MIR219A1

Summary

MIR219A1 (microRNA 219a-1, HGNC:31597) is a microRNA gene on chromosome 6p21.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 407002 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31597
Approved symbol	MIR219A1
Name	microRNA 219a-1
Location	6p21.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-219-1
Ensembl gene	ENSG00000199036
Ensembl biotype	miRNA
OMIM	611500
Entrez	407002
RNAcentral	URS0000173F7B — miRNA, 110 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362166

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362166 — 1 exons

Exon	Start	End
ENSE00001436929	33207835	33207944

Expression profiles

Bgee: expression breadth ubiquitous, 107 present calls, max score 91.50.

Top tissues by expression

107 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	91.50	gold quality
granulocyte	CL:0000094	89.77	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	84.61	gold quality
monocyte	CL:0000576	79.79	gold quality
bone marrow	UBERON:0002371	79.22	gold quality
smooth muscle tissue	UBERON:0001135	78.46	gold quality
endometrium	UBERON:0001295	77.30	gold quality
ectocervix	UBERON:0012249	75.92	gold quality
adrenal tissue	UBERON:0018303	75.91	gold quality
right adrenal gland	UBERON:0001233	75.63	gold quality
blood	UBERON:0000178	75.17	gold quality
pancreas	UBERON:0001264	74.58	gold quality
body of pancreas	UBERON:0001150	74.42	gold quality
endocervix	UBERON:0000458	74.40	gold quality
islet of Langerhans	UBERON:0000006	73.86	gold quality
fundus of stomach	UBERON:0001160	73.70	gold quality
right adrenal gland cortex	UBERON:0035827	73.67	gold quality
left ovary	UBERON:0002119	73.59	gold quality
left adrenal gland cortex	UBERON:0035825	73.52	gold quality
myometrium	UBERON:0001296	73.51	gold quality
adrenal gland	UBERON:0002369	73.32	gold quality
ovary	UBERON:0000992	73.27	gold quality
pituitary gland	UBERON:0000007	73.18	gold quality
liver	UBERON:0002107	73.03	gold quality
muscle of leg	UBERON:0001383	72.91	gold quality
gastrocnemius	UBERON:0001388	72.90	gold quality
stomach	UBERON:0000945	72.75	gold quality
left adrenal gland	UBERON:0001234	72.75	gold quality
body of stomach	UBERON:0001161	72.56	gold quality
right uterine tube	UBERON:0001302	72.43	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• These findings indicate that miR-219-5p exerts tumor-suppressive effects in hepatic carcinogenesis through negative regulation of glypican 3 expression [MiR-219-5p]. (PMID:22449976)
• This result suggests that polymorphisms in the pri-miRNA region of miR-219-1 might be a genetic factor for hepatitis B virus clearance after infection. (PMID:23508906)
• miR-219-5p inhibits receptor tyrosine kinase pathway by targeting epidermal growth factor receptor in glioblastoma. (PMID:23690991)
• findings suggest that long-term night shiftwork exposure may lead to the methylation-dependent downregulation of miR-219, which may in turn lead to the downregulation of immunomediated antitumor activity and increased breast cancer risk (PMID:23813567)
• these results identify miR-219-1-3p as a new negative regulator of MUC4 oncomucin that possesses tumor-suppressor activity in Pancreatic ductal adenocarcinoma (PMID:24608432)
• miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164. (PMID:24756834)
• The results of this study concluded that methylation-mediated epigenetic modification of spinal miR-219 expression regulates chronic inflammatory pain by targeting CaMKIIgamma. (PMID:25031391)
• Single nucleotide polymorphism in mir219-1 is associated with colorectal cancer. (PMID:25368035)
• miR-219 plays a crucial role in suppressing seizure formation in experimental models of epilepsy through modulating the CaMKII/NMDA receptor pathway (PMID:25394384)
• Our investigation identified miR-219-5p as a negative regulator of papillary thyroid carcinoma development through targeting of ERalpha. (PMID:25423566)
• This study found hsa-miR-219a-5p target methylation to be associated with hippocampal volume - a schizophrenia-related intermediate phenotype. (PMID:25598502)
