MIR210

Summary

MIR210 (microRNA 210, HGNC:31587) is a microRNA gene on chromosome 11p15.5.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406992 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31587
Approved symbol	MIR210
Name	microRNA 210
Location	11p15.5
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-210
Ensembl gene	ENSG00000199038
Ensembl biotype	miRNA
OMIM	612982
Entrez	406992
RNAcentral	URS00005FDE16 — miRNA, 110 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362168

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362168 — 1 exons

Exon	Start	End
ENSE00003544688	568089	568198

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 91.76.

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	91.76	gold quality
skin of leg	UBERON:0001511	90.77	gold quality
zone of skin	UBERON:0000014	90.41	gold quality
skin of abdomen	UBERON:0001416	89.95	gold quality
esophagus mucosa	UBERON:0002469	89.35	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.27	gold quality
vagina	UBERON:0000996	86.37	gold quality
urinary bladder	UBERON:0001255	85.54	gold quality
esophagus	UBERON:0001043	85.22	gold quality
lower esophagus mucosa	UBERON:0035834	84.84	gold quality
mucosa of transverse colon	UBERON:0004991	82.98	gold quality
metanephros cortex	UBERON:0010533	82.85	gold quality
skeletal muscle tissue	UBERON:0001134	82.27	gold quality
endometrium	UBERON:0001295	82.25	gold quality
blood	UBERON:0000178	82.07	gold quality
kidney	UBERON:0002113	81.84	gold quality
ectocervix	UBERON:0012249	81.83	gold quality
adult mammalian kidney	UBERON:0000082	81.20	gold quality
right atrium auricular region	UBERON:0006631	80.84	gold quality
lower esophagus muscularis layer	UBERON:0035833	80.75	gold quality
lower esophagus	UBERON:0013473	80.72	gold quality
apex of heart	UBERON:0002098	80.71	gold quality
tibial artery	UBERON:0007610	80.51	gold quality
popliteal artery	UBERON:0002250	80.46	gold quality
transverse colon	UBERON:0001157	80.42	gold quality
stomach	UBERON:0000945	80.11	gold quality
body of stomach	UBERON:0001161	80.10	gold quality
right uterine tube	UBERON:0001302	80.10	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	79.35	gold quality
mucosa of stomach	UBERON:0001199	79.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): HIF1A

Literature-anchored findings (GeneRIF, showing 40)

