MIR217HG

Summary

MIR217HG (MIR217 host gene, HGNC:50537) is a long non-coding RNA gene on chromosome 2p16.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50537
Approved symbol	MIR217HG
Name	MIR217 host gene
Location	2p16.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	MIR216AHG, MIR216BHG
Ensembl gene	ENSG00000226702
Ensembl biotype	lncRNA
Entrez	104355290
RNAcentral	URS00007E3EB3 — lncRNA, 685 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 22 lncRNA

ENST00000446139, ENST00000701602, ENST00000752937, ENST00000752938, ENST00000752939, ENST00000752940, ENST00000752941, ENST00000752942, ENST00000752943, ENST00000752944, ENST00000752945, ENST00000752946, ENST00000752947, ENST00000752948, ENST00000752949, ENST00000752950, ENST00000752951, ENST00000752952, ENST00000752953, ENST00000752954, ENST00000752955, ENST00000752956

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000446139 — 4 exons

Exon	Start	End
ENSE00001640415	56013609	56013711
ENSE00004099595	56047222	56047487
ENSE00004099602	56049124	56049678
ENSE00004099605	55963191	55963882

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 93.61.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0338 / max 58.3196, expressed in 2 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
28516	0.0338	2

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	93.61	gold quality
pancreas	UBERON:0001264	84.59	gold quality
islet of Langerhans	UBERON:0000006	68.00	gold quality
myometrium	UBERON:0001296	58.97	gold quality
right coronary artery	UBERON:0001625	55.30	gold quality
multicellular organism	UBERON:0000468	53.75	gold quality
endometrium	UBERON:0001295	53.38	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	53.23	gold quality
tibial artery	UBERON:0007610	52.65	gold quality
popliteal artery	UBERON:0002250	52.57	gold quality
ascending aorta	UBERON:0001496	52.26	gold quality
monocyte	CL:0000576	52.19	silver quality
thoracic aorta	UBERON:0001515	52.13	gold quality
cortex of kidney	UBERON:0001225	50.48	gold quality
prefrontal cortex	UBERON:0000451	50.22	gold quality
skin of abdomen	UBERON:0001416	49.76	gold quality
urinary bladder	UBERON:0001255	49.68	gold quality
frontal cortex	UBERON:0001870	47.39	gold quality
placenta	UBERON:0001987	46.45	gold quality
descending thoracic aorta	UBERON:0002345	46.18	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	46.12	gold quality
Brodmann (1909) area 9	UBERON:0013540	46.08	gold quality
left coronary artery	UBERON:0001626	46.01	gold quality
hypothalamus	UBERON:0001898	45.80	gold quality
cerebral cortex	UBERON:0000956	45.79	gold quality
heart	UBERON:0000948	45.57	gold quality
blood	UBERON:0000178	45.53	silver quality
omental fat pad	UBERON:0010414	45.44	gold quality
right lobe of liver	UBERON:0001114	45.37	silver quality
ovary	UBERON:0000992	45.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.61

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA MIR217HG aggravates pressure-overload induced cardiac remodeling by activating miR-138/THBS1 pathway. (PMID:38013141)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.