MIR212

Summary

MIR212 (microRNA 212, HGNC:31589) is a microRNA gene on chromosome 17p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406994 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31589
Approved symbol	MIR212
Name	microRNA 212
Location	17p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-212
Ensembl gene	ENSG00000267195
Ensembl biotype	miRNA
OMIM	613487
Entrez	406994
RNAcentral	URS00003AD7BA — miRNA, 110 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000586026

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000586026 — 1 exons

Exon	Start	End
ENSE00003624989	2050271	2050380

Expression profiles

Bgee: expression breadth broad, 66 present calls, max score 91.91.

Top tissues by expression

66 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	91.91	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.55	gold quality
right lobe of liver	UBERON:0001114	79.31	gold quality
liver	UBERON:0002107	77.35	gold quality
bone marrow	UBERON:0002371	75.45	gold quality
blood	UBERON:0000178	75.05	gold quality
omental fat pad	UBERON:0010414	73.99	gold quality
gastrocnemius	UBERON:0001388	73.72	gold quality
right atrium auricular region	UBERON:0006631	73.03	gold quality
stomach	UBERON:0000945	72.92	gold quality
body of pancreas	UBERON:0001150	72.58	gold quality
body of stomach	UBERON:0001161	72.28	gold quality
heart left ventricle	UBERON:0002084	72.05	gold quality
vagina	UBERON:0000996	71.65	gold quality
left adrenal gland cortex	UBERON:0035825	71.06	gold quality
left coronary artery	UBERON:0001626	70.87	gold quality
hypothalamus	UBERON:0001898	69.86	gold quality
left adrenal gland	UBERON:0001234	69.85	gold quality
ascending aorta	UBERON:0001496	69.51	gold quality
myometrium	UBERON:0001296	69.38	gold quality
skin of abdomen	UBERON:0001416	68.94	gold quality
pituitary gland	UBERON:0000007	68.90	gold quality
Ammon’s horn	UBERON:0001954	68.76	gold quality
left ovary	UBERON:0002119	68.72	gold quality
fundus of stomach	UBERON:0001160	68.68	gold quality
right adrenal gland	UBERON:0001233	68.65	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.26	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.92	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.86	gold quality
transverse colon	UBERON:0001157	67.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): FIGLA, KDM5A, MBD2

Literature-anchored findings (GeneRIF, showing 40)

