MIR2110

Summary

MIR2110 (microRNA 2110, HGNC:37071) is a microRNA gene on chromosome 10q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302224 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37071
Approved symbol	MIR2110
Name	microRNA 2110
Location	10q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2110
Ensembl gene	ENSG00000284442
Ensembl biotype	miRNA
Entrez	100302224
RNAcentral	URS000060875E — miRNA, 75 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000459421

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000459421 — 1 exons

Exon	Start	End
ENSE00001806993	114174105	114174179

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 81.05.

Top tissues by expression

6 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	81.05	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	74.44	gold quality
blood	UBERON:0000178	72.41	gold quality
multicellular organism	UBERON:0000468	71.99	gold quality
small intestine	UBERON:0002108	70.60	gold quality
lung	UBERON:0002048	58.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Among its predicted target genes down-regulated by miR-2110, knockdown of Tsukushi (TSKU) expression showed the most potent effect in inducing cell differentiation and reducing cell survival, suggesting that TSKU protein plays a key role in mediating the functions of miR-2110. Low tumor miR-2110 levels were significantly correlated with high tumor TSKU mRNA levels. (PMID:30550571)
• Long non-coding RNA ARAP1-AS1 accelerates cell proliferation and migration in breast cancer through miR-2110/HDAC2/PLIN1 axis. (PMID:32110804)
• [miR-2110 Affects the Biological Behaviors of Lung Adenocarcinoma by Regulating CDT1]. (PMID:39507968)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.