MIR2276

Summary

MIR2276 (microRNA 2276, HGNC:37313) is a microRNA gene on chromosome 13q12.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313842 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37313
Approved symbol	MIR2276
Name	microRNA 2276
Location	13q12.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2276
Ensembl gene	ENSG00000252695
Ensembl biotype	miRNA
Entrez	100313842
RNAcentral	URS000075CC5D — ncRNA, 89 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000516886

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000516886 — 1 exons

Exon	Start	End
ENSE00002089163	24162416	24162504

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 92.05.

Top tissues by expression

68 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	92.05	gold quality
blood	UBERON:0000178	81.02	gold quality
monocyte	CL:0000576	79.17	gold quality
bone marrow	UBERON:0002371	78.68	gold quality
adrenal tissue	UBERON:0018303	76.30	gold quality
stomach	UBERON:0000945	74.09	gold quality
adult mammalian kidney	UBERON:0000082	73.68	gold quality
liver	UBERON:0002107	73.34	gold quality
islet of Langerhans	UBERON:0000006	72.39	gold quality
body of stomach	UBERON:0001161	72.35	gold quality
pancreas	UBERON:0001264	72.13	gold quality
gastrocnemius	UBERON:0001388	72.05	gold quality
calcaneal tendon	UBERON:0003701	71.93	gold quality
body of pancreas	UBERON:0001150	71.68	gold quality
endometrium	UBERON:0001295	71.23	gold quality
vagina	UBERON:0000996	68.62	gold quality
left adrenal gland	UBERON:0001234	68.14	gold quality
ascending aorta	UBERON:0001496	67.81	gold quality
metanephros cortex	UBERON:0010533	67.73	gold quality
putamen	UBERON:0001874	67.63	gold quality
thoracic aorta	UBERON:0001515	67.54	gold quality
heart left ventricle	UBERON:0002084	67.41	gold quality
right atrium auricular region	UBERON:0006631	67.07	gold quality
right lobe of liver	UBERON:0001114	67.03	gold quality
body of uterus	UBERON:0009853	66.97	gold quality
myometrium	UBERON:0001296	66.28	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.21	gold quality
skin of leg	UBERON:0001511	65.71	gold quality
skin of abdomen	UBERON:0001416	65.33	gold quality
hypothalamus	UBERON:0001898	65.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.78

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.