MIR2117

Summary

MIR2117 (microRNA 2117, HGNC:37311) is a microRNA gene on chromosome 17q21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313779 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37311
Approved symbol	MIR2117
Name	microRNA 2117
Location	17q21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2117
Ensembl gene	ENSG00000284344
Ensembl biotype	miRNA
Entrez	100313779
RNAcentral	URS000075C1B8 — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000516780

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000516780 — 1 exons

Exon	Start	End
ENSE00002089057	43444806	43444885

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 67.93.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
minor salivary gland	UBERON:0001830	67.93	gold quality
heart left ventricle	UBERON:0002084	66.10	gold quality
esophagus mucosa	UBERON:0002469	65.52	gold quality
vagina	UBERON:0000996	64.70	gold quality
right lobe of liver	UBERON:0001114	63.18	gold quality
skin of abdomen	UBERON:0001416	62.94	gold quality
left lobe of thyroid gland	UBERON:0001120	61.51	gold quality
spleen	UBERON:0002106	59.67	gold quality
multicellular organism	UBERON:0000468	53.07	gold quality
pituitary gland	UBERON:0000007	51.59	gold quality
left testis	UBERON:0004533	32.80	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.