MIR208A

Summary

MIR208A (microRNA 208a, HGNC:31585) is a microRNA gene on chromosome 14q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406990 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31585
Approved symbol	MIR208A
Name	microRNA 208a
Location	14q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-208, hsa-mir-208a
Ensembl gene	ENSG00000199157
Ensembl biotype	miRNA
OMIM	611116
Entrez	406990
RNAcentral	URS0000759A9B — miRNA, 71 nt, 14 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362287

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362287 — 1 exons

Exon	Start	End
ENSE00001437050	23388596	23388666

Expression profiles

Bgee: expression breadth broad, 37 present calls, max score 90.66.

Top tissues by expression

37 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right atrium auricular region	UBERON:0006631	90.66	gold quality
skeletal muscle tissue	UBERON:0001134	89.41	gold quality
heart	UBERON:0000948	85.33	gold quality
heart left ventricle	UBERON:0002084	81.24	gold quality
muscle of leg	UBERON:0001383	76.60	gold quality
apex of heart	UBERON:0002098	75.47	gold quality
gastrocnemius	UBERON:0001388	75.38	gold quality
blood	UBERON:0000178	74.60	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.88	gold quality
ascending aorta	UBERON:0001496	68.64	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.71	gold quality
left adrenal gland cortex	UBERON:0035825	67.70	gold quality
left adrenal gland	UBERON:0001234	67.58	gold quality
body of pancreas	UBERON:0001150	67.45	gold quality
right frontal lobe	UBERON:0002810	66.84	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.84	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.64	gold quality
body of stomach	UBERON:0001161	66.46	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.08	gold quality
skin of abdomen	UBERON:0001416	64.34	gold quality
nucleus accumbens	UBERON:0001882	64.02	gold quality
hypothalamus	UBERON:0001898	63.93	gold quality
left lobe of thyroid gland	UBERON:0001120	63.67	gold quality
prostate gland	UBERON:0002367	63.56	gold quality
putamen	UBERON:0001874	63.36	gold quality
substantia nigra	UBERON:0002038	62.96	gold quality
skin of leg	UBERON:0001511	62.73	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.63	gold quality
amygdala	UBERON:0001876	62.52	gold quality
left uterine tube	UBERON:0001303	62.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 37)

