MIR223HG

Summary

MIR223HG (MIR223 host gene, HGNC:54520) is a long non-coding RNA gene on chromosome Xq12.

Predicted to be part of RISC complex.

Source: NCBI Gene 115891964 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54520
Approved symbol	MIR223HG
Name	MIR223 host gene
Location	Xq12
Locus type	RNA, long non-coding
Status	Approved
Aliases	linc-223
Ensembl gene	ENSG00000274536
Ensembl biotype	lncRNA
Entrez	115891964
RNAcentral	URS00021231B4 — lncRNA, 1819 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 19 lncRNA

ENST00000618234, ENST00000621933, ENST00000658749, ENST00000689099, ENST00000691658, ENST00000795460, ENST00000795461, ENST00000795462, ENST00000795463, ENST00000795464, ENST00000795465, ENST00000795466, ENST00000795467, ENST00000795468, ENST00000795469, ENST00000795470, ENST00000795471, ENST00000795472, ENST00000795473

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000618234 — 2 exons

Exon	Start	End
ENSE00004180189	66015334	66015551
ENSE00004180209	66018824	66020422

Expression profiles

Bgee: expression breadth ubiquitous, 127 present calls, max score 96.37.

FANTOM5 (CAGE): breadth broad, TPM avg 8.5261 / max 719.7683, expressed in 397 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
196562	8.1905	393
196561	0.3356	68

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	96.37	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	96.19	gold quality
spleen	UBERON:0002106	95.50	gold quality
monocyte	CL:0000576	95.46	gold quality
leukocyte	CL:0000738	95.02	gold quality
vermiform appendix	UBERON:0001154	92.99	gold quality
bone marrow cell	CL:0002092	92.96	gold quality
bone marrow	UBERON:0002371	92.31	gold quality
granulocyte	CL:0000094	87.66	gold quality
right lung	UBERON:0002167	86.91	gold quality
upper lobe of left lung	UBERON:0008952	80.22	gold quality
lung	UBERON:0002048	77.39	gold quality
smooth muscle tissue	UBERON:0001135	77.22	gold quality
lymph node	UBERON:0000029	76.19	gold quality
small intestine Peyer’s patch	UBERON:0003454	75.80	gold quality
small intestine	UBERON:0002108	75.59	gold quality
gall bladder	UBERON:0002110	75.29	gold quality
left uterine tube	UBERON:0001303	74.87	gold quality
mucosa of transverse colon	UBERON:0004991	73.49	gold quality
duodenum	UBERON:0002114	73.33	gold quality
apex of heart	UBERON:0002098	73.22	gold quality
right adrenal gland cortex	UBERON:0035827	72.96	gold quality
right coronary artery	UBERON:0001625	72.76	gold quality
rectum	UBERON:0001052	72.59	gold quality
right adrenal gland	UBERON:0001233	72.30	gold quality
omental fat pad	UBERON:0010414	72.05	gold quality
tonsil	UBERON:0002372	71.89	gold quality
placenta	UBERON:0001987	71.70	gold quality
muscle tissue	UBERON:0002385	70.76	gold quality
adipose tissue	UBERON:0001013	70.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.71

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• [Expressing of linc-223 and miR-125a in Patients with Acute Leukemia and Its Clinical Significance]. (PMID:33283704)
• The Fusion of CLEC12A and MIR223HG Arises from a trans-Splicing Event in Normal and Transformed Human Cells. (PMID:34830054)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.