MIR217

Summary

MIR217 (microRNA 217, HGNC:31594) is a microRNA gene on chromosome 2p16.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406999 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31594
Approved symbol	MIR217
Name	microRNA 217
Location	2p16.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-217, miR-217
Ensembl gene	ENSG00000207548
Ensembl biotype	miRNA
OMIM	615096
Entrez	406999
RNAcentral	URS0000060B2B — miRNA, 110 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384817

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384817 — 1 exons

Exon	Start	End
ENSE00001499824	55982967	55983076

Expression profiles

Bgee: expression breadth broad, 22 present calls, max score 79.64.

Top tissues by expression

22 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	79.64	gold quality
monocyte	CL:0000576	75.55	gold quality
muscle layer of sigmoid colon	UBERON:0035805	73.33	gold quality
islet of Langerhans	UBERON:0000006	73.17	gold quality
intestine	UBERON:0000160	69.56	gold quality
body of stomach	UBERON:0001161	69.16	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.64	gold quality
tibial nerve	UBERON:0001323	66.82	gold quality
transverse colon	UBERON:0001157	66.40	gold quality
omental fat pad	UBERON:0010414	66.09	gold quality
blood	UBERON:0000178	65.45	gold quality
left lobe of thyroid gland	UBERON:0001120	64.87	gold quality
skin of leg	UBERON:0001511	64.79	gold quality
upper lobe of left lung	UBERON:0008952	63.89	gold quality
stomach	UBERON:0000945	63.20	gold quality
spleen	UBERON:0002106	61.92	gold quality
Ammon’s horn	UBERON:0001954	61.01	gold quality
corpus callosum	UBERON:0002336	54.60	gold quality
pituitary gland	UBERON:0000007	54.30	silver quality
left testis	UBERON:0004533	49.78	gold quality
right testis	UBERON:0004534	48.65	gold quality
testis	UBERON:0000473	48.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• MicroRNA-217 is found to be an endogenous inhibitor of silent information regulator 1 in endothelial cell senescence. (PMID:19786632)
• frequently downregulated miR-217 can regulate KRAS and function as a tumor suppressor in pancreatic ductal adenocarcinoma (PDAC). (PMID:20675343)
• the combination of miR-377 and miR-217 help regulate HO-1 protein expression in the presence of hemin (PMID:21106538)
• Studies indicate that miR-21, miR-196a, and miR-217 are among the diagnostic, predictive, and prognostic microRNA profiling in pancreatic ductal adenocarcinoma. (PMID:22001830)
• MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1. (PMID:22308024)
• These results uncover previously unknown links between Tat and a specific host cell miRNA that targets SIRT1. (PMID:22406815)
• Data shsow that miR-363, miR-490, miR-137, miR-217 and miR-4792 were the top five significantly de-regulated miRNAs in uterine leiomyoma (ULM). (PMID:22446413)
• Data indicate that three miRs (miR-484, -642, and -217) were able to predict chemoresistance and vasculature of serous epithelial ovarian carcinomas through the regulation of the VEGFB and VEGFR2 pathways (PMID:23697367)
• miR-217 plays a tumor suppressor role in clear cell renal cell carcinoma (PMID:23790169)
• Philadelphia chromosome positive leukemia cells acquire tyrosine kinase inhibtor resistance via downregulation of miR-217 and upregulation of DNMT3A. (PMID:24350829)
• HCMV infection of endothelial cells induces angiogenesis by both of miR-217/SIRT1 and miR-217/FOXO3A axis (PMID:24376725)
• findings suggest miR-217 function as a potential tumor suppressor in HCC progression and miR-217-E2F3 axis may be a novel candidate for developing rational therapeutic strategies (PMID:24671492)
• MiR-217 inhibitor promoted EMT in PC cells but not in SIRT-knockdown PC cells. (PMID:25172416)
• miR-217 suppresses tumour development in lung cancer by targeting KRAS and enhances cell sensitivity to cisplatin. (PMID:25234467)
• Low mirn217 expression is associated with proliferation, migration, and invasion of esophageal squamous cell carcinoma. (PMID:25538231)
• Epigenetic repression of miR-217 contributes to the pathogenesis of EAC via upregulation of KLK7. (PMID:25703328)
• renal proximal tubule cells from subjects carrying D2R SNPs resulting in D2R downregulation have increased TGFbeta1 that is mediated by decreased regulation of the miR-217-Wnt5a-Ror2 pathway. (PMID:25801876)
