MIR219A2

Summary

MIR219A2 (microRNA 219a-2, HGNC:31598) is a microRNA gene on chromosome 9q34.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 407003 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31598
Approved symbol	MIR219A2
Name	microRNA 219a-2
Location	9q34.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-219-2
Ensembl gene	ENSG00000284185
Ensembl biotype	miRNA
Entrez	407003
RNAcentral	URS000075B0B0 — miRNA, 97 nt, 30 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385220

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385220 — 1 exons

Exon	Start	End
ENSE00001500226	128392618	128392714

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 79.34.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	79.34	gold quality
skeletal muscle tissue	UBERON:0001134	78.81	gold quality
heart left ventricle	UBERON:0002084	75.25	gold quality
blood	UBERON:0000178	74.79	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.17	gold quality
vagina	UBERON:0000996	64.26	gold quality
left lobe of thyroid gland	UBERON:0001120	62.80	gold quality
esophagus mucosa	UBERON:0002469	62.46	gold quality
cerebellar hemisphere	UBERON:0002245	47.97	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 16)

• although miR-219-2 and 199b can be hemizygously lost in a significant proportion of CML cases with der(9q) deletion, they are unlikely to play a dominant role in this disease pathogenesis (PMID:18548097)
• In inflammatory exudates miR-219-2 is a key regulator of lipid mediators of inflammation and a component of the active resolution programs that may be relevant in the pathogenesis of inflammatory diseases. (PMID:22957142)
• TLX and miR-219 have an important role in both normal neurodevelopment and in schizophrenia patient iPSC-derived NSCs. TLX has a role in regulating microRNA processing, independent of its well-characterized role in transcriptional regulation. (PMID:26965827)
• Suppression of miR-219-5p may benefit the liver regeneration and prevent cirrhosis through increasing KGF. (PMID:27855391)
• study suggests that miR-219-5p may have potential applications in the diagnosis and treatment of epithelial ovarian cancer (PMID:28890378)
• Overexpression of miR-219a-5p in MDA-MB-231 cells could inhibit the expression of MRTF-A as revealed by real-time PCR and western blot analysis (PMID:29077787)
• We have been able to identify and validate absence of miR-219 detection in CSF of multiple sclerosis patients compared to controls (PMID:29202778)
• miR-219-5p could inhibit wound healing by targeting TMEM98 in keratinocytes. (PMID:30338788)
• miR-219-5p might function as a tumor suppressor in esophageal squamous cell carcinoma by directly targeting CCNA2 expression. (PMID:30766610)
• miR-219a-5p is a potentially valuable indicator of the diagnosis, prognosis of traumatic brain injury and appears to regulate neuronal apoptosis and death. (PMID:31077370)
• lncRNA MEG3 modified epithelial-mesenchymal transition of ovarian cancer cells by sponging miR-219a-5p and regulating EGFR. (PMID:31161607)
• Results found that miR-219a expression is downregulated in triple-negative breast cancer (TNBC) cells, and its overexpression could inhibit both HCP5 and BIRC3 mRNA level. (PMID:31215169)
• LBX2-AS1/miR-219a-2-3p/FUS/LBX2 positive feedback loop contributes to the proliferation of gastric cancer. (PMID:31673844)
• Modulation of NMDA receptor by miR-219 in the amygdala and hippocampus of patients with mesial temporal lobe epilepsy. (PMID:32111564)
• miR-219a-5p enhances the radiosensitivity of non-small cell lung cancer cells through targeting CD164. (PMID:32364222)
• IgGs from Human Milk Hydrolyze microRNAs. (PMID:32443717)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir219-3	ENSDARG00000102905
mus_musculus	Mir219a-2	ENSMUSG00000065485
drosophila_melanogaster	mir-219	FBGN0262376

Paralogs (1): MIR219B (ENSG00000283335)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.