MIR2392

Summary

MIR2392 (microRNA 2392, HGNC:41843) is a microRNA gene on chromosome 14q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616495 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41843
Approved symbol	MIR2392
Name	microRNA 2392
Location	14q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-2392
Ensembl gene	ENSG00000266461
Ensembl biotype	miRNA
Entrez	100616495
RNAcentral	URS0000759E16 — miRNA, 84 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584881

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584881 — 1 exons

Exon	Start	End
ENSE00002719980	100814491	100814574

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 73.61.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	73.61	gold quality
blood	UBERON:0000178	72.11	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.07	gold quality
skin of abdomen	UBERON:0001416	66.87	gold quality
intestine	UBERON:0000160	65.89	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.19	gold quality
colon	UBERON:0001155	64.04	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.74	gold quality
left testis	UBERON:0004533	45.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• These findings indicate that the miR-2392-MAML3/WHSC1-Slug/Twist1 regulatory axis plays a critical role in GC metastasis. (PMID:28512191)
• CACNA1G-AS1 promotes hepatocellular carcinoma progression through regulating the miR-2392/C1orf61 pathway. (PMID:30908634)
• BTXA regulates the epithelial-mesenchymal transition and autophagy of keloid fibroblasts via modulating miR-1587/miR-2392 targeted ZEB2. (PMID:31652445)
• Role of miR-2392 in driving SARS-CoV-2 infection. (PMID:34624208)
• miR-2392 functions as tumour suppressor and inhibits malignant progression of hepatocellular carcinoma via directly targeting JAG2. (PMID:35485355)
• Positive effect of miR-2392 on fibroblast to cardiomyocyte-like cell fate transition: An in silico and in vitro study. (PMID:37393060)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.