• The aims of our study were: (i) to investigate the effect of alcohol on miRNA-212 (miR-212) and on expression of its predicted target gene, ZO-1, (ii) to study the potential role of miR-212 in the pathophysiology of ALD in man. (PMID:18162065)
• Downregulation of miR-212 is associated with gastric cancer. (PMID:20020497)
• Expression of HB-EGF is regulated by miR-212 in head and neck squamous cell carcinoma. (PMID:20856931)
• miR-212 expression is significantly reduced in gastric cancer cells compared to normal gastric mucosa cells. (PMID:21053104)
• over-expression of miR-132 and miR-212 result in reduced pRb protein in pancreatic cancer cells. (PMID:21329664)
• Data indicate that STAT4 might be the molecular target of miR-132, miR-212, and miR-200a. (PMID:22077060)
• histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC (PMID:22110741)
• miR-212 and miR-328 were identified to correlate inversely with ABCG2 expression under long-term imatinib treatment (PMID:22241070)
• results indicated that miR-212 was involved in tumorigenesis, and the oncogenic activity of miR-212 in non-small cell lung cancer cells was due, in part, to suppression of PTCH1 (PMID:22357618)
• Low miR-212 expression is associated with acute myeloid leukemia. (PMID:22692398)
• The targeting of the K(ir)2.1 3’UTR at bp 2677-2683 by miR-212 results in a decrease in the red/green fluorescence intensity ratio as determined by automated image analysis confirmed the mutations at this site alter the binding. (PMID:22880819)
• Cardiomyocyte-specific overexpression of the /132 family leads to pathological cardiac hypertrophy, heart failure and death in mice. (PMID:23011132)
• During bacterial infection, PGN-mediated TLR2 signaling induces miR-132/-212 to downregulate IRAK4. (PMID:23264652)
• miR-212 expression was significantly down-regulated in postpartum psychosis patients with prior bipolar disorder (PMID:23295264)
• miR-212 is down-regulated in human colorectal cancer tissues via genetic and epigenetic mechanisms. miR-212 might prevent tumor progression by targeting manganese superoxide dismutase messenger RNA. (PMID:23583431)
• De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer’s disease. (PMID:23585551)
• miR-132 and miR-212 are involved in AngII induced hypertension. (PMID:23712358)
• MiR-212 directly regulates the expression of RBP2 and inhibits cell growth in gastric cancer, which may provide new clues to treatment. (PMID:23794145)
• RBP2 is overexpressed in HCC and negatively regulated by hsa-miR-212. The hsa-miR-212-RBP2-CDKI pathway may be important in the pathogenesis of HCC. (PMID:23922798)
• Synaptic acetylcholinesterase may be a tumor suppressor and is modulated by miR-212 in non-small cell lung cancer. (PMID:23974008)
• miR-212 expression is a critical element in cocaine-addiction. (PMID:24338410)
• MiR-212 may facilitate pancreatic ductal adenocarcinoma progression and metastasis through targeting PTCH1. (PMID:24961235)
• the regulatory role of miR-212-3p in the expression of the CD80 protein (PMID:24981235)
• MiR-212 exerts suppressive effect on SKOV3 ovarian cancer cells through targeting HBEGF. (PMID:25201063)
• These observations suggest that Lin28B:miR-212 may work as a regulatory loop in androgen-independent prostate cancer (PMID:25201220)
• Findings suggest that miR-212/132 may be a novel tumor-suppressor by blocking the proliferation and migration, of lung cancer cells through modulating the expression of p21 and cyclin D1. (PMID:25435090)
• Data indicat a strong decrease in the level of sirtuin 1 (SIRT1) protein was observed in samples transfected with microRNAs miR-132 and miR-212 or hSirt1-specific siRNA. (PMID:25483038)
• The miR-212/Sox4 interaction plays an important role of in the osteosarcoma progression. (PMID:25562164)
• induction of miR-132/212 following bladder outlet obstruction: association with MeCP2 repression and cell viability (PMID:25617893)
• results support a model involving miR-132 and miR-212 upregulation in sustaining disease progression in chronic lymphocytic leukemia. (PMID:25645730)
• Increased expression level of miR212 is associated with schizophrenia. (PMID:25656957)
• This study demonstrated that miR-212-3p was down-regulated in glioma specimens of WHO grade III and IV, associated with a higher level of SGK3. (PMID:25720694)
• In conclusion, miR-212 may serve as a prognostic indicator for HCC patients and exerts tumor suppressive role, at least in part, by inhibiting FOXA1. (PMID:25965836)
• Data show a negative correlation between microRNA miR-212-3p and regulatory factor X-associated protein (RFXAP) in pancreatic cancer (PC) tissue. (PMID:26337469)
• miR-132 and miR-212 levels correlated with insoluble tau and cognitive impairment in humans. (PMID:26362250)
• Taken together, the findings provide the first evidences of the synergistic anti-metastatic properties of miR-212/132 cluster through suppression of SOX4. (PMID:26377202)
• human chorionic gonadotropin stimulated miR-212, which down-regulated OLFM1 and CTBP1 expression in fallopian and endometrial epithelial cells to favor spheroid attachment (PMID:26377223)
• our study indicates a functional role of miR-212 in prostate cancer. (PMID:26439987)
• Dysregulation of miR-212 Promotes Castration Resistance through hnRNPH1-Mediated Regulation of AR and AR-V7 (PMID:26553749)
• To confirm the reliability of the analyses, we identified that the metastasis-related gene ZO-1 is a certain target of miR-212 in CRC and keeps declining during colorectal cancers progression (PMID:26692142)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-212	ENSDARG00000080565
danio_rerio		ENSDARG00000089119
rattus_norvegicus	Mir212	ENSRNOG00000035476

Paralogs (1): MIR132 (ENSG00000267200)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.