MIR210HG

Summary

MIR210HG (MIR210 host gene, HGNC:39524) is a long non-coding RNA gene on chromosome 11p15.5.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39524
Approved symbol	MIR210HG
Name	MIR210 host gene
Location	11p15.5
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000247095
Ensembl biotype	lncRNA
Entrez	100506211
RNAcentral	URS000075D777 — lncRNA, 2303 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000500447, ENST00000528245, ENST00000533920, ENST00000534540, ENST00000665964, ENST00000688743, ENST00000688898, ENST00000692695, ENST00000702592, ENST00000827434, ENST00000827435, ENST00000827436, ENST00000827437, ENST00000827438, ENST00000827439

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500447 — 2 exons

Exon	Start	End
ENSE00004239319	568352	568449
ENSE00004239325	565660	567555

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 97.60.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1927 / max 31.8978, expressed in 605 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
117779	1.1927	605

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	97.60	gold quality
esophagus mucosa	UBERON:0002469	94.27	gold quality
skin of leg	UBERON:0001511	94.09	gold quality
zone of skin	UBERON:0000014	93.84	gold quality
skin of abdomen	UBERON:0001416	93.74	gold quality
mucosa of transverse colon	UBERON:0004991	90.42	gold quality
vagina	UBERON:0000996	90.25	gold quality
right uterine tube	UBERON:0001302	89.97	gold quality
esophagus	UBERON:0001043	89.57	gold quality
apex of heart	UBERON:0002098	89.40	gold quality
metanephros cortex	UBERON:0010533	89.06	gold quality
right atrium auricular region	UBERON:0006631	86.56	gold quality
minor salivary gland	UBERON:0001830	85.56	gold quality
transverse colon	UBERON:0001157	85.23	gold quality
saliva-secreting gland	UBERON:0001044	84.93	gold quality
lower esophagus	UBERON:0013473	84.79	gold quality
lower esophagus muscularis layer	UBERON:0035833	84.73	gold quality
right lobe of liver	UBERON:0001114	84.61	gold quality
colonic epithelium	UBERON:0000397	84.44	gold quality
heart left ventricle	UBERON:0002084	84.26	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	84.04	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	83.75	gold quality
rectum	UBERON:0001052	83.44	gold quality
cortex of kidney	UBERON:0001225	83.40	gold quality
heart	UBERON:0000948	83.16	gold quality
small intestine Peyer’s patch	UBERON:0003454	82.69	gold quality
body of stomach	UBERON:0001161	82.51	gold quality
tibial artery	UBERON:0007610	82.29	gold quality
popliteal artery	UBERON:0002250	82.27	gold quality
small intestine	UBERON:0002108	82.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.78

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• The long noncoding RNA MIR210HG promotes tumor metastasis by acting as a ceRNA of miR-1226-3p to regulate mucin-1c expression in invasive breast cancer. (PMID:31399552)
• MIR210HG promotes cell proliferation and invasion by regulating miR-503-5p/TRAF4 axis in cervical cancer. (PMID:32087604)
• Long noncoding RNA expression profiling identifies MIR210HG as a novel molecule in severe preeclampsia. (PMID:33516697)
• MIR210HG regulates glycolysis, cell proliferation, and metastasis of pancreatic cancer cells through miR-125b-5p/HK2/PKM2 axis. (PMID:34110962)
• [Expression of lncRNA MIR210HG in preeclampsia placental tissue and its functional analysis]. (PMID:34154318)
• Hypoxia-inducible lncRNA MIR210HG interacting with OCT1 is involved in glioblastoma multiforme malignancy. (PMID:34897892)
• MIR210HG is aberrantly expressed in the seminal plasma of varicocele patients and associated with varicocele-related dyszoospermia. (PMID:35146790)
• The crucial role of LncRNA MIR210HG involved in the regulation of human cancer and other disease. (PMID:36088513)
• ceRNA network of lncRNA MIR210HG/miR-377-3p/LMX1A in malignant proliferation of glioma cells. (PMID:36197580)
• Hypoxia-inducible lncRNA MIR210HG promotes HIF1alpha expression by inhibiting miR-93-5p in renal tubular cells. (PMID:37029581)
• LncRNA MIR210HG promotes the proliferation, migration, and invasion of lung cancer cells by inhibiting the transcription of SH3GL3. (PMID:37916731)
• Pan-cancer analyses identify MIR210HG overexpression, epigenetic regulation and oncogenic role in human tumors and its interaction with the tumor microenvironment. (PMID:38242493)
• Transcriptomic Analyses and Experimental Validation Identified Immune-Related lncRNA-mRNA Pair MIR210HG-BPIFC Regulating the Progression of Hypertrophic Cardiomyopathy. (PMID:38474063)
• LncRNA MIR210HG promotes phenotype switching of pulmonary arterial smooth muscle cells through autophagy-dependent ferroptosis pathway. (PMID:38635022)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.