MIR2278

Summary

MIR2278 (microRNA 2278, HGNC:37315) is a microRNA gene on chromosome 9q22.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313780 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37315
Approved symbol	MIR2278
Name	microRNA 2278
Location	9q22.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2278
Ensembl gene	ENSG00000252153
Ensembl biotype	miRNA
Entrez	100313780
RNAcentral	URS000075C899 — miRNA, 96 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000516344

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000516344 — 1 exons

Exon	Start	End
ENSE00002088621	94809962	94810057

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 92.31.

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	92.31	gold quality
kidney	UBERON:0002113	83.42	gold quality
corpus callosum	UBERON:0002336	82.86	gold quality
blood	UBERON:0000178	82.31	gold quality
liver	UBERON:0002107	81.54	gold quality
calcaneal tendon	UBERON:0003701	81.33	gold quality
adrenal tissue	UBERON:0018303	78.99	gold quality
adult mammalian kidney	UBERON:0000082	78.80	gold quality
stomach	UBERON:0000945	77.78	gold quality
lung	UBERON:0002048	76.45	gold quality
anterior cingulate cortex	UBERON:0009835	73.28	gold quality
endometrium	UBERON:0001295	71.88	gold quality
body of pancreas	UBERON:0001150	71.81	gold quality
monocyte	CL:0000576	71.59	gold quality
heart left ventricle	UBERON:0002084	70.90	gold quality
gastrocnemius	UBERON:0001388	70.77	gold quality
heart	UBERON:0000948	70.55	gold quality
adrenal gland	UBERON:0002369	70.14	gold quality
substantia nigra	UBERON:0002038	69.93	gold quality
body of stomach	UBERON:0001161	69.78	gold quality
intestine	UBERON:0000160	69.60	gold quality
colon	UBERON:0001155	69.58	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.44	gold quality
right lobe of liver	UBERON:0001114	67.69	gold quality
tibial artery	UBERON:0007610	67.67	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.66	gold quality
ascending aorta	UBERON:0001496	67.29	gold quality
thoracic aorta	UBERON:0001515	67.26	gold quality
left adrenal gland	UBERON:0001234	67.20	gold quality
vagina	UBERON:0000996	67.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Loss of hsa-miR-2278 is associated with chronic myeloid leukemia. (PMID:25953263)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.