MIR222HG

Summary

MIR222HG (miR222/221 cluster host gene, HGNC:49555) is a long non-coding RNA gene on chromosome Xp11.3.

Predicted to be part of RISC complex.

Source: NCBI Gene 104457406 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49555
Approved symbol	MIR222HG
Name	miR222/221 cluster host gene
Location	Xp11.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	Lnc-Ang362
Ensembl gene	ENSG00000270069
Ensembl biotype	lncRNA
Entrez	104457406
RNAcentral	URS000212322F — lncRNA, 24922 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 37 — 37 lncRNA

ENST00000456532, ENST00000602461, ENST00000602507, ENST00000666464, ENST00000667331, ENST00000688264, ENST00000701159, ENST00000701689, ENST00000715684, ENST00000780192, ENST00000780193, ENST00000780194, ENST00000780195, ENST00000780196, ENST00000780197, ENST00000780198, ENST00000780199, ENST00000780200, ENST00000780201, ENST00000780202, ENST00000780203, ENST00000780204, ENST00000780205, ENST00000780206, ENST00000780207, ENST00000780208, ENST00000780209, ENST00000780210, ENST00000780211, ENST00000780212, ENST00000780213, ENST00000780214, ENST00000780215, ENST00000780216, ENST00000780217, ENST00000780218, ENST00000780219

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000456532 — 3 exons

Exon	Start	End
ENSE00004027573	45849375	45849472
ENSE00004151254	45851354	45851572
ENSE00004151273	45846665	45848213

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 89.02.

FANTOM5 (CAGE): breadth broad, TPM avg 3.1324 / max 119.0440, expressed in 909 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
199035	17.5700	1446
199046	3.1324	909

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	89.02	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.69	gold quality
bone marrow cell	CL:0002092	85.82	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.37	gold quality
omental fat pad	UBERON:0010414	83.60	gold quality
vagina	UBERON:0000996	83.53	gold quality
gall bladder	UBERON:0002110	83.42	gold quality
left lobe of thyroid gland	UBERON:0001120	83.28	gold quality
left uterine tube	UBERON:0001303	83.20	gold quality
colonic epithelium	UBERON:0000397	83.08	gold quality
prostate gland	UBERON:0002367	82.60	gold quality
thyroid gland	UBERON:0002046	82.53	gold quality
cortex of kidney	UBERON:0001225	82.02	gold quality
endometrium	UBERON:0001295	81.16	gold quality
skin of abdomen	UBERON:0001416	80.95	gold quality
upper lobe of left lung	UBERON:0008952	80.68	gold quality
esophagus mucosa	UBERON:0002469	80.55	gold quality
right lobe of thyroid gland	UBERON:0001119	80.40	gold quality
body of uterus	UBERON:0009853	80.13	gold quality
ectocervix	UBERON:0012249	79.93	gold quality
stromal cell of endometrium	CL:0002255	79.86	gold quality
left ovary	UBERON:0002119	79.83	gold quality
myometrium	UBERON:0001296	79.27	gold quality
uterine cervix	UBERON:0000002	79.18	gold quality
zone of skin	UBERON:0000014	79.12	gold quality
lung	UBERON:0002048	78.79	gold quality
thoracic mammary gland	UBERON:0005200	78.63	gold quality
adipose tissue	UBERON:0001013	78.53	gold quality
ventricular zone	UBERON:0003053	78.49	gold quality
ovary	UBERON:0000992	78.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• LncRNA-Ang362 Promotes Pulmonary Arterial Hypertension by Regulating miR-221 and miR-222. (PMID:31313741)
• Lnc-Ang362 promotes cardiac fibrosis after myocardial infarction by suppressing Smad7. (PMID:32240638)
• Antagonism between splicing and microprocessor complex dictates the serum-induced processing of lnc-MIRHG for efficient cell cycle reentry. (PMID:32675111)
• Relationship between lncRNA-Ang362 and prognosis of patients with coronary heart disease after percutaneous coronary intervention. (PMID:32686826)
• MIR222HG/LIN28B/ATG5 Axis Drives M2 Macrophage Polarization and Proliferation of Hepatocellular Carcinoma Cells. (PMID:38305285)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.