MIR23C

Summary

MIR23C (microRNA 23c, HGNC:38913) is a microRNA gene on chromosome Xp22.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100500809 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38913
Approved symbol	MIR23C
Name	microRNA 23c
Location	Xp22.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-23c
Ensembl gene	ENSG00000264566
Ensembl biotype	miRNA
Entrez	100500809
RNAcentral	URS000075BD51 — miRNA, 100 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579846

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579846 — 1 exons

Exon	Start	End
ENSE00002727393	20017088	20017187

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 91.11.

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	91.11	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.88	gold quality
body of stomach	UBERON:0001161	82.69	gold quality
stomach	UBERON:0000945	82.07	gold quality
right hemisphere of cerebellum	UBERON:0014890	81.18	gold quality
cerebellar hemisphere	UBERON:0002245	79.39	gold quality
placenta	UBERON:0001987	77.71	gold quality
fundus of stomach	UBERON:0001160	77.55	gold quality
monocyte	CL:0000576	77.10	gold quality
metanephros cortex	UBERON:0010533	76.94	gold quality
muscle of leg	UBERON:0001383	76.29	gold quality
blood	UBERON:0000178	75.60	gold quality
islet of Langerhans	UBERON:0000006	75.14	gold quality
gastrocnemius	UBERON:0001388	74.64	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.55	gold quality
body of pancreas	UBERON:0001150	73.54	gold quality
endometrium	UBERON:0001295	73.21	gold quality
nucleus accumbens	UBERON:0001882	73.08	gold quality
brain	UBERON:0000955	72.62	gold quality
right adrenal gland cortex	UBERON:0035827	72.50	gold quality
right frontal lobe	UBERON:0002810	72.43	gold quality
frontal cortex	UBERON:0001870	72.37	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.03	gold quality
cerebral cortex	UBERON:0000956	71.41	gold quality
right uterine tube	UBERON:0001302	71.33	gold quality
heart left ventricle	UBERON:0002084	71.14	gold quality
myometrium	UBERON:0001296	71.07	gold quality
right adrenal gland	UBERON:0001233	71.03	gold quality
anterior cingulate cortex	UBERON:0009835	71.03	gold quality
hypothalamus	UBERON:0001898	70.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• miR-23c inhibited cell proliferation and accelerated apoptosis by attenuating ERBB2IP. (PMID:30103114)
• Erbb2 interacting protein (ERBB2IP), a known target of miR-23c, was positively regulated by KTN1-AS1. (PMID:30551364)
• miR-23c regulates wound healing by targeting stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12) among patients with infected diabetic foot ulcers. (PMID:31520606)
• Regucalcin promotes dormancy of prostate cancer. (PMID:33323968)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.