MIR2116

Summary

MIR2116 (microRNA 2116, HGNC:37310) is a microRNA gene on chromosome 15q22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313886 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37310
Approved symbol	MIR2116
Name	microRNA 2116
Location	15q22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2116
Ensembl gene	ENSG00000253030
Ensembl biotype	miRNA
Entrez	100313886
RNAcentral	URS000075B884 — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000517221

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000517221 — 1 exons

Exon	Start	End
ENSE00002089498	59171183	59171262

Expression profiles

Bgee: expression breadth broad, 97 present calls, max score 85.32.

Top tissues by expression

97 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	85.32	gold quality
prefrontal cortex	UBERON:0000451	84.24	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.32	gold quality
vermiform appendix	UBERON:0001154	80.37	gold quality
liver	UBERON:0002107	79.40	gold quality
placenta	UBERON:0001987	77.91	gold quality
monocyte	CL:0000576	77.33	gold quality
blood	UBERON:0000178	75.99	gold quality
adrenal tissue	UBERON:0018303	74.32	gold quality
islet of Langerhans	UBERON:0000006	74.12	gold quality
tonsil	UBERON:0002372	73.07	gold quality
kidney	UBERON:0002113	72.84	gold quality
gastrocnemius	UBERON:0001388	72.30	gold quality
endometrium	UBERON:0001295	71.53	gold quality
adenohypophysis	UBERON:0002196	71.32	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.81	gold quality
rectum	UBERON:0001052	70.65	gold quality
lymph node	UBERON:0000029	70.54	gold quality
adult mammalian kidney	UBERON:0000082	70.46	gold quality
right lobe of liver	UBERON:0001114	70.36	gold quality
gall bladder	UBERON:0002110	70.33	gold quality
stomach	UBERON:0000945	70.22	gold quality
heart	UBERON:0000948	70.15	gold quality
descending thoracic aorta	UBERON:0002345	69.13	gold quality
tibial artery	UBERON:0007610	69.10	gold quality
popliteal artery	UBERON:0002250	69.05	gold quality
heart left ventricle	UBERON:0002084	68.99	gold quality
Ammon’s horn	UBERON:0001954	68.64	gold quality
right atrium auricular region	UBERON:0006631	68.55	gold quality
adrenal gland	UBERON:0002369	68.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.54

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• interaction between LINC01433 and miR-2116-3p was verified in BC. Additionally, MYC was validated as a target gene of miR-2116-3p (PMID:30939038)
• both miR-3197 and miR-2116-5p were identified as promising diagnostic biomarkers for diabetic retinopathy (PMID:31678272)
• Long non-coding RNA FALEC promotes colorectal cancer progression via regulating miR-2116-3p-targeted PIWIL1. (PMID:33073675)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.