MIR2355

Summary

MIR2355 (microRNA 2355, HGNC:38328) is a microRNA gene on chromosome 2q33.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423036 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38328
Approved symbol	MIR2355
Name	microRNA 2355
Location	2q33.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2355
Ensembl gene	ENSG00000253008
Ensembl biotype	miRNA
Entrez	100423036
RNAcentral	URS000075D52C — miRNA, 87 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000517199

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000517199 — 1 exons

Exon	Start	End
ENSE00002089476	207109987	207110073

Expression profiles

Bgee: expression breadth broad, 84 present calls, max score 85.89.

Top tissues by expression

84 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	85.89	gold quality
kidney	UBERON:0002113	84.23	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.50	gold quality
blood	UBERON:0000178	80.80	gold quality
calcaneal tendon	UBERON:0003701	80.52	gold quality
adrenal tissue	UBERON:0018303	80.05	gold quality
monocyte	CL:0000576	77.67	gold quality
bone marrow	UBERON:0002371	77.03	gold quality
liver	UBERON:0002107	76.40	gold quality
endometrium	UBERON:0001295	75.11	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	74.93	gold quality
stomach	UBERON:0000945	74.46	gold quality
corpus callosum	UBERON:0002336	74.40	gold quality
gastrocnemius	UBERON:0001388	72.74	gold quality
heart left ventricle	UBERON:0002084	71.84	gold quality
islet of Langerhans	UBERON:0000006	71.75	gold quality
heart	UBERON:0000948	71.70	gold quality
adrenal gland	UBERON:0002369	71.38	gold quality
body of pancreas	UBERON:0001150	68.94	gold quality
right atrium auricular region	UBERON:0006631	68.89	gold quality
intestine	UBERON:0000160	68.85	gold quality
left coronary artery	UBERON:0001626	68.69	gold quality
transverse colon	UBERON:0001157	68.23	gold quality
tonsil	UBERON:0002372	68.23	gold quality
colon	UBERON:0001155	68.16	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.11	gold quality
body of stomach	UBERON:0001161	68.09	gold quality
ascending aorta	UBERON:0001496	67.99	gold quality
left adrenal gland	UBERON:0001234	67.97	gold quality
lower esophagus	UBERON:0013473	67.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• MiR-2355-5p negatively regulated ERFFI1 and prevented the effects of ERRFI1 on inhibiting NP cells proliferation and inflammation. (PMID:30817728)
• LncRNA DDX11-AS1 Promotes Bladder Cancer Occurrence Via Protecting LAMB3 from Downregulation by Sponging miR-2355-5p. (PMID:32412777)
• LncRNA WDFY3-AS2 suppresses proliferation and invasion in oesophageal squamous cell carcinoma by regulating miR-2355-5p/SOCS2 axis. (PMID:32536038)
• MicroRNA-2355-5p regulates gamma-globin expression in human erythroid cells by inhibiting KLF6. (PMID:33368182)
• Deciphering the effects of PYCR1 on cell function and its associated mechanism in hepatocellular carcinoma. (PMID:34239351)
• Diagnostic and prognostic value of microRNA-2355-3p and contribution to the progression in lung adenocarcinoma. (PMID:34334103)
• CircRNA SOD2 motivates non-small cell lungs cancer advancement with EMT via acting as microRNA-2355-5p’s competing endogenous RNA to mediate calmodulin regulated spectrin associated proteins-2. (PMID:35188072)
• Chitosan-Gelatin-EGCG Nanoparticle-Meditated LncRNA TMEM44-AS1 Silencing to Activate the P53 Signaling Pathway for the Synergistic Reversal of 5-FU Resistance in Gastric Cancer. (PMID:35717675)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.