• these studies demonstrate that miR-219-5p inhibited cancer cell growth and invasion by direct targeting ROBO1, implicating miR-219-5p as an attractive candidate for cancer therapy. (PMID:26081620)
• The results show that miR-219-5p inhibited carcinogenesis of colon cancer by targeting oncogene Sall4 (PMID:26238082)
• TLX and miR-219 have an important role in both normal neurodevelopment and in schizophrenia patient iPSC-derived NSCs. TLX has a role in regulating microRNA processing, independent of its well-characterized role in transcriptional regulation. (PMID:26965827)
• Suppression of miR-219-5p may benefit the liver regeneration and prevent cirrhosis through increasing KGF. (PMID:27855391)
• study found that miR-219-1 rs213210 polymorphism was associated with GC susceptibility and rs11134527 in miR-218 was positively correlated with GC prognosis (PMID:28298809)
• The upregulation of miR-219-5p inhibited melanoma growth and metastasis and strengthened melanoma cells chemosensitivity by targeting Bcl-2. Therefore, the modulation of miR-219-5p expression may be a novel treatment strategy in melanoma. (PMID:28884131)
• Low expression of miR219 is associated with invasion of epithelial ovarian cancer. (PMID:28890378)
• the tumor suppressive role of miR-219a-5p in regulating breast cancer migration by targeting MRTF-A. (PMID:29077787)
• We have been able to identify and validate absence of miR-219 detection in CSF of multiple sclerosis patients compared to controls (PMID:29202778)
• miR-219-5p could inhibit wound healing by targeting TMEM98 in keratinocytes. (PMID:30338788)
• study revealed that miR-219a-5p function as tumour suppressor regulates osteosarcoma cell invasiveness by repressing EYA2 expression. (PMID:30449183)
• the results of the present study revealed that miR219 may regulate profibrotic markers by directly targeting the TGFBR2 gene and the miR219/TGFBR2 signaling pathway may be a potential therapeutic target for liver fibrosis. (PMID:30592264)
• miR-219-5p might function as a tumor suppressor in esophageal squamous cell carcinoma by directly targeting CCNA2 expression. (PMID:30766610)
• MiR-219a-5p plays a crucial role in the development of acquired drug resistance to DDP in NSCLC cells by targeting FGF9. (PMID:30999114)
• miR-219a-5p is a potentially valuable indicator of the diagnosis, prognosis of traumatic brain injury and appears to regulate neuronal apoptosis and death. (PMID:31077370)
• lncRNA MEG3 modified epithelial-mesenchymal transition of ovarian cancer cells by sponging miR-219a-5p and regulating EGFR. (PMID:31161607)
• Results found that miR-219a expression is downregulated in triple-negative breast cancer (TNBC) cells, and its overexpression could inhibit both HCP5 and BIRC3 mRNA level. (PMID:31215169)
• lncRNA CCAT1 contributes to the growth and invasion of gastric cancer via targeting miR-219-1. (PMID:31478245)
• MicroRNA-219a-5p suppresses intestinal inflammation through inhibiting Th1/Th17-mediated immune responses in inflammatory bowel disease. (PMID:31628427)
• miR-219 regulates liver cancer stem cell expansion via E-cadherin pathway. (PMID:31724462)
• Modulation of NMDA receptor by miR-219 in the amygdala and hippocampus of patients with mesial temporal lobe epilepsy. (PMID:32111564)
• Low miR219 expression is associated with proliferation and metastasis of non-small-cell lung cancer. (PMID:32159887)
• HOTAIR inhibits the proliferation of glioblastoma cells by targeting miR-219. (PMID:32176624)
• miR-219a-5p enhances the radiosensitivity of non-small cell lung cancer cells through targeting CD164. (PMID:32364222)
• MiR-219-5p inhibits prostate cancer cell growth and metastasis by targeting HMGA2. (PMID:32432734)
• MicroRNA-219 inhibits cell viability and metastasis in papillary thyroid carcinoma by targeting EYA2. (PMID:33015798)
• miR-219a-1 inhibits colon cancer cells proliferation and invasion by targeting MEMO1. (PMID:33218285)
• miR-219a suppresses human trophoblast cell invasion and proliferation by targeting vascular endothelial growth factor receptor 2 (VEGFR2). (PMID:33405003)
• MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha. (PMID:33596914)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.