• miR-208 was upregulated, whereas miR-1 and miR-133a were downregulated in MI compared to healthy adult and fetal hearts. All four tested miRNAs were downregulated in fetal hearts compared to healthy adult hearts. (PMID:20029200)
• The researchers found an association between myocardial miR-208 expression and myosin heavy chain expression and adverse outcomes in patients with dilated cardiomyopathy (PMID:20447577)
• Studies indicate that the plasma miR-133 and miR-328 are increased 11- to 16-fold in patients with acute myocardial Infarction. (PMID:22713968)
• Studies indicate that miR-208a and miR-208b are involved in the regulation of the myosin heavy chain isoform switch during development and in pathophysiological conditions within the heart. (PMID:23121236)
• In stable coronary artery disease and acute myocardial infarction, in comparison to control group, the expression level of miR-208a did not show significant difference (PMID:24253456)
• Serum microRNAs were identified as cardiovascular risk factors in dyslipidemia. (PMID:24461990)
• The miR-208 induces epithelial to mesenchymal transition of pancreatic cancer cell line BxPC3 by activating AKT/GSK-3beta/snail signaling pathway. (PMID:24604208)
• results suggest that miR-208 represents a potential onco-miR and participates in ESCC carcinogenesis by suppressing SOX6 expression (PMID:25023649)
• results also suggest the involvement of miR-208a and miR-1 in the proliferation as well as anti-proliferative and anti-apoptotic roles of miR-133a/b. (PMID:25125495)
• High MIR208 expression is associated with atypical coronary artery disease. (PMID:25198728)
• The miR-208 family is closely associated with the development of cardiac diseases, such as myocardial hypertrophy, cardiac fibrosis, myocardial infarction, arrhythmia, and heart failure. [Review] (PMID:25840809)
• These findings suggested that miR-208-3p up-regulation is associated with hepatocellular carcinoma cell progression. (PMID:26169693)
• plasma miR-1, miR-208 and miR-499 were demonstrated to be potential biomarkers for the prediction of acute myocardial infarction (PMID:26526403)
• Plasma miRNA-208a is an interesting and promising candidate for a new biomarker released early after onset of myocardial infarction. (PMID:26528525)
• Study provides evidence that miR-208a can affect the proliferation and radio-sensitivity of human lung cancer cells by targeting p21. (PMID:26754670)
• Atrial and ventricular tissues display characteristic miR-208 expression signatures under physiological conditions. (PMID:26974694)
• We demonstrated that miR-208a-3p suppressed apoptosis in gastric cancer cells by targeting PDCD4. (PMID:27634902)
• Downregulation of hsa-miR-208a-3p and hsa-miR-1207-5p may be involved in the occurrence of medulloblastoma (PMID:28481393)
• The expression of circulating microRNA-208a is positively correlated with the severity of coronary heart disease. (PMID:28554251)
• MiR-208a enhances cell proliferation and invasion of gastric cancer by targeting SFRP1 and negatively regulating MEG3 (PMID:29886152)
• Early modulation of miR-208a in the diabetic heart induces alterations in the downstream signaling pathway leading to cardiac remodeling. (PMID:30696455)
• Our data suggest that miR-208-5p/DAAM1 axis participates in ovarian cancer migration and invasion. (PMID:31104928)
• the present study is the first to provide evidence that miR208a exerts oncogenic functions in the carcinogenesis and progression of nonsmall cell lung cancer by directly targeting SRCIN1 and regulating the ERK pathway. (PMID:31432113)
• Bone marrow-derived mesenchymal stem cell-derived exosomal microRNA-208a promotes osteosarcoma cell proliferation, migration, and invasion. (PMID:31637737)
• Preoperative miRNA-208a as a Predictor of Postoperative Complications in Children with Congenital Heart Disease Undergoing Heart Surgery. (PMID:31732917)
• Data found that increased plasma levels of miR-208b and miR-499 were significantly associated with coronary artery disease (CAD) severity. Plasma miR-208b and miR-499 can act as potential biomarkers for estimating the severity of CAD. (PMID:31885748)
• MicroRNA-208a-3p is upregulated in premenopausal osteoporosis patients and upregulated in postmenopausal osteoporosis patients. (PMID:32151564)
• MYH7B variants cause hypertrophic cardiomyopathy by activating the CaMK-signaling pathway. (PMID:32207065)
• MicroRNA-208a: a Good Diagnostic Marker and a Predictor of no-Reflow in STEMI Patients Undergoing Primary Percutaneuos Coronary Intervention. (PMID:32458401)
• Diagnostic value of circulating microRNA-208a in differentiation of preserved from reduced ejection fraction heart failure. (PMID:32711895)
• Emerging roles of microRNA-208a in cardiology and reverse cardio-oncology. (PMID:33533026)
• Cyclic stretching boosts microRNA-499 to regulate Bcl-2 via microRNA-208a in atrial fibroblasts. (PMID:33605072)
• Myocardial Infarction-Associated Extracellular Vesicle-Delivered miR-208b Affects the Growth of Human Umbilical Vein Endothelial Cells via Regulating CDKN1A. (PMID:34195287)
• MicroRNAs in Fetal Umbilical Cord Blood as a Prenatal Screening Tool for Congenital Heart Disease. (PMID:34686514)
• MiR 208a Regulates Mitochondrial Biogenesis in Metabolically Challenged Cardiomyocytes. (PMID:34831374)
• Diagnostic and Prognostic Significance of microRNA-208a in Acute Myocardial Infarction. (PMID:35607440)
• miR-208a-3p regulated by circUQCRC2 suppresses ischemia/reperfusion-induced acute kidney injury by inhibiting CELF2-mediated tubular epithelial cell apoptosis, inflammation and ferroptosis. (PMID:38664873)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir208a	ENSMUSG00000065432
rattus_norvegicus	Mir3546	ENSRNOG00000035583

Paralogs (1): MIR208B (ENSG00000215991)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.