MIR2113

Summary

MIR2113 (microRNA 2113, HGNC:37058) is a microRNA gene on chromosome 6q16.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302164 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37058
Approved symbol	MIR2113
Name	microRNA 2113
Location	6q16.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2113
Ensembl gene	ENSG00000238367
Ensembl biotype	miRNA
Entrez	100302164
RNAcentral	URS000075DC36 — ncRNA, 91 nt, 43 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000459007

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000459007 — 1 exons

Exon	Start	End
ENSE00001807571	98024531	98024621

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 77.85.

Top tissues by expression

14 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	77.85	gold quality
monocyte	CL:0000576	76.41	gold quality
blood	UBERON:0000178	70.70	gold quality
skin of leg	UBERON:0001511	67.78	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.77	gold quality
tibial nerve	UBERON:0001323	64.69	gold quality
pituitary gland	UBERON:0000007	63.86	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.29	gold quality
hypothalamus	UBERON:0001898	60.15	gold quality
corpus callosum	UBERON:0002336	58.93	gold quality
nucleus accumbens	UBERON:0001882	57.69	gold quality
caudate nucleus	UBERON:0001873	56.12	gold quality
right frontal lobe	UBERON:0002810	52.86	gold quality
left testis	UBERON:0004533	41.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• This study showed that genome-wide significant SNP-based associations within three genomic regions 6q16.1 (MIR2113), 14q12 (AKAP6/NPAS3 region) and 19q13.32 (TOMM40/APOE region) with cognition. (PMID:25644384)
• Two single nucleotide polymorphisms (SNPs), MIR211-rs10457441 and AKAP6-rs17522122 were genotyped in 1570 non-demented older Australians of European ancestry. MIR2113-rs10457441*T was associated with accelerated decline in episodic memory. No other associations with baseline cognitive performance or with linear or quadratic rate or cognitive changes were observed for this SNP. (PMID:28067462)
• Eukaryotic initiation Factor 4AIII facilitates hepatocellular carcinoma cell proliferation, migration, and epithelial-mesenchymal transition process via antagonistically binding to WD repeat domain 66 with miRNA-2113. (PMID:31975383)
• Genetic variants in MIR2113 and MIR129-LEP are associated with the susceptibility of COPD in the Chinese Han population. (PMID:32931917)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.