• study provides the first evidence for an oncogenic activity of miR-155, miR-203, miR-210 and miR-222 in the development of pancreatic cancer as has been reported for other tumor types (PMID:19551852)
• MiR-210 overexpression in cancer cell lines bypassed hypoxia-induced cell cycle arrest and partially reversed the hypoxic gene expression signature. (PMID:19652553)
• The data suggest that miR-210 might be involved in increased expression of gamma-globin genes in differentiating erythroid cells. (PMID:19712585)
• mir-210 may account for at least part of the repressive effect of HIF1alpha on tumor growth. (PMID:19782034)
• Results identify the iron-sulfur cluster assembly proteins (ISCU1/2) as direct targets for repression by the hypoxia-induced microRNA-210. (PMID:19808020)
• miR-210 showed dysregulation in myocardial infarction or fetal hearts when compared to healthy adults. (PMID:20075508)
• in head and neck cancer, high levels of miR-210 were associated with locoregional disease recurrence & short overall survival; miR-210 in head and neck cancer correlates with other approaches for assessing hypoxia & is associated with prognosis (PMID:20187102)
• the hypoxia component of ischemia may limit wound re-epithelialization by stabilizing HIF-1alpha, which induces miR-210 expression, resulting in the down-regulation of the cell-cycle regulatory protein E2F3 (PMID:20308562)
• miR-210 mediates a new mechanism of adaptation to hypoxia, by regulating mitochondrial function via iron-sulfur cluster metabolism and free radical generation (PMID:20436681)
• results demonstrate that miR-210 decreases mitochondrial function and upregulates the glycolysis (PMID:20498629)
• There was no relation between the expression of miRNA in hypoxic neuroblastoma cells and the amplification of MYCN. However, in all hypoxic neuroblastoma cell lines with MYCN not amplified, miR-210 was overexpressed. (PMID:20809117)
• miR-210 regulates mitochondrial function by targeting key electron transport chain component genes with important consequences on cell metabolism, survival and modulation of HIF-1 activity. (PMID:20885442)
• serum levels of miR-130a, miR-27b and miR-210 may serve as potential biomarkers for early stage atherosclerosis obliterans (PMID:20888330)
• miR-210 showed marked increases in expression in renal cancer and levels correlated with patient survival. (PMID:20964835)
• an important role for miR-210 as a tumor-suppressive microRNA with effects on cancer cell proliferation (PMID:21044961)
• role in hypoxia (Review) (PMID:21360638)
• Our study implicates an important role for mir-210 in the molecular mechanism of pre-eclampsia. (PMID:21388517)
• hypoxia-induced miR-210 represses GPD1L, contributing to suppression of prolyl hydroxylases activity, and increases of HIF-1alpha protein levels. (PMID:21555452)
• correlation between blood and brain miR-210 in ischemic mice was positive. Blood miR-210 is a novel sensitive biomarker for clinical diagnosis and prognosis in acute cerebral ischemia (PMID:21622133)
• circulating mir-210 predicts mortality in this patient cohort and may serve as a novel biomarker acute kidney injury reflecting pathophysiological changes on a cellular level. (PMID:21700819)
• miR-210 could be an interesting marker of chronic hypoxia irrespective of the androgen dependency and should, therefore, be tested as a prognostic marker in high risk prostate cancer patients (PMID:21704399)
• Expression of miR-210 is linked to tumor proliferation and appears to be a strong potential biomarker of clinical outcome in BC. (PMID:21738599)
• iron-sulfur cluster scaffold homologue down-regulation by miR-210 perturbing trophoblast iron metabolism is associated with defective placentation (PMID:21801864)
• miR-210 levels identify patients with acute rejection and predict long-term kidney function. Urinary miR-210 may thus serve as a novel biomarker of acute kidney rejection (PMID:21812927)
• up-regulated miR-210 levels in preeclampsia patients (PMID:22095477)
• vacuole membrane protein 1 (VMP1) as the direct and functional downstream target of miR-210; in addition, we show that its expression is negatively correlated with the expression of miR-210 in HCC. (PMID:22144109)
• data suggest that miR-155 and miR-210/SHIP-1/Akt pathways could serve as clinical biomarkers for disease progression, and that miR-155 and miR-210 might serve as novel therapeutic targets in myelodysplastic syndromes. (PMID:22249254)
• miR-210 is intensely expressed in osteonecrosis (ON), and might play a role in ON pathogenesis (PMID:22287106)
• Vascular endothelial growth factor augments miR-210 expression in expanded CD34+ cells. (PMID:22360314)
• miR-210 downregulation mediates enhanced radiation induced apoptosis in hypoxic human hepatoma cells through AIFM3 gene at least in part. (PMID:22387901)
• The expressions of miR-21, miR-155 and miR-210 in plasma of lymphoma patients were higher than those in the control group. (PMID:22541087)
• increased miR-181a, miR-200c and miR-210 expression was only observed in 3D cultures of human colorectal cancer cells (PMID:22641662)
• Suggest that miR-210 expression in pancreatic cancer cells is induced by hypoxia through a HIF-1alpha-dependent pathway, but does not influence tumor cell proliferation. (PMID:22672828)
• Data indicate that methylation frequency of 5 miR CpG islands (miR-9-1, miR-9-3, miR-137, miR-34b, and miR-210) gradually increased while the proportion of methylated miR-200b gradually decreased during gastric carcinogenesis. (PMID:22703336)
• In patients with acute kidney injury circulating microRNAs are not removed by dialysis. As only traces of miR-21 and -210 are detected in dialysate and ultrafiltrate, microRNAs in the circulation are likely to be transported by larger structures (PMID:22715378)
• Up-regulation of miR-210 can activate the Notch signaling pathway, which may contribute to angiogenesis after cerebral ischemia. (PMID:22833359)
• For post-operational survival, the pooled hazard ratio of higher miR-210 expression in breast cancer tissue was 3.39 (95% CI: 2.04-5.63, P<0.05), which could significantly predict poorer survival. (PMID:22842193)
• Our results have identified miR-210 as a hypoxia-inducible miRNA both in vitro and in vivo, which inhibits pulmonary vascular smooth muscle cell apoptosis in hypoxia by specifically repressing E2F3 expression. (PMID:22886504)
• miR-210 works as an iron sensor and is involved in the maintenance of iron homeostasis by sustaining the TfR expression level to stimulate cell proliferation and promote cell survival in the hypoxic region within tumors. (PMID:22896707)
• Our findings show how miR-210 induction links hypoxia to immune escape from cytotoxic T lymphocyte-mediated lysis (PMID:22962263)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.