425	209430476
ENSE00004245956	209428818	209429088

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 99.15.

FANTOM5 (CAGE): breadth broad, TPM avg 38.8292 / max 4501.5626, expressed in 423 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
8299	37.9555	420
8306	0.4347	109
8301	0.1073	57
8302	0.1016	50
8300	0.0829	41
8304	0.0465	21
201935	0.0281	13
8308	0.0281	15
8303	0.0261	15
8307	0.0184	5

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	99.15	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	98.62	gold quality
skin of abdomen	UBERON:0001416	98.31	gold quality
skin of leg	UBERON:0001511	97.86	gold quality
esophagus mucosa	UBERON:0002469	97.67	gold quality
zone of skin	UBERON:0000014	95.44	gold quality
minor salivary gland	UBERON:0001830	92.95	gold quality
mouth mucosa	UBERON:0003729	91.73	gold quality
gingival epithelium	UBERON:0001949	89.48	silver quality
vagina	UBERON:0000996	89.44	gold quality
saliva-secreting gland	UBERON:0001044	88.56	gold quality
gingiva	UBERON:0001828	88.29	silver quality
prostate gland	UBERON:0002367	86.38	gold quality
upper leg skin	UBERON:0004262	84.04	gold quality
tonsil	UBERON:0002372	82.97	gold quality
skin of hip	UBERON:0001554	82.70	gold quality
sural nerve	UBERON:0015488	82.53	gold quality
mammary duct	UBERON:0001765	82.27	silver quality
bone marrow cell	CL:0002092	81.86	gold quality
oral cavity	UBERON:0000167	81.76	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.15	silver quality
esophagus squamous epithelium	UBERON:0006920	80.00	silver quality
urinary bladder	UBERON:0001255	79.81	gold quality
mammalian vulva	UBERON:0000997	78.82	silver quality
esophagus	UBERON:0001043	78.09	gold quality
corpus epididymis	UBERON:0004359	77.59	silver quality
nasal cavity mucosa	UBERON:0001826	76.35	gold quality
mammary gland	UBERON:0001911	74.16	gold quality
thoracic mammary gland	UBERON:0005200	74.05	gold quality
epithelium of nasopharynx	UBERON:0001951	73.06	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-126	yes	1008.91
E-MTAB-10596	no	2102.65
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Our findings provide insights into simultaneous regulatory role of miR-205 in the pathogenesis of anaplastic thyroid carcinoma by suppressing both angiogenesis and epithelial-to-mesenchymal transition. (PMID:29317480)
• These results demonstrated that MIR205HG could serve as a ceRNA in cervical cancer progression by modulating miR-122-5p/FOXP2 axis and exert a pro-tumorigenesis function. (PMID:31023531)
• High MIR205HG expression is associated with progression of cervical cancer. (PMID:31655037)
• MIR205HG facilitates carcinogenesis of lung squamous cell carcinoma in vitro revealed by long noncoding RNA profiling. (PMID:32188965)
• LncRNA MIR205HG regulates melanomagenesis via the miR-299-3p/VEGFA axis. (PMID:33535182)
• LncRNA miR205HG hinders HNRNPA0 translation: anti-oncogenic effects in esophageal carcinoma. (PMID:34821009)
• LncRNA MIR205HG accelerates cell proliferation, migration and invasion in hepatoblastoma through the activation of MAPK signaling pathway and PI3K/AKT signaling pathway. (PMID:34996511)
• The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis. (PMID:38252669)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.