MIR2115

Summary

MIR2115 (microRNA 2115, HGNC:37309) is a microRNA gene on chromosome 3p21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313840 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37309
Approved symbol	MIR2115
Name	microRNA 2115
Location	3p21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2115
Ensembl gene	ENSG00000252466
Ensembl biotype	miRNA
Entrez	100313840
RNAcentral	URS000075F01D — ncRNA, 100 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000516657

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000516657 — 1 exons

Exon	Start	End
ENSE00002088934	48316360	48316459

Expression profiles

Bgee: expression breadth broad, 50 present calls, max score 76.63.

Top tissues by expression

50 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	76.63	gold quality
liver	UBERON:0002107	76.34	gold quality
body of pancreas	UBERON:0001150	74.32	gold quality
body of stomach	UBERON:0001161	73.27	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.31	gold quality
endometrium	UBERON:0001295	72.11	gold quality
blood	UBERON:0000178	71.69	gold quality
Ammon’s horn	UBERON:0001954	70.30	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	70.01	gold quality
substantia nigra	UBERON:0002038	69.50	gold quality
corpus callosum	UBERON:0002336	69.04	gold quality
cerebral cortex	UBERON:0000956	68.10	gold quality
right ovary	UBERON:0002118	67.55	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.37	gold quality
intestine	UBERON:0000160	67.06	gold quality
amygdala	UBERON:0001876	67.01	gold quality
skin of abdomen	UBERON:0001416	66.85	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.54	gold quality
left ovary	UBERON:0002119	66.48	gold quality
minor salivary gland	UBERON:0001830	66.43	gold quality
lung	UBERON:0002048	66.30	gold quality
caudate nucleus	UBERON:0001873	66.05	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.02	gold quality
left adrenal gland	UBERON:0001234	65.70	gold quality
skin of leg	UBERON:0001511	65.60	gold quality
anterior cingulate cortex	UBERON:0009835	65.54	gold quality
right frontal lobe	UBERON:0002810	65.20	gold quality
prefrontal cortex	UBERON:0000451	65.15	gold quality
heart left ventricle	UBERON:0002084	65.09	gold quality
brain	UBERON:0000955	64.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.45

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA SNHG4 promotes the malignant progression of hepatocellular carcinoma through the miR-211-5p/CREB5 axis. (PMID:36565037)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.