MIR218-1

Summary

MIR218-1 (microRNA 218-1, HGNC:31595) is a microRNA gene on chromosome 4p15.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 407000 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31595
Approved symbol	MIR218-1
Name	microRNA 218-1
Location	4p15.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-218-1
Ensembl gene	ENSG00000207732
Ensembl biotype	miRNA
OMIM	616770
Entrez	407000
RNAcentral	URS0000332092 — miRNA, 110 nt, 33 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384999

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384999 — 1 exons

Exon	Start	End
ENSE00001500006	20528275	20528384

Expression profiles

Bgee: expression breadth broad, 66 present calls, max score 83.48.

Top tissues by expression

66 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	83.48	gold quality
calcaneal tendon	UBERON:0003701	79.89	gold quality
adrenal tissue	UBERON:0018303	78.25	gold quality
stomach	UBERON:0000945	77.47	gold quality
adult mammalian kidney	UBERON:0000082	75.77	gold quality
liver	UBERON:0002107	75.46	gold quality
islet of Langerhans	UBERON:0000006	73.02	gold quality
heart	UBERON:0000948	72.33	gold quality
right atrium auricular region	UBERON:0006631	71.91	gold quality
right frontal lobe	UBERON:0002810	71.88	gold quality
body of pancreas	UBERON:0001150	71.80	gold quality
lung	UBERON:0002048	71.66	gold quality
blood	UBERON:0000178	71.59	gold quality
endometrium	UBERON:0001295	71.58	gold quality
mucosa of stomach	UBERON:0001199	71.07	gold quality
body of stomach	UBERON:0001161	70.61	gold quality
intestine	UBERON:0000160	70.46	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.20	gold quality
corpus callosum	UBERON:0002336	69.72	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.64	gold quality
ascending aorta	UBERON:0001496	69.01	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.99	gold quality
esophagus mucosa	UBERON:0002469	68.80	gold quality
heart left ventricle	UBERON:0002084	68.61	gold quality
tibial artery	UBERON:0007610	68.52	gold quality
colon	UBERON:0001155	68.49	gold quality
left adrenal gland	UBERON:0001234	68.23	gold quality
urinary bladder	UBERON:0001255	67.68	gold quality
minor salivary gland	UBERON:0001830	67.48	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.26

