MIR2114

Summary

MIR2114 (microRNA 2114, HGNC:37308) is a microRNA gene on chromosome Xq28.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313839 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37308
Approved symbol	MIR2114
Name	microRNA 2114
Location	Xq28
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2114
Ensembl gene	ENSG00000252454
Ensembl biotype	miRNA
Entrez	100313839
RNAcentral	URS000075C62B — miRNA, 80 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000516645

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000516645 — 1 exons

Exon	Start	End
ENSE00002088922	150228004	150228083

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 77.64.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	77.64	gold quality
endometrium	UBERON:0001295	69.51	gold quality
right atrium auricular region	UBERON:0006631	67.85	gold quality
body of stomach	UBERON:0001161	67.59	gold quality
left adrenal gland	UBERON:0001234	67.45	gold quality
left adrenal gland cortex	UBERON:0035825	67.22	gold quality
left coronary artery	UBERON:0001626	65.65	gold quality
esophagus mucosa	UBERON:0002469	65.53	gold quality
myometrium	UBERON:0001296	65.31	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.27	gold quality
right ovary	UBERON:0002118	65.10	gold quality
omental fat pad	UBERON:0010414	64.31	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.75	gold quality
transverse colon	UBERON:0001157	63.01	gold quality
left ovary	UBERON:0002119	62.92	gold quality
tibial artery	UBERON:0007610	62.73	gold quality
right lung	UBERON:0002167	62.29	gold quality
spleen	UBERON:0002106	59.18	gold quality
nucleus accumbens	UBERON:0001882	58.18	gold quality
upper lobe of left lung	UBERON:0008952	57.75	gold quality
left testis	UBERON:0004533	38.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The role of Connexin26 regulated by MiR-2114-3p in the pathogenesis of ovarian cancer. (PMID:36565612)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.