MIR24-1

Summary

MIR24-1 (microRNA 24-1, HGNC:31607) is a microRNA gene on chromosome 9q22.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 407012 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31607
Approved symbol	MIR24-1
Name	microRNA 24-1
Location	9q22.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-24-1
Ensembl gene	ENSG00000284459
Ensembl biotype	miRNA
OMIM	609705
Entrez	407012
RNAcentral	URS00003A9237 — miRNA, 68 nt, 26 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637495

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637495 — 1 exons

Exon	Start	End
ENSE00003793805	95086021	95086088

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 88.92.

Top tissues by expression

36 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	88.92	gold quality
liver	UBERON:0002107	80.78	gold quality
urinary bladder	UBERON:0001255	73.91	gold quality
blood	UBERON:0000178	72.72	gold quality
muscle of leg	UBERON:0001383	71.10	gold quality
stomach	UBERON:0000945	70.54	gold quality
gastrocnemius	UBERON:0001388	70.15	gold quality
body of stomach	UBERON:0001161	66.72	gold quality
anterior cingulate cortex	UBERON:0009835	63.86	gold quality
hypothalamus	UBERON:0001898	62.22	gold quality
amygdala	UBERON:0001876	61.96	gold quality
skin of leg	UBERON:0001511	61.92	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	61.56	gold quality
right atrium auricular region	UBERON:0006631	61.12	gold quality
right hemisphere of cerebellum	UBERON:0014890	60.78	gold quality
omental fat pad	UBERON:0010414	59.89	gold quality
right frontal lobe	UBERON:0002810	59.15	gold quality
nucleus accumbens	UBERON:0001882	57.66	gold quality
brain	UBERON:0000955	57.51	gold quality
caudate nucleus	UBERON:0001873	57.01	gold quality
Ammon’s horn	UBERON:0001954	56.96	gold quality
Brodmann (1909) area 9	UBERON:0013540	56.12	gold quality
tibial nerve	UBERON:0001323	55.87	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	55.69	gold quality
subcutaneous adipose tissue	UBERON:0002190	55.62	gold quality
upper lobe of left lung	UBERON:0008952	55.62	gold quality
putamen	UBERON:0001874	55.57	gold quality
left lobe of thyroid gland	UBERON:0001120	54.97	gold quality
skin of abdomen	UBERON:0001416	53.83	gold quality
fallopian tube	UBERON:0003889	53.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• miR-24 upregulation in postreplicative cells reduces H2AX and makes them vulnerable to DNA damage. (PMID:19377482)
• A molecular basis for the antagonism between the PDGF and TGFbeta pathways, and its effect on the control of the vascular smooth muscle cells phenotype. (PMID:20019669)
• miR-24, a ubiquitously expressed miRNA, has an anti-proliferative effect independent of p53 function. (PMID:20041160)
• Data show that miR-24 regulates apoptosis by targeting FAF1 in cancer cells. (PMID:20195546)
• MiR-24 up-regulation reduced the expression of RNA-binding protein dead end 1 (DND1). Knockdown of miR-24 led to enhanced expression of DND1. (PMID:20816961)
• Results identify a novel regulatory paradigm wherein L11 plays a critical role in controlling c-myc mRNA turnover via recruiting miR-24/miRISC in response to ribosomal stress. (PMID:21807902)
• MEN1 tumorigenesis seems to be under the control of a “negative feedback loop” between miR-24-1 and menin protein, that mimics the second hit of Knudson’s hypothesis (PMID:22761894)
• downregulation of miR-24 in prostate cancer corresponds to an upregulation of ZNF217 (PMID:22815235)
• miR-24 is a direct regulator of ST7L. (PMID:23142218)
• We validate miR-24 as a suitable reference microRNA for diffuse large B-cell lymphoma formalin-fixed paraffin-embedded tissue studies. (PMID:23172553)
• We showed that miR-24 and miR-27a were significantly downregulated in HCCs from cirrhotic liver tissues in comparison to those from non-cirrhotic liver tissues. (PMID:23229173)
• These findings reveal, for the first time, the novel functions of cooperation of miR243p and miR27a3p from two clusters in promoting cell proliferation through MXI1. (PMID:23254855)
• these results suggest that miR-24 plays a key role in breast cancer invasion and metastasis. miR-24 could potentially be a target for cancer intervention. (PMID:23418360)