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• Down-regulation of miR-218 is associated with prostate cancer metastasis. (PMID:19372056)
• These results describe a Slit-miR-218-Robo1 regulatory circuit whose disruption may contribute to gastric cancer metastasis. (PMID:20300657)
• miR-218 expression is reduced in gastric cancer, and may function as a tumor suppressor. (PMID:20510072)
• MIR218-1 and MIR218-2 are deleted and downregulated in lung squamous cell carcinoma. (PMID:20838434)
• Data indicate that LASP1 may have an oncogenic function and that it might be regulated by miR-1, miR-133a, and miR-218, which may function as tumor suppressive miRNAs in bladder cancer (BC). (PMID:20843712)
• miR-218 plays an important role in preventing the invasiveness of glioma cells, and this results present a novel mechanism of miRNA-mediated direct suppression of IKK-beta/NF-kappaB pathway in gliomas. (PMID:20933503)
• Down-regulation of miR-218 was involved in the pathogenesis of cervical cancer. (PMID:21309487)
• Data show direct interaction between miR-218 and the 3’UTR of mRNAs encoding ROBO1, survivin (BIRC5), and connexin43 (GJA1). (PMID:21385904)
• Our study is the first to demonstrate that miR-218 located on chrosomosme 4p15.31 is a tumor suppressive miRNA in bladder cancer (BC). (PMID:21519788)
• miR-585 is a tumor suppressor that is often epigenetically silenced in oral squamous cell carcinoma. (PMID:21795477)
• Pri-miR-218 polymorphism is associated with hepatocellular carcinoma. (PMID:22011248)
• An aberrant decrease of miR-218 expression may lead to an increase of CDK6 expression and proliferative activity of giloma cells. (PMID:22088371)
• Data suggest microRNA-218 was deregulated in most cervical cancer patients and associated with tumor invasion. (PMID:22237456)
• the expression levels of miR-7 and miR-218 were strongly and reversely associated with HoxB3 expression. (PMID:22705304)
• miR-218 is involved in the invasive behavior of glioblastoma cells by targeting LEF1 and blocking the invasive axis. (PMID:22766851)
• positive correlation between miRNA-218 and GLCE mRNA, and negative correlation between miRNA-218 and GLCE protein levels in breast tissues and primary tumors in vivo, supporting a direct involvement of miRNA-218 in posttranscriptional regulation of GLCE (PMID:22968430)
• MiR-218 inhibits medulloblastoma tumor cell phenotype by targeting multiple oncogenes. (PMID:23212916)
• Downregulation of miRNA 218 is associated with glioma. (PMID:23243056)
• miR-218 suppressed protein expression of BMI-1 downstream targets of cyclin-dependent kinase 4, a cell cycle regulator, while upregulating protein expression of p53. (PMID:23255074)
• The identification of novel tumor-suppressive miR-218-mediated molecular pathways has provided new insights into cervical SCC oncogenesis and metastasis (PMID:23483249)
• No association of functional variant in pri-miR-218 and risk of congenital heart disease in a Chinese population. (PMID:23566829)
• Downregulation of miRNA-218 and upregulation of ROBO-1 were first demonstrated in pancreatic cancer. (PMID:23733161)
• miR-218 was downregulated in osteosarcoma. (PMID:23886165)
• Loss of MicroRNA-218 is associated with glioma. (PMID:23950210)
• MIR218 functions as a tumor suppressor by regulating SH3GL1 expression in medulloblastoma cancer cells. (PMID:23970061)
• a regulatory network with a central role for the miR-218 in human adipose-derived stem cell osteogenic differentiation, is reported. (PMID:24091133)
• rs11134527 may be a novel genetic risk factor of hepatocellular carcinoma in hepatitis B virus-exposed subjects. (PMID:24118778)
• Data indicate that miR-218 suppressed the expression of high mobility group box-1 (HMGB1) by directly targeting its 3’-untranslated region. (PMID:24247270)
• result showed that microRNA218 targeted directly the N terminus of GLI1 molecular, and repressed the GLI1 expression in U87MG cells (PMID:24357514)
• there is an miR-218-RTK-HIF2alpha signaling axis that promotes GBM cell survival and tumor angiogenesis, particularly in necrotic mesenchymal tumors (PMID:24368849)
• Compared with the control group, the expression of KIT protein in the GIST-T1 cells transfected with miR-218 mimic for 48 h significantly decreased (P < 0.01) (PMID:24375253)
• These results suggest that miR-218 regulates the ability of TGFbeta to induce myofibroblast differentiation in fibroblasts via cezanne/FAK. (PMID:24501422)
• ADAM9 up-regulates N-cadherin via miR-218 suppression in lung adenocarcinoma cells. (PMID:24705471)
• pre-mir-218 polymorphism is associated with cancer risk. (PMID:24761857)
• MicroRNA-218 inhibits melanogenesis by directly suppressing microphthalmia-associated transcription factor expression. (PMID:24824743)
• miR-218 is downregulated in melanoma. By targeting CIP2A and BMI1, miR-218 regulates the proliferation, migration, and invasion of the melanoma cell lines A375 and SK-MEL-2. (PMID:24839010)
• apoptosis. Moreover, we proved that miR-218 as a potent predictor of radiosensitivity in cervical cancer, especially for those patients with loss of miR-218. (PMID:24843318)
• Low-miR-218 expression is associated with oral cavity squamous cell carcinoma. (PMID:24894864)
• miR-218 is deregulated in gastric cancer patients and is strongly correlated with tumor stage, grade and metastasis. (PMID:24944481)
• miRNA-218 acted as a tumor suppressor in pancreatic cancer by inhibiting cell invasion and migration. (PMID:25010661)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir218-1	ENSMUSG00000065603

Paralogs (1): MIR218-2 (ENSG00000207739)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.