• microRNA-217 inhibits tumor progression and metastasis by downregulating EZH2 and predicts favorable prognosis in gastric cancer. (PMID:25869101)
• MiR-21, miR-34a, miR-198 and miR-217 are diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma (PMID:25908274)
• miR-217 may act as a tumor suppressor in osteosarcoma. (PMID:25960216)
• ectopic miR-217 expression decreased AEG-1 expression and repressed luciferase reporter activity associated with the AEG-1 3’-untranslated region (UTR). (PMID:26016795)
• miR-217 functions as a tumor suppressor in osteosarcoma by suppressing Wnt5a expression. (PMID:26054690)
• Taken together, our results demonstrate a role for miR-217 in the regulation of keratinocyte differentiation, partially through the regulation of GRHL2. (PMID:26826389)
• miR-217-CAGE feedback loop serves as a target for overcoming resistance to various anti-cancer drugs, including EGFR and HER2 inhibitors. (PMID:26863629)
• Results show that miR-30a and miR-217 forms a negative feedback loop to regulate the expression of each other and the response to anti-cancer drugs. (PMID:26912082)
• findings show that miR-200b, miR-200c, and miR-217 regulate mortalin expression and activity and, as a result, regulate the quantity of membrane attack complexes deposited on target cells during complement activation, and thus contribute to cell resistance to complement-dependent cytotoxicity (PMID:27183614)
• MicroRNA-217 regulates vascular smooth muscle cell proliferation and migration. (PMID:27333430)
• Data suggest that, compared with control, serum levels of microRNA 217 are significantly increased in type 2 diabetes patients and gradually increase in patients with normoalbuminuria, microalbuminuria, and macroalbuminuria due to progression of diabetic nephropathy. (PMID:27522360)
• downregulation of miR-34a and miR-217 was correlated with aggressive progression and poor prognosis in patients with hepatocellular carcinoma. miR-34a and miR-217 could be a independent biomarkers and act as novel therapeutic agents for the treatment of hepatocellular carcinoma. (PMID:27879964)
• This study concludes that MiR-217 is the upstream regulator of PGC-1alpha in breast cancer regulation in vitro, possibly independent of DACH1 signaling pathway. (PMID:27916422)
• MiR-217 could promote the viability, proliferation, migration, invasion and mitosis of glioblastoma cells both in vitro and in vivo. (PMID:28126486)
• Low miR217 expression is associated with hepatocellular carcinoma. (PMID:28184926)
• MiR-217 was downregulated in glioma tissues and cell lines. Upregulated circ-TTBK2 decreased miR-217 expression and there was a reciprocal negative feedback between them. Moreover, reintroduction of miR-217 significantly reversed circ-TTBK2-mediated promotion of glioma progression. (PMID:28219405)
• these findings revealed that miR-217 promotes fibroblasts senescence by suppressing DNMT1-mediated methylation of p16 and pRb by targeting the DNMT1 3’-UTR. (PMID:28380423)
• miR-217 suppresses triple-negative breast cancer cell growth, migration, and invasion. MiR-217 suppresses triple-negative breast cancer, at least partially, through down-regulating the KLF5 expression. (PMID:28437471)
• Mir-217 is directly targets TCF7L2 and TCF7L2 repression and subsequent inhibition of Wnt/beta-catenin signaling pathway. (PMID:28472810)
• Abnormal expression of hsa-miR-96 and of hsa-miR-217 was observed in premalignant lesions (PanINs and IPMNs) of pancreatic carcinoma and down-regulated with increasing grades of PanINs and IPMNs. These microRNAs may serve as potentially early biomarker and act as tumor suppressor genes (PMID:28539816)
• miR-217 inhibited the proliferation and promoted the apoptosis of primary cardiac myxoma cells by targeting IL-6. (PMID:28642131)
• MALAT1 acts as a tumour promoter at least in part by binding miR-217 and sequestering the molecule in the nucleus, thereby promoting oncogenic KRAS expression in PDAC. (PMID:28701723)
• Our results showcase the potentially valuable functional impact of microRNAs in regulating GG related epilepsy. As CK-2alpha inhibition enhances miR-217 expression, disrupting the miR-217-CK-2alpha interplay through CK-2alpha inhibitors might represent a novel therapeutic strategies aimed at LEAT. (PMID:28840260)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir217-1	ENSDARG00000083272
rattus_norvegicus	Mir217	ENSRNOG00000035518

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.