MIR208B

Summary

MIR208B (microRNA 208b, HGNC:33669) is a microRNA gene on chromosome 14q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126336 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33669
Approved symbol	MIR208B
Name	microRNA 208b
Location	14q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-208b
Ensembl gene	ENSG00000215991
Ensembl biotype	miRNA
OMIM	613613
Entrez	100126336
RNAcentral	URS000075DEE7 — miRNA, 77 nt, 27 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401172

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401172 — 1 exons

Exon	Start	End
ENSE00001546516	23417987	23418063

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 95.33.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	95.33	gold quality
apex of heart	UBERON:0002098	95.03	gold quality
pancreas	UBERON:0001264	92.53	gold quality
heart left ventricle	UBERON:0002084	90.58	gold quality
skeletal muscle tissue	UBERON:0001134	90.01	gold quality
heart	UBERON:0000948	89.10	gold quality
right atrium auricular region	UBERON:0006631	87.06	gold quality
muscle of leg	UBERON:0001383	82.49	gold quality
gastrocnemius	UBERON:0001388	80.08	gold quality
descending thoracic aorta	UBERON:0002345	77.06	gold quality
caudate nucleus	UBERON:0001873	75.79	gold quality
putamen	UBERON:0001874	75.27	gold quality
islet of Langerhans	UBERON:0000006	73.33	gold quality
blood	UBERON:0000178	72.57	gold quality
right adrenal gland	UBERON:0001233	71.66	gold quality
minor salivary gland	UBERON:0001830	71.43	gold quality
stomach	UBERON:0000945	71.08	gold quality
body of stomach	UBERON:0001161	70.32	gold quality
ascending aorta	UBERON:0001496	69.64	gold quality
nucleus accumbens	UBERON:0001882	68.91	gold quality
right frontal lobe	UBERON:0002810	68.65	gold quality
substantia nigra	UBERON:0002038	68.39	gold quality
pituitary gland	UBERON:0000007	68.37	gold quality
left adrenal gland cortex	UBERON:0035825	67.73	gold quality
adenohypophysis	UBERON:0002196	67.31	gold quality
left adrenal gland	UBERON:0001234	67.07	gold quality
right lobe of liver	UBERON:0001114	66.86	gold quality
transverse colon	UBERON:0001157	66.49	gold quality
skin of leg	UBERON:0001511	66.39	gold quality
tibial artery	UBERON:0007610	66.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ARID3B

Literature-anchored findings (GeneRIF, showing 21)

• Cardiac damage initiates the detectable release of cardiomyocyte-specific microRNAs-208b and -499 into the circulation (PMID:20921333)
• Report increased serum miR-208b in the blood of myocardial infarction patients and establish association of increased miRNA levels with reduced systolic function after MI and risk of death or heart failure. (PMID:23448306)
• Circulating miR208b and miR499 are not predictive of mortality in acute myocardial infarct. (PMID:23871635)
• Data indicate that hepatitis C virus (HCV) was able to induce two microRNAs (miRNAs), miR-208b and miR-499a-5p, that target the interferon-lambda3 (IFN-lambda3) 3’ untranslated region (3’ UTR). (PMID:24241692)
• Data indicate that the relative expression of microRNAs miR-1, miR-208b, and miR-499a in the acute myocardial infarction (AMI) samples was 0.73-fold (a 1.4-fold decrease), 1.2-fold, and 0.48-fold (a 2.1-fold decrease), respectively. (PMID:26046358)
• MIR208B redundantly programs skeletal muscle fibers to a slow (type1)phenotype at the expense of the fast phenotype. (PMID:26342566)
• Mir-208b was increased in patients with acute myocardial infarction. (PMID:26712201)
• miRNA-208b and miRNA-133a show distinct profiling in peripheral blood cells isolated from untreated patients with recently diagnosed essential hypertension. Their gene expression levels reveal a strong correlation with urinary albumin excretion levels. (PMID:26984682)
• These findings clearly pointed to CAF-specific upregulated miR-208b as an important mediator in Ca(2+) handling impairment during atrial remodeling. (PMID:27545043)
• Induced by hepatitis C virus, miR-208b and miR-499a-5p dampen type I IFN signaling in HCV-infected hepatocytes by directly down-regulating expression of the type I IFN receptor chain, IFNAR1. (PMID:27841874)
• Circulating miR-208b may serve as a sensitive biomarker for the diagnosis and prognosis of acute myocardial infarction patients. (PMID:28164501)
• On these bases, we identified that miR-208b targets receptor tyrosine kinase-like orphan receptor 2 gene by which miR-208b can regulate the development of osteosarcoma. (PMID:28618961)
• Our data are in agreement with those of studies based on different population groups and further strengthen the observation that plasma levels of circulating miR-208b and miR-499 could serve as potential AMI biomarkers. (PMID:29475914)
• Results confirm a possible role of miR-208b as a candidate biomarker for acute myocardial infarction (AMI) diagnosis, and show that elevated miR-208b expression is associated with reduced long-term survival in AMI patients. (PMID:29977411)
• Early modulation of miR-208a in the diabetic heart induces alterations in the downstream signaling pathway leading to cardiac remodeling. (PMID:30696455)
• Diagnostic and prognostic impact of circulating microRNA-208b and microRNA-499 in patients with acute coronary syndrome. (PMID:31789049)
• Data found that increased plasma levels of miR-208b and miR-499 were significantly associated with coronary artery disease (CAD) severity. Plasma miR-208b and miR-499 can act as potential biomarkers for estimating the severity of CAD. (PMID:31885748)
• MicroRNA-208a: a Good Diagnostic Marker and a Predictor of no-Reflow in STEMI Patients Undergoing Primary Percutaneuos Coronary Intervention. (PMID:32458401)
• Diagnostic value of circulating miR-208b and miR-499 in peripheral blood of patients with acute myocardial infarction. (PMID:32495615)
• Exosomal miR-208b related with oxaliplatin resistance promotes Treg expansion in colorectal cancer. (PMID:33905821)
• MicroRNA expression profiles in familial hypertrophic cardiomyopathy with myosin-binding protein C3 (MYBPC3) gene mutations. (PMID:35717150)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-736	ENSDARG00000083623
mus_musculus	Mir208b	ENSMUSG00000077928

Paralogs (1): MIR208A (ENSG00000199157)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.