MIR23AHG

Summary

MIR23AHG (miR-23a/27a/24-2 cluster host gene, HGNC:27620) is a long non-coding RNA gene on chromosome 19p13.12.

Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex.

Source: NCBI Gene 284454 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27620
Approved symbol	MIR23AHG
Name	miR-23a/27a/24-2 cluster host gene
Location	19p13.12
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC284454, Smyca
Ensembl gene	ENSG00000267519
Ensembl biotype	lncRNA
Entrez	284454
RNAcentral	URS0000D77F8F — lncRNA, 8403 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000587762, ENST00000789019

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000587762 — 1 exons

Exon	Start	End
ENSE00002961917	13823880	13842928

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 91.07.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 28.5946 / max 3450.9559, expressed in 1739 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
179556	28.3888	1735
179529	0.2059	64

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	91.07	gold quality
bone marrow	UBERON:0002371	85.21	gold quality
mucosa of stomach	UBERON:0001199	79.27	gold quality
blood	UBERON:0000178	78.66	gold quality
monocyte	CL:0000576	77.38	gold quality
leukocyte	CL:0000738	76.72	gold quality
ascending aorta	UBERON:0001496	75.77	gold quality
thoracic aorta	UBERON:0001515	75.30	gold quality
granulocyte	CL:0000094	74.33	gold quality
right coronary artery	UBERON:0001625	73.90	gold quality
hindlimb stylopod muscle	UBERON:0004252	73.79	gold quality
colonic epithelium	UBERON:0000397	73.57	gold quality
skin of abdomen	UBERON:0001416	73.29	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	73.05	gold quality
left uterine tube	UBERON:0001303	72.95	gold quality
zone of skin	UBERON:0000014	71.84	gold quality
sural nerve	UBERON:0015488	71.58	gold quality
left coronary artery	UBERON:0001626	71.56	gold quality
descending thoracic aorta	UBERON:0002345	71.41	gold quality
upper lobe of left lung	UBERON:0008952	71.05	gold quality
popliteal artery	UBERON:0002250	70.60	gold quality
tibial artery	UBERON:0007610	70.60	gold quality
skin of leg	UBERON:0001511	70.56	gold quality
apex of heart	UBERON:0002098	70.47	gold quality
gastrocnemius	UBERON:0001388	70.29	gold quality
gall bladder	UBERON:0002110	70.19	gold quality
skeletal muscle tissue	UBERON:0001134	69.98	gold quality
muscle tissue	UBERON:0002385	69.89	gold quality
muscle of leg	UBERON:0001383	69.76	gold quality
stromal cell of endometrium	CL:0002255	69.61	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-10287	no	787.67
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• RIP-seq analysis in HEK293T cells identifies a complete repertoire of DDX5/p68 interacting transcripts including LOC284454 lncRNA. The RNA is located in the same primary transcript harboring miR-23a approximately 27a approximately 24-2 cluster and expressed in multiple human tissues. Its expression is significantly reduced in many cancers. Loss and gain of function study reveales perturbation of genes related to cancer… (PMID:29227193)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.