MIR219B

Summary

MIR219B (microRNA 219b, HGNC:41823) is a microRNA gene on chromosome 9q34.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616335 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41823
Approved symbol	MIR219B
Name	microRNA 219b
Location	9q34.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2964a
Ensembl gene	ENSG00000283335
Ensembl biotype	miRNA
Entrez	100616335
RNAcentral	URS000075EAD8 — miRNA, 88 nt, 16 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637023

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637023 — 1 exons

Exon	Start	End
ENSE00003800381	128392621	128392708

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 72.62.

Top tissues by expression

5 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right atrium auricular region	UBERON:0006631	72.62	gold quality
heart left ventricle	UBERON:0002084	64.80	gold quality
prostate gland	UBERON:0002367	61.36	gold quality
left adrenal gland	UBERON:0001234	59.43	gold quality
thoracic mammary gland	UBERON:0005200	53.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• miR-219-5p could inhibit wound healing by targeting TMEM98 in keratinocytes. (PMID:30338788)
• Modulation of NMDA receptor by miR-219 in the amygdala and hippocampus of patients with mesial temporal lobe epilepsy. (PMID:32111564)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	Mir2964	ENSRNOG00000035452
drosophila_melanogaster	mir-219	FBGN0262376

Paralogs (1): MIR219A2 (ENSG00000284185)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.