• findings functionally link the miR-24/MODY gene regulatory pathway to the onset of type 2 diabetes and create a novel network between nutrient overload and genetic diabetes via miR-24. (PMID:23761103)
• these data support the involvement of miR-22, miR-24, and miR-34a in advanced non-small cell lung cancer (PMID:23794259)
• Normal adrenal tissue and aldosterone-producing adenoma differ significantly and reproducibly in their miRNA expression profiles, with miR-24 significantly downregulated in the latter. (PMID:23836801)
• expression of miR-24-3p mediates plasma cell survival (PMID:23934711)
• Human mir-24 is an inhibitor of smooth muscle cell proliferation, contributing to loss of vascularization. (PMID:24063572)
• HPV16 E6 and E7 proteins affected expression of miR-24 and miR-205 during proliferation and differentiation of keratinocytes. (PMID:24314651)
• We disclosed herein a new role of the senescence marker p16INK4a and its regulation by miR-24 during osteoarthritis and terminal chondrogenesis. (PMID:24572376)
• Our findings show a novel mechanism by which miR-24 promotes hepatic lipid accumulation and hyperlipidemia by repressing Insig1. (PMID:24677249)
• Downregulation of microRNA-24 and microRNA-181 parallels the upregulation of IFN-gamma secreted by activated human CD4 lymphocytes. (PMID:24704866)
• These results indicate for the first time that miR-24 may modify AFB1-related HCC prognosis and tumorigenesis. (PMID:24800232)
• miR-24 promotes renal ischemic injury by stimulating apoptosis in endothelial and tubular epithelial cells (PMID:24854275)
• miR-24 functions as a novel tumor suppressor in gastric cancer, and the anti-oncogenic activity may involve its inhibition of the target gene REG4. (PMID:24886316)
• findings support a lung metastasis-promoting function of the miR-23b/27b/24 cluster of miRNAs, which functions in part through the direct inhibition of PSAP in breast cancer (PMID:24966325)
• MicroRNA-24 expression in human atherosclerotic plaques was inversely related to MMP-14 protein expression. Stable plaques had more microRNA-24than unstable plaques. It colocalized with foam cell macrophages with low MMP-14 protein expression. (PMID:24990232)
• miR-24-1-FOXM1 axis contributes to cancer cell proliferation in bladder cancer (PMID:24999187)
• High miR-24 expression is associated with hepatocellular carcinoma. (PMID:25073511)
• downregulation of the miR-23b/27b/24-1 cluster was a frequent event in prostate cancer, and these clustered miRNAs functioned as tumor suppressors (PMID:25115396)
• Over-expression of miR-24 and miR-378 in formalin-fixed paraffin-embedded tissue of breast cancer patients might conduct as an ideal source for biomarker discovery and validation in breast cancer patients. (PMID:25120807)
• Nucleotidyl transferase TUT1 inhibits lipogenesis in osteosarcoma cells through regulation of microRNA-24 and microRNA-29a. (PMID:25142229)
• Our findings defined a central role for miR24 as a tumor-suppressive miRNA in NPC and suggested its use in novel strategies for treatment of this cancer. (PMID:25319395)
• conclude that miR-24-3p regulates autophagy by targeting ATG4A (PMID:25426560)
• Down-regulation of miR-24-3p contributes to the development and progression of colorectal cancer (PMID:25502080)
• These findings implicated that miR-24 high regulation is a common event in acute myeloid leukemia with t(8;21). (PMID:25550847)
• these results demonstrate that miR-24, miR-30b, and miR-142-3p regulate phagocytosis and associated cytokine production in myeloid inflammatory cells through modulation of various genes involved in the pathway. (PMID:25601927)
• MiR-24 acted as an oncomir, at least partially through regulation of its functional target NAIF1 in non-small cell lung cancer. (PMID:25725584)
• miR-24 represents a novel therapeutic target to prevent adverse thrombotic events in patients with diabetes mellitus. (PMID:25814526)
• We also demonstrated that miR-24 suppressed the expression of chitinase 3-like 1 (CHI3L1) mRNA, thought to mediate multiple signaling pathways (PMID:25976273)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	dre-mir-24-4	ENSDARG00000081769
mus_musculus	Mir24-1	ENSMUSG00000105904

Paralogs (2): MIR3074 (ENSG00000207617), MIR24-2 (ENSG00000284387)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.